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TSRI Faculty Interests
High-Throughput Screening Balch, William E.
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Dickerson, Tobin
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Finn, M.G.
uses viruses as building blocks for biologically active structures, diagnostic agents, immunogenic platforms, and drug delivery vehicles; and also develops new bioconjugation methods, enzyme inhibitors, and functional materials using "click chemistry," and studies organic and organometallic reaction mechanisms.
Fokin, Valery
develops preactical catalytic transformations for organic synthesis, combinatorial chemistry, chemical biology, and materials research; searches for novel antiviral agents, nicotinic receptor ligands, and protease inhibitors.
Gerace, Larry
seeks to understand the mechanisms for regulation of signaling and cell differentiation by components of the nuclear envelope, particularly in regard to muscle, and the machinery for posttranscriptional regulation of gene expression by nucleocytoplasmic transport, mRNA translation and protein turnover, with focus on HIV-1.
Ghadiri, M.Reza
develops novel methods for the rational design and construction of functional and interesting bioorganic molecules, such as novel antimicrobial agents, catalytic peptides, biosensors, self-replicating systems, and molecular logic gates.
Janda, Kim
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Jegla, Timothy
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Joyce, Gerald
studies the test-tube evolution of RNA and DNA enzymes, both to explore their potential biomedical applications and to examine their possible role in the early history of life on Earth.
Kelly, Jeffery
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Nemerow, Glen
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Oldstone, Michael
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Patapoutian, Ardem
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Romesberg, Floyd
seeks to understand and evolve novel protein function by expanding the genetic code, to understand the molecular basis of DNA damage, repair, and mutagenesis, and to use femtosecond laser pulses to probe protein dynamics.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Wilson, Ian
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.
Winzeler, Elizabeth
develops new genome analysis technologies and applies them to study agents of infectious disease, such as the malaria parasite Plasmodium falciparum; her goal is to use genome sequence information, microarrays, and proteomics as a substitute for traditional forward and reverse genetic approaches for elucidation of gene function.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Yu, Jin-Quan
Discovers regioselective and enantioselective reactions based on C-H activations and applies these reactions to drug discovery and natural product synthesis.
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