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TSRI Faculty Interests
Heart Disease Buxbaum, Joel
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Getzoff, Elizabeth
aims to characterize functionally important protein conformational states by coupling crystallography, spectroscopy, molecular biology and computational analyses, and to apply that knowledge to protein and inhibitor design for key biological processes, including photoactivity, electron transfer, and enzyme catalysis.
MacRae, Ian
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Milligan, Ronald
uses cryo-electron microscopy and image analysis to study the structure and mechanism of action of large molecular machines such as actomyosin, kinesin-microtubules, MAPs-microtubles, VCP/p97 and dynein AAA ATPases, various membrane channels and transporters, and bacterial toxins.
Noodleman, Louis
uses quantum chemistry and protein electrostatics to investigate the electronic structures and active site mechanisms of redox metalloproteins, such as respiratory iron-sulfur proteins, the nitrogen fixing nitrogenase enzyme, and the iron-oxo dimer enzymes methane monooxygenase and ribonucleotide reductase.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Salomon, Daniel
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Schmid, Sandra
is defining the molecular mechanisms of receptor-mediated endocytosis, which involves the concentration of receptor-ligand complexes into clathrin coated pits, their internalization via coated vesicles, and the regulation of these events by GTPases and kinases.
Schork, Nicholas
focuses on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design, integration, and interpretation of studies making use of contemporary high throughput genomic technologies.
Topol, Eric
studies the genome of patients who have particular medical conditions or who have been healthy beyond the 8th decade to determine variants associated with the phenotype. His research moves this information forward in medicine to provide individualization of medical care in the future.
Wiseman, R. Luke
is interested in understanding the cellular and energetic factors that dictate intracellular protein folding as it relates to human disease.
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