TSRI Faculty Interests

Diabetes

Ding, Sheng  
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.

Feeney, Ann  
studies the epigenetic and genetic mechanisms that control the accessibility of antibody V, D, and J genes to undergo V(D)J recombination, determining why individual V genes rearrange with very different frequencies, and determining how the generation of the antibody repertoire and B cell tolerance mechanisms are misregulated in murine models of autoimmune disease

Friedlander, Martin  
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.

Jameson, Julie  
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.

Kralli, Anastasia  
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.

Saez, Enrique  
is interested in two broad themes related to the regulation of energy balance in mammals.

Salomon, Daniel  
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.

Sauer, Karsten  
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.

Schmid, Sandra  
is defining the molecular mechanisms of receptor-mediated endocytosis, which involves the concentration of receptor-ligand complexes into clathrin coated pits, their internalization via coated vesicles, and the regulation of these events by GTPases and kinases.

Sherman, Linda  
looks at the immune system's basic strategy of discriminating between "self" and "non-self" through T lymphocytes, seeking to augment their ability to respond to certain self-antigens on tumor cells and to diminish their aberrant destruction of self-tissue in autoimmune diseases.

Surh, Charles  
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.