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TSRI Faculty Interests
Alzheimer\'s Disease Balch, William E.
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Baldwin, Kristin
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Baran, Phil
explores new avenues for the efficient and practical construction of organic molecules, both naturally occurring and man-made, by pursuing longstanding synthetic challenges and by designing methods of broad utility.
Buxbaum, Joel
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
Chun, Jerold
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Dyson, Helen Jane
uses NMR to study the protein-folding process and to study the nature and behavior of unfolded and partly folded forms of proteins, including prion proteins and several newly-discovered, intrinsically unstructured proteins.
Janda, Kim
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Kelly, Jeffery
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
MacRae, Ian
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Nicolaou, K.C.
works on the total synthesis of biologically active natural and designed molecules and the discovery and development of new synthetic strategies and technologies.
Powers, Evan
is interested in the energetics and mechanisms of protein folding and aggregation.
Reed, Steven
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Wiseman, R. Luke
is interested in understanding the cellular and energetic factors that dictate intracellular protein folding as it relates to human disease.
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