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TSRI Faculty Interests
Signal Transduction Boger, Dale
works on the total synthesis of biologically active natural products using the tools of organic synthesis to identify, imitate, understand, exploit, and sometimes surpass what nature provides.
Bokoch, Gary
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Chun, Jerold
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Crossin, Kathryn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Deniz, Ashok
develops and uses single-molecule fluorescence methods to study the dynamics and interactions of biological molecules during such processes as protein/RNA folding and assembly of the 30S subunit of the bacterial ribosome.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gascoigne, Nicholas
examines molecular and genetic interactions in T cell development and activation, including the spatiotemporal analysis of signaling cascades using fluorescence resonance energy transfer (FRET) and other techniques to image molecular interactions in live cells.
Gruol, Donna
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Jameson, Julie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Mc Gowan, Clare
examines the molecular mechanisms and players that regulate the human cell cycle, focusing on DNA damage checkpoints and DNA repair enzymes like Mus81, which resolves strands of duplex DNA that become crossed during replication.
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Mowen, Kerri
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Otomo, Takanori
studies structure and function of proteins involved in the autophagic pathway.
Reed, Steven
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Russell, Paul
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
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