TSRI Faculty Interests

Proteomics

Balch, William E. 
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.

Cline, Hollis  
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.

Cravatt, Benjamin  
studies the action and regulation of chemical messengers, particularly the fatty acid amides, which mediate physiological phenomena like pain sensation, sleep, and thermoregulation; he designs and uses chemical probes for "active site proteomics," the global analysis of protein function.

Dickerson, Tobin  
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.

Quigley, James  
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.

Reed, Steven  
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.

Russell, Paul  
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.

Stevens, Raymond  
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.

Wilson, Ian  
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.

Wittenberg, Curt  
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.

Wong, Chi-Huey  
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.

Wuthrich, Kurt  
develops advanced techniques in nuclear magnetic resonance (NMR) spectroscopy and applies them in protein structural biology and structural genomics projects.

Xiao, Changchun  
studies the functions of microRNA control and its underlying molecular mechanisms in the mammalian immune system, under health and disease conditions.