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TSRI Faculty Interests
Cell Biology Asturias, Francisco
studies the structures of macromolecular assemblies involved in eukaryotic gene expression and its control, such as complexes formed by RNA polymerase II and general transcription factors, using the technique of cryoelectron microscopy.
Balch, William E.
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Baldwin, Kristin
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Bokoch, Gary
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Chun, Jerold
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Cline, Hollis
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.
Crossin, Kathryn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Cunningham, Bruce
studies the detailed properties of cell surface glycoproteins that play critical roles in neural development, particularly cell adhesion molecules (CAMs), which bind cells together and generate signals that determine a cell's developmental destiny.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Edelman, Gerald
examines several areas related to nervous system development and neural function, including cell-cell interactions during embyronic development, the role of cell adhesion molecules in neural plasticity, the molecular genetics of connectional defects in the nervous system, and transcriptional regulation and translational control in eukaryotic cells.
Felding-Habermann, Brunhilde
establishes unique models of brain metastasis from circulating tumor cells of breast cancer patients and analyzes their properties in vitro and in vivo, investigates genes and functional pathways that control metastatic activity.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gerace, Larry
seeks to understand the mechanisms for regulation of signaling and cell differentiation by components of the nuclear envelope, particularly in regard to muscle, and the machinery for posttranscriptional regulation of gene expression by nucleocytoplasmic transport, mRNA translation and protein turnover, with focus on HIV-1.
Jameson, Julie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Mc Gowan, Clare
examines the molecular mechanisms and players that regulate the human cell cycle, focusing on DNA damage checkpoints and DNA repair enzymes like Mus81, which resolves strands of duplex DNA that become crossed during replication.
Milligan, Ronald
uses cryo-electron microscopy and image analysis to study the structure and mechanism of action of large molecular machines such as actomyosin, kinesin-microtubules, MAPs-microtubles, VCP/p97 and dynein AAA ATPases, various membrane channels and transporters, and bacterial toxins.
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Nemerow, Glen
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Otomo, Takanori
studies structure and function of proteins involved in the autophagic pathway.
Paulson, James
studies carbohydrate recognition and the molecular biology of carbohydrate binding proteins, like CD22, which mediate key aspects of cell signaling in the immune system.
Quigley, James
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Reed, Steven
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Russell, Paul
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Schmid, Sandra
is defining the molecular mechanisms of receptor-mediated endocytosis, which involves the concentration of receptor-ligand complexes into clathrin coated pits, their internalization via coated vesicles, and the regulation of these events by GTPases and kinases.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Wiseman, R. Luke
is interested in understanding the cellular and energetic factors that dictate intracellular protein folding as it relates to human disease.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
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