TSRI Faculty Interests

Bioinformatics

Balch, William E. 
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.

Beutler, Bruce  
searches for genes that are required for normal immune function through germline mutagenesis and positional cloning.

Mc Gowan, Clare  
examines the molecular mechanisms and players that regulate the human cell cycle, focusing on DNA damage checkpoints and DNA repair enzymes like Mus81, which resolves strands of duplex DNA that become crossed during replication.

Patapoutian, Ardem  
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.

Salomon, Daniel  
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.

Schork, Nicholas  
focuses on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design, integration, and interpretation of studies making use of contemporary high throughput genomic technologies.

Winzeler, Elizabeth  
develops new genome analysis technologies and applies them to study agents of infectious disease, such as the malaria parasite Plasmodium falciparum; her goal is to use genome sequence information, microarrays, and proteomics as a substitute for traditional forward and reverse genetic approaches for elucidation of gene function.