TSRI Faculty Interests

Vascular Biology

Felding-Habermann, Brunhilde  
establishes unique models of brain metastasis from circulating tumor cells of breast cancer patients and analyzes their properties in vitro and in vivo, investigates genes and functional pathways that control metastatic activity.

Fowler, Velia  
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.

Friedlander, Martin  
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.

Milner, Richard  
uses a combination of mouse models and tissue culture cell–based assays to examine the role of fibronectin and endothelial fibronectin receptors in promoting cerebral angiogenesis during cerebral hypoxia and ischemia.

Quigley, James  
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.

Salomon, Daniel  
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.