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Faculty
Kim Janda
Ely R. Callaway, Jr. Professor of Chemistry
Professor Director, Worm Institute of Research & Medicine (WIRM)
Department of Chemistry
TSRI - 1985
Joint Appointments Immunology
Education
B.S., University of South Florida, 1980
M.S., University of Arizona, 1983
Ph.D., University of Arizona, 1984
Awards & Activities
Arthur C. Cope Scholar Award 1999; NIH First Award 1990-1995
Alfred P. Sloan Fellowship 1993-1995
University of South Florida Outstanding Alumnus in Chemistry 2001
J. Clarence Karcher Lecturer, University of Oklahoma, Norman, Oklahoma
Alumni of the Year, University of South Florida, Tampa, Florida
Editorial Boards: Chemical Reviews, Combinatorial Chemistry Research and Applications, Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Combinatorial Chemistry High-Throughput Screening.
Scientific Advisory Boards: Acidophil LLC, Aventis Pharmaceuticals, Chembiotek Research International, Dihedron LLC, Materia Inc., Joint Scientific Council Committee, Novartis/TSRI.
Steering committees: Novartis/TSRI.
Research Focus
Merging of Chemistry and Biology
Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, investigation and development of molecules that block quorum sensing in bacteria, cell-penetrating peptides as therapeutics, protein-polymer neural tissue regeneration, and protein glycation with metabolized drugs of abuse.
Selected References
Zorilla, E.P., Iwasaki, S., Moss, J.A., Chang, J., Otsuji, J., Inoue, K., Meijler, M.M., Janda, K.D. Vaccination against weight gain, Proc. Natl. Acad. Sci. USA 103:13226, 2006.
Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D. Unexpected acetylcholinesterase activity of cocaine esterases, J. Am. Chem. Soc. 128:15364, 2006.
Eubanks, L.M., Rogers, C.J., Beuscher IV, A.E., Koob, G.F., Olson, A.J., Dickerson, T.J., Janda, K.D. A molecular link between the active component of marijuana and Alzheimer's disease pathology, Mol. Pharmaceutics 3:773, 2006.
McAllister, L.A., Hixon, M.S., Kennedy, J.P., Dickerson, T.J., Janda, K.D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin, J. Am. Chem. Soc. 128:4176, 2006.
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