Faculty

Julie Jameson 
Assistant Professor
Immunology and Microbial Science
TSRI - 1999

Education 
1994 B.A., Biology, University of California, Santa Barbara
1999, Ph.D., Immunology and Virology, University of Massachusetts Medical Center, Worcester, Massachusetts
1999-2004, Research Associate with Dr. Wendy Havran, The Scripps Research Institute, La Jolla, California
2004-2005, Senior Research Associate, The Scripps Research Institute, La Jolla, California

Awards & Activities 
12th International Congress of Immunology, ICI/IUIS, travel award (2004)
Organizing committee and session chair, International γδ T Cell Conference (2006)
Leukemia and Lymphoma Society, Special Fellow (2003-2006)
San Diego Cutaneous Biologists (2006-present)

Research Focus 
Function of γδ T Cells in Murine Models of Disease
Work is underway in our laboratory to examine the mechanisms that result in skin γδ T cells dysfunction in non-healing wounds. We have previously shown that skin γδ T cell-derived growth factors play roles in skin homeostasis and wound repair. Now we are initiating studies to determine whether skin γδ T cells are dysregulated in non-healing wounds of diabetic mice. Cross-talk between key growth factors produced by skin γδ T cells and their receptors expressed on keratinocytes are being examined. In other studies we are investigating the function of skin γδ T cells during rapamycin treatment. Rapamycin (sirolimus, Rapamune) is approved by the U.S. Food and Drug Administration for prophylaxis of acute rejection. However patients that receive rapamycin report an increased incidence of wound healing complications. We are currently examining mechanisms that may contribute to this skin γδ T cell dysfunction. Once we fully understand the role of T cells in tissue repair, it may be possible to design therapies that enhance the ability of these immune cells to heal diabetic ulcers and other chronic wounds.

Selected References 
Terajima, M., Cruz, J., Leporati, A.M., Orphin, L., Babon, J.A., Co, M.D., Pazoles, P., Jameson, J., and Ennis, F.A. (2008). Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. J. Virol. 82:9283.

Mills, R.E., Taylor, K.R., Podshivalova, K., McKay, D.E., and Jameson, J.M. (2008). Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice. J. Immunol. 181:3974.

Mills, R.E. and Jameson, J.M. (2009). T cell dependence on mTOR signaling. Cell Cycle. 15:545.

Toulon, A., Breton, L., Tenenhaus, M., Bhavsar, D., Lanigan, C., Rudolph, R., Jameson, J., and Havran, W. (2009). A role for human skin resident T cells in wound healing. J. Exp. Med. 206:743-750.