Faculty

Steven Reed 
Professor
Department of Molecular Biology
TSRI - 1986

Education 
B.S., Yale University, 1970

Ph.D., Stanford University, 1976

Awards & Activities 
Associate Editor, Journal of Molecular Biology; Editorial Board, Molecular and Cellular Biology, Molecular Biology of the Cell, Cell Cycle.

Research Focus 
Molecular Mechanisms of Cell Cycle Control
in Yeast and Animal Cells.

Research in our laboratory focuses on the molecular basis for regulation of cell cycle progression. Our investigations center around a family of conserved enzymes known as cyclin-dependent kinases (and related proteins), which have been shown to be central to control of cell division in all eukaryotic organisms. For these studies we use model systems ranging from yeast, to mice to human cells in culture and methodologies ranging from genetic analysis, to cytological analysis and biochemistry. Much of our recent work has focused on the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis and neurodegenerative diseases.

Selected References 
Spruck CH, de Miguel MP, Smith AP, Ryan A, Stein P, Schultz RM, Lincoln AJ, Donovan PJ, Reed SI. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.Science. 300:647-50. 2003


Morris MC, Kaiser P, Rudyak S, Baskerville C, Watson MH, Reed SI. Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature. 423:1009-13. 2003

Ekholm-Reed S, Mendez J, Tedesco D, Zetterberg A, Stillman B, Reed SI.Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol. 165:789-800. 2004

Strohmaier, H., C. H. Spruck, P. Kaiser, K. A. Won, O. Sangfelt and S. I. Reed (2001).Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line, Nature, 413:316-322.