Faculty

Paul Russell 
Professor
Department of Molecular Biology
TSRI - 1987

Joint Appointments 
CELL BIOLOGY

Education 
Ph.D., University of Washington, 1982

Awards & Activities 
Editorial Board, Genetics

Research Focus 
Preservation of Genome Integrity; Cellular Responses to Environmental Toxins
Understanding how cells respond to genotoxic and cytotoxic stress is essential for developing new strategies to prevent and treat cancer and many other diseases. We investigate these mechanisms in fission yeast, an experimental organism ideally suited for high throughput genetic screens, proteomic analysis of protein complexes, whole genome expression analysis by microarray, chromatin immunoprecipitation, and live cell imaging of signaling proteins by deconvolution microscopy.

Selected References 
Boddy, M. N., Gaillard, P.-H. L., McDonald, W. H., Shanahan, P., Yates, J. R., Russell, P. Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107:537-548, 2001.

Saitoh, S., Chabes, A., McDonald, W. H., Thelander, L., Yates, J. R. 3rd, Russell, P. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109:563-573, 2002.

Rodriguez-Gabriel, M.A., Burns, G., McDonald, W.H., Martin, V., Yates, J. R. 3rd, Bahler, J. Russell, P. RNA binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J. 22:6256-6266, 2003.

Du, L.-L., Nakamura, T.M., Russell, P. (2006) Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev. 20:1583-1596, 2006.