Faculty

Peter Kuhn 
Associate Professor
Department of Cell Biology
TSRI - 2002

Education 
Vordiplom, Julius Maximilians Universität Würzburg, Germany, 1992

M.S., State University of New York at Albany, Albany, NY, 1993

Ph.D., State University of New York at Albany, Albany, NY, 1995

Research Focus 
• Early stage cancer diagnostic through a novel rare cell detection method
• Functional and Structural Proteomics of SARS CoV related proteins
• Modulating protein-protein interactions with tool compounds
• Innovation and implementation of high-throughput biophysical and physical chemistry approaches in basic science and medicine.
• Transdisciplinary R&D bridging across engineering and life sciences
• Proteomics and large scale biology discovery and technology programs using data centric experimentation approaches
• Structure based drug discovery
• Structural and functional genomics utilizing highly automated systems for target selection, sample preparation, and structure determination

Selected References 
Hsieh HB, Marinucci D, Bethel K, Curry DN, Humphrey M, Krivacic RT, Kroener J, Kroener L, Ladanyi A, Lazarus N, Kuhn P, Bruce RH, Nieva J. High speed detection of circulating tumor cells. Biosensors and Bioelectronics 2006;21:1893-1899.

Chrencik JE, Brooun A, Kraus ML, Recht MI, Kolatkar AR, Han GW, Seifert JM, Widmer H, Auer M, Kuhn P. Structural and Biophysical Characterization of the EphB4-EphrinB2 Protein-Protein Interaction and Receptor Specificity. J Biological Chemistry 2006;281:28185-28192.

Brooun A, Foster SA, Chrencik JE, Chien EYT, Kolatkar AR, Streiff M, Ramage P, Widmer H, Weckbecker G, Kuhn P. Remedial Strategies in structural proteomics: Expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expression and Purification, in press (2007), [Epub ahead of print].

Marrinucci D, Bethel K, Bruce RH, Curry DN, Hsieh B, Humphrey M, Krivacic RT, Kroener J, Kroener L, Ladanyi A, Lazarus NH, Nieva J, Kuhn P. Case study of the morphologic variation of circulating tumor cells. Human Pathology, in press (2007), [Epub ahead of print].