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Industrial Research Collaborations and Technology Transfer

More than 20 years ago, the passage of the Bayh-Dole Act -- granting academic research institutions the right to retain and license discoveries made with federal support -- paved the way for the explosion of the biotechnology industry and had a profound effect on the scientific community as a whole in this country. Further, the act stipulated that recipients of government research funding find suitable industrial partners to make its discoveries available to the public in an expeditious manner.

At TSRI the insights of the scientific staff continue to expand the frontiers of biology and medicine by contributing knowledge leading to the understanding of the basic mechanisms of biological systems, as well as discoveries and inventions that may lead to the development of new products to prevent, diagnose and treat human disease. For more than ten years the Institute's scientists have been filling the technology pipeline with new discoveries at an accelerated pace, as licensing agreements and other relationships have been forged with scores of pharmaceutical and biotechnology companies. As a result of these efforts, new health care products are beginning to emerge. Leustatin, an anti-lymphoid medication developed at tested at Scripps, has been approved by the Food and Drug Administration for the treatment of hairy cell leukemia, and continues to show promise as a treatment for multiple sclerosis. Other potent cancer fighting drugs are being studied in the Institute's laboratories and in collaboration with numerous industrial partners, as are new methods to treat infectious diseases, neurological disorders and vascular diseases.

Since the early 1980s, the number of biotechnology companies, potential partners for technology transfer, has skyrocketed from a handful of emerging companies to well over two thousand, each focused on new therapeutics, prophylactics, diagnostics, or the drug discovery process. The success of the technology transfer enterprise at TSRI lies in its ability to forge meaningful collaborations with the biotechnology industry while maintaining its relationships with large pharmaceutical partners. TSRI has entered into hundreds of technology licensing agreements with numerous biotechnology companies, including more than 30 companies which originated from TSRI research. In addition, to these license agreements, we continue to enjoy a robust relationship with the biotech industry through sponsored research agreements and material transfer agreements.

Further, to ensure and perpetuate fair access to the small business community, The Institute established an Office of Small Business Collaborations whose purpose is to seek and promote opportunities for scientific collaborations at TSRI suitable for small business and administer a "Small Business Fund" to benefit small business collaborations.

In addition, TSRI has developed research collaboration agreements with leaders in the pharmaceutical and chemical industries, including Johnson & Johnson, PPG Industries, and Novartis. These arrangements not only provide an efficient mechanism for the smooth transfer of basic scientific inventions into useful medical products and pharmaceuticals, but provides the Institute with access to funds to maintain its infrastructure -- construction of state-of-the-art facilities, purchase of sophisticated instrumentation -- that are no longer available from the National Institutes of Health or other federal agencies.

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