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Corwin Nycholat, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, CB-216 La Jolla, CA 92037 858-784-7539(phone) 858-784-7542 (FAX) nycholat@scripps.edu |
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EDUCATION: June 2008 - Ph. D. Organic Chemistry, University of Alberta, Edmonton, AB (Canada) 2001 - M.Sc. University of Saskatchewan, Saskatoon, SK (Canada) 1997 - BSA. University of Saskatchewan, Saskatoon, SK (Canada) PROFESSIONAL EXPERIENCES: July 2011 to Present - Director for Carbohydrate Synthesis Core (Programs of Excellence in Glycosciences), The Scripps Research Institute, La Jolla, CA, USA July 2011 to Present - Senior Research Associate, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) Jan 2008 to 2011 - Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) 2002 to 2008 - Doctoral Candidate, University of Alberta, Canada (Advisor: Prof. David R. Bundle) 2001 to 2007 - Teaching Assistant, University of Alberta, Canada 2002 - Research Assistant, University of Alberta, Canada 2001 - Research Assistant, University of Saskatchewan, Canada 1998 to 2001 - M. Sc., University of Saskatchewan, Canada (Advisor: Prof. Soledade Pedras) 1998 to 2000 - Teaching Assistant, University of Saskatchewan, Canada 1997 - Research Technician, Agriculture and Agri-Food Canada (Supervisor: Dr. Wes Taylor) 1996 to 1997 - Undergraduate Research Assistant, University of Saskatchewan, Canada (Supervisor: Prof. Malcolm Devine) ACADEMIC AND PROFESSIONAL HONORS: 2005-2006: University of Alberta Graduate Students Association Teaching Award 2004-2005: University of Alberta Teaching Services Graduate Student Teaching Award. 2004 & 2005: Judge for Edmonton Regional Science Fairs. 2002-2003: Co-founder/Organizer of the 1st Banff Symposium on Organic Chemistry; a student organized event showcasing graduate research across Canada and featuring keynote lectures by internationally renowned chemists. Supported by industrial and academic funding and attended by 120 paid registrants. 2002: Alberta Research Council Graduate Entrance Scholarship for Carbohydrate Chemistry. 1998: Dr. & Mrs. E.M. von Rudloff Bursary. University of Saskatchewan. PUBLICATIONS: Zhu, X., McBride, R., Nycholat, C.M., Yu, W., Paulson, J.C., and Wilson, I.A. (2012) Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic acid receptors. J Virol. 86:13371-13383. Peng, W., Pranskevich, J., Nycholat, C., Gilbert, M., Wakarchuk, W., Paulson, J.C., and Razi, N. (2012) Helicobacter pylori b1,3-N-acetylglucosaminyltransferase for versatile synthesis of type 1 and type 2 poly LacNAcs on N-linked, O-linked and I-antigen glycans. Glycobiology. 22(11):1453-1464. Bundle, D.R., Nycholat, C., Costello, C., Rennie, R., and Lipinski, T. (2012) Design of a Candida albicans disaccharide conjugate vaccine by reverse engineering a protective monoclonal antibody. ACS Chemical Biology. 7(10): 1754-1763. Nycholat, C., Rademacher, C., Kawasaki, N., and Paulson, J.C. (2012) In silico aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J. Am. Chem. Soc. 134:15696-99. Rhee, J-K., Baksh, M., Nycholat, C., Gilbert, Paulson, J.C., Kitagishi, H., and Finn, MG. (2012) Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy. Biomacromolecules. 13(8):2333-8. Xu, R., Zhu, X., McBride, R., Nycholat, C.M., Yu, W., Paulson, J.C., and Wilson, I.A. (2012) Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. J Virol. 86(17):9221-32. Rademacher, C., Bru, T., McBride, R., Robison, E., Nycholat, C.M., Kremer, E.J., and Paulson, J.C. (2012) A Siglec-like sialic acid binding motif revealed in an adenovirus capsid protein. Glycobiology. 22(8):1086-91. Chen, W.C., Kawasaki, N., Nycholat, C., Han, S., Pilotte, J., Crocker, P.R., and Paulson, J.C. (2012) Antigen delivery to macrophages using liposomal nanoparticles sargeting Sialoadhesin/CD169. PLoS One. 7(6):e39039. Nycholat, C.M., McBride, R., Ekiert, D.C., Xu, R., Rangarajan, J., Peng, W., Razi, N., Gilbert, M., Wakarchuk, W., Wilson, I.A., and Paulson, J.C. (2012) Recognition of Sialylated Poly-N-acetyllactosamine Chains on N- and O-Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins. Angew Chem Int Ed Engl. 51(20):4860-63. Xu, R., McBride, R., Nycholat, C.M., Paulson, J.C. & Wilson, I.A. (2012). Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. J Virol. 86(2):9. Rhee, J.K., Hovlid, M., Fiedler, J.D., Brown, S.D., Manzenrieder, F., Kitagishi, H., Nycholat, C., Paulson, J.C. & Finn, M.G. (2011). Colorful Virus-like Particles: Fluorescent Protein Packaging by the Qbeta Capsid. Biomacromolecules. 12(11):3977-81. Zeng, Y., Rademacher, C., Nycholat, C.M., Futakawa, S., Lemme, K., Ernst, B. & Paulson, J.C. (2011). High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett. 21, 5045-9. Nycholat, C. M. & Bundle, D. R. (2009). Synthesis of monodeoxy and mono-O-methyl congeners of methyl-b-D-mannopyranosyl-(1->2)-b-D-mannopyranoside for epitope mapping of anti-Candida albicans antibodies. Carbohydr Res 344, 555-69. Shukla, A., Nycholat, C., Subramanian, M. V., Anderson, R. J. & Devine, M. D. (2004). Use of resistant ACCase mutants to screen for novel inhibitors against resistant and susceptible forms of ACCase from grass weeds. J Agric Food Chem 52, 5144-50. Pedras, M. S., Nycholat, C. M., Montaut, S., Xu, Y. & Khan, A. Q. (2002). Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip. Phytochemistry 59, 611-25. |
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