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Matthew Macauley, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, MEM-L71 La Jolla, CA 92037 858-784-9668(phone) 858-784-9690 (FAX) e-mail: mmacaule@scripps.edu |
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EDUCATION: 2010 - Ph. D. Biochemistry, Simon Fraser University, Burnaby, British Columbia (Canada) 2003 - B.S. Biochemistry, University of British Columbia (Canada) PROFESSIONAL EXPERIENCES: June 2010 to Present - Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) September 2004 to May 2010 - Doctoral Candidate, Department of Chemistry @ Simon Fraser University, Burnaby, British Columbia, Canada (Advisor: Prof. David J. Vocadlo) May 2002 to September 2004 - Research Technician, Department of Biochemistry @ University of British Columbia, Canada (Supervisor: Dr. L.P. McIntosh) ACADEMIC AND PROFESSIONAL HONORS: 2010-2013: Human Frontier Science Program Organization (HFSPO) - Doctoral Fellowship 2011: The CCUCC (Canadian Council of University Chemistry Chairs) Doctoral Thesis Award 2011: AAI (American Association of Immunologists) - travel award 2008: Simon Fraser University Chemistry Poster Competition - poster prize 2006-2009: Natural Sciences and Engineering Research Council of Canada (NSERC) - Canadian Graduate Fellowship (PhD) 2007-2009: Michael Smith Foundation for Health Research - Senior Trainee Fellowship 2006: Merck Frosst Research Day - selected as a participant 2006: XXIIIrd International Carbohydrate Symposium - poster prize 2005-2006: Natural Sciences and Engineering Research Council of Canada (NSERC) - Canadian Graduate Fellowship (Masters) 2005: PENCE Annual Research Conference - poster prize 2005-2007: Michael Smith Foundation for Health Research - Junior Trainee Fellowship 2003: UBC Faculty of Medicine - Summer Research Scholarship 2002: UBC Undergraduate Research Conference - poster prize PUBLICATIONS: Paulson JC, Macauley MS, Kawasaki N. Siglecs as sensors of self in innate and adaptive immune responses. Ann N Y Acad Sci. 2012 Apr;1253(1):37-48.[PMID: 22288608] 22. Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadl DJ. Incraing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012; 8(4):393-9. [PMID: 22366723] Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ. Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chem Biol. 2010;17(9):949-58. [PMID: 20851344] Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol. 2010;17(9):937-48. [PMID: 20851343] Macauley MS, Vocadlo DJ. Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochim Biophys Acta. 2010;1800(2):107-21. [PMID: 19664691] He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc. 2010;132(6):1807-9. [PMID: 20067256] Stubbs KA, Macauley MS, Vocadlo DJ. A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angew Chem Int Ed Engl. 2009;48(7):1300-3. [PMID: 19130519] Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A. 2009;106(32):13427-32. [PMCID: PMC2726349] Macauley MS, Vocadlo DJ. Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase. Carbohydr Res. 2009;344(9):1079-84. [PMID: 19423084] Greig IR, Macauley MS, Williams IH, Vocadlo DJ. Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships. J Am Chem Soc. 2009;131(37):13415-22. [PMID: 19715310] Abbott DW, Macauley MS, Vocadlo DJ, Boraston AB. Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. J Biol Chem. 2009;284(17):11676-89. [PMCID: PMC2670171] Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008;4(8):483-90. [PMID: 18587388] Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol. 2008;15(7):764-5. [PMID: 18536723] Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ. Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem. 2008;283(50):34687-95. [PMID: 18842583] Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J Am Chem Soc. 2007;129(3):635-44. [PMID: 17227027] Stubbs KA, Macauley MS, Vocadlo DJ. A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides. Carbohydr Res. 2006;341(10):1764-9. [PMID: 16472788] Sheldon WL, Macauley MS, Taylor EJ, Robinson CE, Charnock SJ, Davies GJ, Vocadlo DJ, Black GW. Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. Biochem J. 2006;399(2):241-7. [PMCID: PMC1609908] Macauley MS, Errington WJ, Scharpf M, Mackereth CD, Blaszczak AG, Graves BJ, McIntosh LP. Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J Biol Chem. 2006;281(7):4164-72. [PMID: 16319071] Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol. 2006;13(4):365-71. [PMID: 16565725] Cetinbas N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ. Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry. 2006;45(11):3835-44. [PMID: 16533067] Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ. O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. J Biol Chem. 2005;280(27):25313-22. [PMID: 15795231] Macauley MS, Stubbs KA, Vocadlo DJ. O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. J Am Chem Soc. 2005;127(49):17202-3. [PMID: 16332065] Macauley MS, Errington WJ, Okon M, Scharpf M, Mackereth CD, Schulman BA, McIntosh LP. Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. J Biol Chem. 2004;279(47):49131-7. [PMID: 15355965] PATENTS: Vocadlo, DJ, McEachern EJ, Macauley MS; Whitworth G, Heinonen J, Li T, Stubbs K. 'Selective glycosidase inhibitors and uses thereof' PCT Int. Appl. WO 2008025170, 2008 . Vocadlo DJ, Macauley MS, Whitworth G. 'Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof' PCT Int. Appl. WO 2006092049, 2006. |
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