the
Patapoutian
lab bibliography
main_image

    Selected research articles:

    Syeda R, Qiu Z, Dubin AE, Murthy SE, FLorendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A (2016) LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Cell 164:499-511

    Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Francisco A, Jessell TM, Wilkinson KA, Patapoutian A (2015) Piezo2 is the principal mechanotransduction channel for proprioception. Nature Neurosci 18:1756-65

    Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan SM, Kim HJ, Bandell M, Longo N, Day RW, Stevenson DA, Patapoutian A, Krock BL (2015) Impaired Piezo1 function in patients with a novel autosomal recessive cogenital lymphatic dysplasia. Nature Communications 6:8329

    Cahalan S, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A (2015) Piezo1 links mechanical forces to red blood cell volume. eLife 10.7554/eLife.07370

    Syeda R, Xu J, Dubin A, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A (2015) Chemical activation of the mechanotransduction channel Piezo1. eLife 10.7554/eLife.0369

    Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A (2015) Piezo1 ion channel pore properties are dictated by C-terminal region. Nature Communications 6:7223

    Wieskopg JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Leseter HA, Patapoutian A, Mogil JS (2015) The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Translational Medicine 7:287

    Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Begay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A (2014) Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature 516:121-5.

    Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian, A (2014) Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci USA 111:10347-52.

    Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A. (2014) Piezo2 is required for Merkel cell mechanotransduction. Nature doi: 10.1038/nature13251.

    Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A. (2014) SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell 157(2):447-58.

    Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL, Wellnitz SA, Firozi P, Woo SH, Ranade S, Patapoutian A, Lumpkin EA. (2014) Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature doi: 10.1038/nature13250.

    Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Feneant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garcon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A. (2013) Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nature Communications 4:1884.

    Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, Steen VM, Mathur J, Cox J, Lebo M, Rehm H, Weiss ST, Wood JN, Maas RL, Sunyaev SR, Patapoutian A (2013) Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci 110:4667-72.

    Dubin AE, Schmidt M, Mathur J, Petrus MJ, Xiao B, Coste B, Patapoutian A (2012) Inflammatory signals enhance piezo2-mediated mechanosensitive currents. Cell Reports 2:511-7.

    Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A. (2012) Piezos are pore-forming subunits of mechanically activated channels. Nature Feb 19. doi: 10.1038/nature10812.

    Kim SE, Coste B, Chadha A, Cook B, Patapoutian A. (2012) The role of Drosophila Piezo in mechanical nociception. Nature Feb 19. doi: 10.1038/nature10801.

    Xiao B, Coste B, Mathur J, Patapoutian A. (2011) Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression. Nature Chemical Biology 7:351-8.

    Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. (2010) Piezo1 and Piezo2 are essential components of distinct mechanically-activated cation channels. Science 330: 55-6.

    Grandl J, Kim SE, Uzzell V, Bursulaya B, Petrus M, Bandell M, Patapoutian A. (2010) Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nature Neuroscience 13: 708-14.

    Schmidt M, Dubin A, Petrus M, Earley T, Patapoutian A. (2009) Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64:498-509.

    Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A. (2009) Zinc activates damage-sensing TRPA1 ion channels. Nature Chemical Biology 5:183-90.

    Grandl J, Hu H, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A. (2008) Pore region of TRPV3 ion channel is specifically required for heat-activation. Nature Neuroscience 11: 1007-13.

    Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. (2007) TRPM8 is Required for Cold Sensation in Mice. Neuron 54: 371-8.

    Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A. (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-5.

    Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A. (2006) High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature Neuroscience 9:493-500.

    Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KSR, Andahazy M, Story G, Patapoutian A. (2005) Impaired thermosensation in Mice Lacking TRPV3, a Heat-Sensing channel in skin. Science 307: 1468-72.

    Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A. (2004) Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin. Neuron 41:849-57.

    Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VL, Hwang SW, Patapoutian A,* and Jegla T.* (2003) Opposite thermosensor in fruitfly and mouse. Nature 423: 822-3 (co-corresponding authors).

    Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Bevan S, Patapoutian A. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112: 819-829.

    Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A. (2002) A novel heat-sensitive TRP channel expressed in keratinocytes. Science 296: 2046-9.

    Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A. (2002) A Trp Channel that Senses Cold Stimuli and Menthol. Cell 108: 705-715.

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