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Research Articles

Huitron-Resendiz, S. Henriksen, S.J., Barr, M.C., Testa, M.P., Crawford, E., Parsons, L.H., Sanchez, M., Phillips, T.R. (2010) Methamphetamine and lentivirus interactions: reciprocal enhancement of CNS disease. Journal of NeuroVirology 16, 268-278 (PMID: 20608774).

Ramchandani, V.A., Umhau, J., Pavon, F.J., Ruiz-Velasco, V., Margas, W., Sun, H., Damadzic, R., Eskay, R., Schoor, M., Thorsell, A., Schwandt, M.L., Sommer, W.H., George, D.T., Parsons, L.H., Herscovitch, P., Hommer, D., Heilig, M. (2010) A genetic determinant of the striatal dopamine response to alcohol in men. Molecular Psychiatry (Epub May 18) (PMID: 20479755).

Roberto, M., Cruz, M.T., Bajo, M., Siggins, G.R., Parsons, L.H., Schweitzer, P. (2010) The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala. Neuropsychopharmacology 35, 1962-1972 (PMID: 20463657).

Plaza-Zabala, A., Berrendero, F., Suarez, J., Bermudez-Silva, F.J., Fernandez-Espejo, E., Serrano, A., Pavon, F.J., Parsons, L.H., Rodriguez de Fonseca, F., Maldonado, R., Robledo, P. (2010) Effects of the endogenous PPAR-a agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice. Synapse 64, 379-389 (PMID: 20029832).

Roberto, M., Cruz, M.T., Gilpin, N.W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S.M., Stouffer, D., Zorrilla, E.P., Koob, G.F., Siggins, G.R., Parsons, L.H. (2010) Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence. Biological Psychiatry 67, 831-839 (PMID: 20060104).

Qu, Y., Saint Marie, R.L., Breier, S., Ko, D., Stouffer, D., Parsons, L.H., Swerdlow, N.R. (2009) Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague Dawley and Long Evans rats. Psychopharmacology 207, 271-280 (PMID: 19756524).

Neumaier, J.F., McDevitt, R.A., Polis, I.Y., Parsons, L.H. (2009) Acquisition of and withdrawal from cocaine self-administration regulates 5-HT1B mRNA expression in rat striatum. Journal of Neurochemistry 111, 217-227 (PMID: 19659573).

Alvarez-Jaimes, L., Polis, Y., Parsons, L.H. (2009) Regional influence of CB1 receptor signaling on ethanol self-administration by rats. The Open Neuropsychopharmacology 2, 77-85. Alvarez-Jaimes, L. Stouffer, D.G., L, Parsons, L.H. (2009)

Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. Journal of Neurochemistry 111, 37-48 (PMID: 19650871).

Abdallah, L., Bonasera, S.J., Hopf, W., O’Dell, L., Giorgetti, M., Jongsma, M., Carra, S., Pierucci, M., Di Giovanni, G., Esposito, E., Parsons, L.H., Bonci, A., Tecott, L.H. (2009) Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. The Journal of Neuroscience 29, 8156-8165 (PMID: 19553455).

Villanueva, A., Yilmaz, M.S., Millington, W.R., Cutrera, R.A., Stouffer, D.G., Parsons, L.H., Cheer, J.F., Feleder, C. (2009) Central cannabinoid-1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Shock 32, 614-620 (PMID 19295473).

Orio, L., Edwards, S., George, O., Parsons, L.H., Koob, G.F. (2009) A role for the endocannabinoid system in the increased motivation for cocaine in dependence. The Journal of Neuroscience 29, 4846-4857 (PMID: 19369553).

Poceta, J.S., Parsons, L.H., Engelland, S., Kripke, D.F. (2009) Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson’s disease. Sleep Medicine 10, 129-133 (PMID: 18207455).

Long, J.Z., Li, W, Booker, L., Burston, J.J., Kinsey, S.G., Schlosburg, J.E., Pavon, F.J., Serrano, A.M., Selley, D.E., Parsons, L.H., Lichtman A.H., Cravatt, B.F. (2009) Selective pharmacological blockade of 2-arachidonoylglycerol hydrolysis produces profound cannabinoid behavioral effects. Nature Chemical Biology 5, 37-44 (PMID: 19029917).

Qu, Y., Swerdlow, N.R., Weber, M., Stouffer, D. and Parsons, L.H. (2008) Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies. Pharmacology, Biochemistry and Behavior, 90, 686-690 (PMID: 18579193).

Alvarez-Jaimes, L., Polis, I. and Parsons, L.H. (2008) Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB1 antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala. Neuropsychopharmacology, 33, 2483-2493 (PMID: 18059440).

George, O., Ghozland, S., Azar, M.R., Cottone, P., Zorrilla, E.P., Parsons, L.H., O’Dell, L.E., Richardson, H.N. and Koob, G.F. (2007) CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences, 104, 17198-17203 (PMID: 17921249).

Caillé, S., Alvarez, L., Polis, I., Stouffer, D. and Parsons, L.H. (2007) Specific alterations of extracellular endocannabinoid levels in nucleus accumbens by ethanol, heroin and cocaine self-administration. The Journal of Neuroscience, 27, 3695-3702 (PMID: 17409233).

Ferrer, B., Bermudez-Silva, J., Bilbao A., Alvarez-Jaimes, L., Sanchez-Vera, I., Giuffrida, A., Serrano, A., Baixeras, E., Navarro, M., Parsons, L.H., Piomelli, D., Rodriguez de Fonseca, F. (2007) Regulation of brain anandamide by acute administration of ethanol. Biochemical Journal, 404, 97-104 (PMID: 17302558).

Frantz, K.J., O’Dell, L.E. and Parsons, L.H. (2007) Behavioral and neurochemical responses to cocaine in periadolescent and adult rats. Neuropsychopharmacology, 32, 625-637 (PMID: 16794567).

Selvage, D.J., Parsons, L., Rivier, C. (2006) Role played by brain stem neurons in regulating testosterone secretion via a direct neuronal pathway between the hypothalamus and the testes. Endocrinology, 147, 3070-3075 (PMID: 16556770).

Guillem, K., Vouillac, C., Azar, M.R., Parsons L.H., Koob, G.F., Cador, M. and Stinus, L. (2006) Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. European Journal of Neuroscience, 24, 3532-3540 (PMID: 17229101).

O'Dell, L.E., Bruijnzeel, A.W., Smith, R.T., Parsons, L.H., Merves, M.L., Goldberger, B., Koob, G.F. and Markou, A. (2006) Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology, 186, 612-619 (PMID: 16598454).

O’Dell, L.E., Manzardo A., Polis, I., Stouffer, D.G. and Parsons, L.H. (2006) Biphasic alterations in 5-HT1B receptor function during abstinence from extended cocaine self-administration. Journal of Neurochemistry, 99, 1363-1376 (PMID: 17074068).

Caillé, S. and Parsons, L.H. (2006) Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology, 31, 804-813 (PMID: 16123766).

Guillem, K., Vouillac, C., Azar, M.R., Parsons, L.H., Koob, G.F., Cador, M. and Stinus, L. (2005) Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. The Journal of Neuroscience, 25, 8593-8600 (PMID: 16177026).

Madden, L.J., Flynn, C.T., Zandonatti, M., May, M., Katner, S., Parsons, L.H., Henriksen, S.J. and Fox, H.S. (2004) Modeling human methamphetamine abuse in non-human primates: chronic dosing of rhesus macaques leads to behavioral and physiological abnormalities. Neuropsychopharmacology, 30, 350-359 (PMID: 15483561).

O’Dell, L.E. and Parsons, L.H. (2004) Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of Pharmacology and Experimental Therapeutics, 311, 711-719 (PMID: 15226384).

Roberto, M., Madamba, S.G., Stouffer, D.G., Parsons L.H. and Siggins, G.R. (2004) Increased GABA Release in the Central Amygdala of Ethanol Dependent Rats. The Journal of Neuroscience, 24, 10159-10166 (PMID: 15537886).

Roberto, M., Madamba, D., Stouffer, D.G., Parsons L.H. and Siggins, G.R. (2004) Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. The Journal of Neuroscience, 18, 1594-1603 (PMID: 14973247).

Caillé, S. and Parsons, L.H. (2004) Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats. European Journal of Neuroscience, 20, 593-596 (PMID: 15233770).

Selvage, D.J., Lee, S., Parsons, L.H., Seo, D.O. and Rivier, C. (2004). A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow. Endocrinology, 145, 1750-1759 (PMID: 14684600).

Taffe, M.A., Huitrón-Resendiz, S., Schroeder, R., Parsons, L.H., Henriksen, S.J. and Gold, L.H. (2003) MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys, Pharmacology Biochemistry and Behavior, 76, 141-152 (PMID: 13679227).

Ahmed, S.H., Lin, D., Stouffer, D., Koob, G.F. and Parsons, L.H. (2003) The effect of cocaine on nucleus accumbens dopamine levels is unaltered during escalation of cocaine self-administration. Journal of Neurochemistry, 86, 102-113 (PMID: 12807430).

Caillé, S. and Parsons, L.H. (2003) SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats. European Journal of Neuroscience, 18, 3145-3149 (PMID: 14656311).

Lin, D. and Parsons, L.H. (2002) Anxiogenic-like effect of serotonin1B receptor stimulation in the rat on the elevated plus-maze. Pharmacology Biochemistry and Behavior, 71, 581-587 (PMID: 11888549).

Taffe, M., Davis, S., Yuan, J., Schroeder, R., Hatzidimitriou, G., Parsons, L.H., Ricaurte, G. and Gold, L. (2002) Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology, 27, 993-1005 (PMID: 12464456).

Frantz, K.J., Hansson, K.J., Stouffer, D.G. and Parsons, L.H. (2002) 5-HT6 receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine. Neuropharmacology, 42, 170-180 (PMID: 11804613).

Rocha, B.A., Goulding E.H., O’Dell, L.E., Mead, A.N., Coufal, N.G., Parsons, L.H. and Tecott, L.H. (2002) Enhanced behavioral, reinforcing, and neurochemical effects of cocaine in serotonin 5-HT2C receptor mutant mice. The Journal of Neuroscience, 22, 10039-10045 (PMID: 12427861).

Taffe, M.A., Weed, M.R., Davis, S., Huitrón-Resendiz, S., Schroeder, R., Parsons, L.H., Henriksen, S. and Gold, L.H. (2001) Functional consequences of repeated (±)3,4 methylenedioxymeth-amphetamine (MDMA) treatment in rhesus monkeys. Neuropsychopharmacology, 24, 230-239 (PMID: 11166514).

Parsons, L.H., Kerr, T.M. and Tecott, L.H. (2001) 5-HT1A receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission. Journal of Neurochemistry, 77, 607-617 (PMID: 11299323).

Weiss, F., Maldonado-Vlaar, C.S., Parsons, L.H., Kerr, T.M., Smith, D.L. and Ben-Shahar, O. (2000) Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences, 97, 4321-4326 (PMID: 10760299).

Solbrig, M.V., Koob, G.F., Parsons, L.H., Kadota, T., Horscroft, N., Briese, T. and Lipkin, I. (2000) Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability. The Journal of Neuroscience 20, RC104-108 (PMID: 11050146).

Parsons, L.H., Koob, G.F. and Weiss, F. (1999) RU 24969, a mixed 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse, 32, 132-135 (PMID: 10231132).

Harrison, A.A., Parsons, L.H., Koob, G.F. and Markou, A. (1999) RU 24969, a 5-HT1A/1B agonist, decreases brain stimulation reward: an effect reversed by GR 127935, a selective 5-HT1D/1B antagonist. Psychopharmacology, 141, 242-250 (PMID: 10027505).

Giuffrida, A., Parsons, L.H., Kerr, T.M., Rodriguez de Fonseca, F., Navarro, M. and Piomelli D. (1999) Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neuroscience, 2, 358-363 (PMID: 10204543).

Heisler, L.K., Chu, H.-M., Brennan, T., Danao, J., Bajwa P., Parsons, L.H. and Tecott, L.H. (1998) Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences, 95, 15049-15054 (PMID: 9844013).

Parsons, L.H., Weiss, F. and Koob, G.F. (1998) Serotonin1B receptor stimulation enhances cocaine reinforcement. The Journal of Neuroscience, 18, 10078-10089 (PMID: 9822762).

Parsons, L.H. and Weiss, F. (1998) Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. Journal of Chromatography B, 709, 35-45 (PMID: 9653924).

Caine, S.B., Koob, G.F., Parsons, L.H., Everitt, B.J., Schwartz, J.-C. and Sokoloff, P. (1997) D3 receptor test in vitro predicts decreased cocaine self-administration in rats. NeuroReport, 8, 2373-2377 (PMID: 9243643).

Raber, J., Mehta, P.P., Kreifeldt, M, Parsons, L.H., Weiss, F., Bloom, F.E. and Wilson, M.C. (1997) Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission. Journal of Neurochemistry, 68, 176-186 (PMID: 8978724).

Parsons, L.H., Weiss, F. and Koob, G.F. (1996) Serotonin-1B receptor stimulation enhances dopamine-mediated reinforcement. Psychopharmacology, 128, 150-160 (PMID: 8956376).

Weiss, F., Parsons, L.H., Schulteis, G., Hyytiä, P., Lorang, M.T., Bloom, F.E. and Koob, G.F. (1996) Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. The Journal of Neuroscience, 16, 3474-3485 (PMID: 8627380).

Parsons, L.H., Caine, S.B., Sokoloff, P, Schwartz, J.-C., Koob, G.F. and Weiss, F. (1996) Neurochemical evidence that post-synaptic nucleus accumbens D3 receptor stimulation potentiates cocaine reinforcement. Journal of Neurochemistry, 67, 1078-1089 (PMID: 8752115).

Parsons, L.H., Koob, G.F. and Weiss, F. (1996) Extracellular 5-HT is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural Brain Research, 73, 225-228 (PMID: 8788507).

Carrera, M.R.A., Ashley, J.A., Parsons, L.H., Wirsching, P.M., Koob, G.F., and Janda, K.D. (1995) Suppression of psychoactive effects of cocaine by active immunization. Nature, 378, 727-730 (PMID: 7501020).

Parsons, L.H., Koob, G.F. and Weiss, F. (1995) Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. The Journal of Pharmacology and Experimental Therapeutics, 274, 1182-1191 (PMID: 7562486).

Olson-Cosford, R.J., Parsons, L.H. and Justice, J.B., Jr. (1994) Effect of tetrodotoxin and potassium infusion on microdialysis extraction fraction and extracellular dopamine in the nucleus accumbens. Neuroscience Letters, 178, 175-178 (PMID: 7824191).

Parsons, L.H. and Justice, J.B., Jr. (1993) Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area and dorsal raphé nucleus following repeated cocaine administration. Journal of Neurochemistry, 61, 1611-1619 (PMID: 7693863).

Parsons, L.H., Schad, C.A. and Justice, J.B., Jr. (1993) Co-administration of the D2 antagonist pimozide inhibits upregulation of dopamine release and uptake induced by repeated cocaine. Journal of Neurochemistry, 60, 376-379 (PMID 8417161).

Parsons, L.H. and Justice, J.B., Jr. (1993) Perfusate serotonin increases extracellular dopamine in the nucleus accumbens of the rat as measured by in vivo microdialysis. Brain Research, 606, 195-199 (PMID: 8490716).

Parsons, L.H. and Justice, J.B., Jr. (1992) Extracellular concentration and in vivo recovery of dopamine in the nucleus accumbens using microdialysis. Journal of Neurochemistry, 58, 212-218 (PMID: 1727431).

Parsons, L.H., Smith, A.D. and Justice, J.B., Jr. (1991) Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse, 9, 60-65 (PMID: 1796352).

Parsons, L.H., Smith, A.D. and Justice, J.B., Jr. (1991) The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens. Journal of Neuroscience Methods, 40, 139-147 (PMID: 1800851).

Pettit, H.O., Pan, H.-T., Parsons, L.H. and Justice, J.B., Jr. (1990) Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. Journal of Neurochemistry, 55, 798-804 (PMID 2384752).