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Publications & Patents
1. Pharmaceutically Active 6,9-Thiaprostacyclin Analogs and Derivatives Thereof, K.C. Nicolaou, W.E. Barnette, R.L. Magolda; Serial No. 886,141; U.S. Patent No. 4,291,166 issued Sept. 22, 1981.
2. Cyclic Ethers and Thioethers Including Oxygen Isomers and Sulfur Analogs of Prostacyclin, K.C. Nicolaou, W.E. Barnette, R.L. Magolda, and Z. Lysenko; Serial No. 886,143; U.S. Patent No. 4,258,199 issued Mar. 24, 1981.
3. Pyridaza Prostacyclin Analogs and N-Oxides Thereof, K.C. Nicolaou, W.E. Barnette and R.L. Magolda; Serial No. 20,543; U.S. Patent No. 4,256,883 issued Mar. 17, 1981.
4. Thromboxane A2 Analogs, K.C. Nicolaou, R.L. Magolda; Serial No. 19,932; U.S. Patent No. 4,308,396 issued Dec. 29, 1981.
5. Carbocyclic Thromboxane A2 Analog, K.C. Nicolaou, R.L. Magolda and D.A. Claremon, Serial No. 87,678; U.S. Patent No. 4,260,806 issued Apr. 7, 1981.
6. Carbocyclic Thromboxane A2 Analog, K.C. Nicolaou, R.L. Magolda and D.A. Claremon; Serial No. 194,399; U.S. Patent No. 4,317,935 issued Mar. 2, 1982.
7. Method of Preparing Bicyclo(3.1.1)Hept-2-One, K.C. Nicolaou, R.L. Magolda and D.A. Claremon; Serial No. 289,965; U.S. Patent No. 4,429,166 issued Jan. 31, 1984.
8. Leukotriene A4 Analogs, K.C. Nicolaou, N.A. Petasis and S.P. Seitz; Serial No. 325,553; U.S. Patent No. 4,442,099 issued Apr. 10, 1984.
9. Leukotriene A4 Analogs, K.C. Nicolaou, N.A. Petasis and S.P. Seitz; Serial No. 528,733; U.S. Patent No. 4,567,290 issued Jan. 28, 1986.
10. Alkanoarachidonic Acids, K.C. Nicolaou, N.A. Petasis, W.S. Li, T. Ladduwahetty, J.L. Randall, S.E. Webber and P.E. Hernandez; Serial No. 655,196; U.S. Patent No. 4,873,024 issued Oct. 10, 1989.
11. Method of Synthesizing Leukotriene B4 and Derivatives Thereof, K.C. Nicolaou, Y. Abe; Serial No. 165,521; U.S. Patent No. 4,873,024 issued Oct. 10, 1989.
12. Method of Synthesizing Leukotriene B4 and Derivatives Thereof, K.C. Nicolaou, Y. Abe; Serial No. 388,990; U.S. Patent No. 5,110,949 issued May 5, 1992.
13. Cyclic Conjugated Enediynes, K.C. Nicolaou, Y. Ogawa, G. Zuccarello; Serial No. 214,019; U.S. Patent No. 5,097,062 issued Mar. 17, 1992.
14. Cyclic Conjugated Enediynes, K.C. Nicolaou, Y. Ogawa, G. Zuccarello; Serial No. 803,618; U.S. Patent No. 5,239,118 issued Aug. 24, 1993.
15. Glycolipids, K.C. Nicolaou, T. Caulfield; Serial No. 242,723; U.S. Patent No. 4,977,286 issued Dec. 11, 1990.
16. Sesquiterpene Epoxides and Process for Their Preparation, J.R. Aldrich, J.E. Oliver, K.C. Nicolaou, B.E. Marron; Serial No. 168,047; U.S. Patent No. 4,981,981 issued Jan. 1, 1991.
17. Propargylic and Allenic Sulfones, K.C. Nicolaou, G. Zuccarello, S. Skokotas, P.E. Maligres; Serial No. 470,814; U.S. Patent No. 5,237,101 issued Aug. 17, 1993.
18. Golfomycin Derivatives: Novel Fused Ring Cyclodecadiyne Derivatives Having DNA-Cleaving Properties and Antitumor Activity, K.C. Nicolaou, G. Skokotas; Serial No. 07/561,964; U.S. Patent No. 5,136,099 issued Aug. 4, 1992.
19. Dynemicin Analogs: Synthesis, Methods of Preparation and Use, A.L. Smith, C.-K. Hwang, S. Wendeborn, K.C. Nicolaou, E.P. Schreiner, W. Stahl, W.-M. Dai, P.E. Maligres, T. Suzuki; Serial No. 07/886,984; U.S. Patent No. 5,276,159 issued Jan. 4, 1994.
20. Dynemicin Analogs: Synthesis, Methods of Preparation and Use, A.L. Smith, C.-K. Hwang, S. Wendeborn, K.C. Nicolaou, E.P. Schreiner, W. Stahl, W.-M. Dai, P.E. Maligres, T. Suzuki; Serial No. 07/939,104; U.S. Patent No. 5,281,710 issued Jan. 25, 1994.
21. Dynemicin Analogs: Synthesis, Methods of Preparation and Use, A.L. Smith, C.-K. Hwang, S. Wendeborn, K.C. Nicolaou, E.P. Schreiner, W. Stahl, W.-M. Dai, P.E. Maligres, T. Suzuki; Serial No. 08/184,580; U.S. Patent No. 5,527,805 issued June 18, 1996.
22. Induction of Inhibition of Apoptosis, K.C. Nicolaou, A. Hiatt, W. Wrasidlo; Serial No. 08/046,626; U.S. Patent No. 5,500,432 issued Mar. 19, 1996.
23. Analogs of Calicheamicin γ1I, Method of Making and Using the Same, A.L. Smith, K.C. Nicolaou, C.-K. Hwang, E. Pitsinos, , Serial No. 07/915,071, U.S. Patent No. 5,264,586 issued Nov. 23, 1993.
24. Daunomycin Derivative with Reduced Cytotoxicity Toward Normal Cells, K.C. Nicolaou, W. Wrasidlo, P.E. Maligres, Serial No. 07/922,834, U.S. Patent No. 5,413,992 issued May 9, 1995.
25. Daunomycin Derivative with Reduced Cytotoxicity Toward Normal Cells, K.C. Nicolaou, W. Wrasidlo, P.E. Maligres, Serial No. 08/423,266, U.S. Patent No. 5,643,887 issued Jul. 1, 1997.
26. Intermediates in the Formation of the Calicheamicin and Esperamicin Oligosaccharides, K.C. Nicolaou, R.D. Groneberg, E.P. Schreiner, W. Stahl; Serial No. 07/972,246; U.S. Patent No. 5,384,412 issued Jan. 24, 1995.
27. Phosphene Oxide-Terminated Allene-Ene-Yne DNA Cleaving, Antitumor and Antibiotic Molecules, K.C. Nicolaou, P.E. Maligres; Serial No. 07/561,455; U.S. Patent No. 5,229,375 issued Jul. 20, 1993.
28. Intermediates for Preparation of Taxols, K.C. Nicolaou, C.-K. Hwang, E.J. Sorenson, J.-J. Liu; Serial No. 07/902,390; U.S. Patent No. 5,274,137 issued Dec. 28, 1993.
29. Total Synthesis of Taxol and Taxol Analogs, K.C. Nicolaou, E.J. Sorenson, M. Nakada, Z. Yang; Serial No. 08/197,637; U.S. Patent No. 5,461,169 issued Oct. 24, 1995.
30. Non-Peptide Peptidomimetics, R.F. Hirschmann, K.C. Nicolaou, S. Pietranico, T.D. Reisine, J.M. Salvino, P. Sprengeler, C.D. Strader; Serial No. 08/144,660; U.S. Patent No. 5,552,534 issued Sept. 3, 1996.
31. Water Soluble Taxol Derivatives, K.C. Nicolaou, C.G. Riemer, M.A. Kerr; Serial No. 08/122,722; U.S. Patent No. 5,422,364 issued Jun. 6, 1995.
32. Water Soluble Taxol Derivatives, K.C. Nicolaou, C.G. Riemer, M.A. Kerr; Serial No. 08/395,169; U.S. Patent No. 5,608,087 issued Mar. 4, 1997.
33. Water Soluble Taxol Derivatives, K.C. Nicolaou, C.G. Riemer, M.A. Kerr; Serial No. 08/811,522; U.S. Patent No. 5,817,840 issued Oct. 6, 1998.
34. Designed Quinone- and Hydroquinone-Containing Cyclic Enediyneols and Enediyneones Having DNA Cleaving and Cytotoxic Properties, K.C. Nicolaou, A. Liu; Serial No. 07/938,756; U.S. Patent No. 5,274,141 issued Dec. 28, 1993.
35. Ten-Membered Ring Enediynediols and Enediynediones Having DNA Cleaving Properties, K.C. Nicolaou, E.J. Sorensen, C.-K Hwang, R.D. Discordia, R.G. Bergman, R.E. Minto; Serial No. 07/788,161; U.S. Patent No. 5,183,942 issued Feb. 2, 1993.
36. Open Chain Enediyne Dihydroperoxides Having DNA Cleaving Properties, K.C. Nicolaou, E.J. Sorensen, C.-K Hwang, R.D. Discordia, R.G. Bergman, R. E. Minto; Serial No. 08/010,639; U.S. Patent No. 5,288,761 issued Feb. 22, 1994.
37. Access to Taxol Analogs, K.C. Nicolaou, P.G. Nantermet, R.K. Guy, H. Ueno; Serial No. 08/110,095; U.S. Patent No. 5,440,057 issued Aug. 8, 1995.
38. Access to Taxol Analogs, K.C. Nicolaou, P.G. Nantermet, R.K. Guy, H. Ueno; Serial No. 08/512,229; U.S. Patent No. 5,750,691 issued May 12, 1998.
39. Carbopeptoids and Carbonucleotoids, K.C. Nicolaou; Serial No. 08/913,035; U.S. Patent No. 6,204,376 issued Mar. 20, 2001.
40. Carbopeptoids and Carbonucleotoids, K.C. Nicolaou; Serial No. 09/417,877; U.S. Patent No. 6,384,211 B1 issued May 7, 2002.
41. Transformations of Taxols, K.C. Nicolaou, P.G. Nantermet, R.K. Guy, H. Ueno; Serial No. 08/193,263; U.S. Patent No. 5,504,222 issued Apr. 2, 1996.
42. Transformations of Taxols, K.C. Nicolaou, P.G. Nantermet, R.K. Guy, H. Ueno; Serial No. 08/626,112; U.S. Patent No. 5,786,489 issued Jul. 28, 1998.
43. Transformations of Taxols, K.C. Nicolaou, P.G. Nantermet, R.K. Guy, H. Ueno; Serial No. 09/123,504; U.S. Patent No. 6,043,382 issued Mar. 28, 2000.
44. Water Soluble Oniun Salt of Taxo-Deterpenoid, K.C. Nicolaou, W. Wrasidlo, R.K. Guy, E. Pitsinos; Serial No. 08/817,890; U.S. Patent No. 6,025,491 issued Feb. 15, 2000.
45. Self-Assembled Taxo-Deterpenoid Nanostructures, K.C. Nicolaou, W. Wrasidlo, R.K. Guy, E. Pitsinos; Serial No. 08/913,744; U.S. Patent No. 6,271,384 B1, issued Aug. 7, 2001.
46. Chemical Switching of Taxo-Diterpenoids Between Low Solubility Active Forms and High Solubility Inactive Forms, K.C. Nicolaou, W. Wrasidlo, R.K. Guy, E. Pitsinos; Serial No. 08/750,638; U.S. Patent No. 6,252,094 B1, issued Jun. 26, 2001.
47. Taxoid Synthesis, K.C. Nicolaou, C.F. Claiborne, P.G. Nantermet, E.A. Couladouros, E.J. Sorensen; Serial No. 08/201,926; U.S. Patent No. 5,481,007 issued Jan. 2, 1996.
48. Taxoid Synthesis, K.C. Nicolaou, C.F. Claiborne, P.G. Nantermet, E.A. Couladouros, E.J. Sorensen; Serial No. 08/527,377; U.S. Patent No. 5,760,240 issued Jun. 2, 1998.
49. Calicheamicin Mimics, K.C. Nicolaou, E.N. Pitsinos, Serial No. 08/301,968; U.S. Patent No. 5,550,246 issued Aug. 27, 1996.
50. Formation of Esperamicin Precursors, K.C. Nicolaou, D.A. Clark, Serial No. 08/312,106; U.S. Patent No. 5,504,206 issued Apr. 2, 1996.
51. Epothilone Analogs, K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, Serial No. 08/923,869; U.S. Patent No. 6,441,186 B1, issued Aug. 27, 2002.
52. Epothilone Analogs, K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, Serial No. 09/102,602; U.S. Patent No. 6,380,394 B1 issued Apr. 30, 2002.
53. Epothilone Analogs, K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, Serial No. 09/319,885; U.S. Patent No. 6,660,758 B1 issued Dec. 9, 2003.
54. Epothilone Analogs, K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, Serial No. 10/732,698; U.S. Patent No. 7,173,137 issued Feb. 6, 2007.
55. Epothilone Derivatives and Their Synthesis and Use, K.C. Nicolaou, N.P. King, M.R. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, Serial No. 09/720,070; U.S. Patent No. 6,531,497 B1 issued Mar. 11, 2003.
56. Epothilone Derivatives and Their Synthesis and Use, K.C. Nicolaou, N.P. King, M.R. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, Int. Patent Appl. PCT/EP99/04287; Int. Publ. No. WO99/67252, published Dec. 29, 1999.
57. Epothilone Derivatives and Their Synthesis and Use, K.C. Nicolaou, N.P. King, M.R. Finlay, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, D. Vourloumis, H. Vallberg, N. Winssinger, Z. Yang, PCT/EP97/07011, Int. Publ. No. WO 98/25929, Jun. 18, 1998.
58. Epothilone Derivatives and Their Synthesis and Use, K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, Serial No. 10/386,999; U.S. Patent No. 7,579,366 B2, issued Aug. 25, 2009
59. Analogs of Sarcodictyin and Eleutherobin Analogs, K.C. Nicolaou, F. Van Delft, S. Hosokawa, S. Kim, T. Li, T. Ohshima, J. Pfefferkorn, D. Vourloumis, J.-Y. Xu, N. Winssinger, Serial No. 09/145,376; U.S. Patent No. 5,965,718 issued Oct. 12, 1999.
60. Inhibitors of NADH:Ubiquinone Oxidoreductase, K.C. Nicolaou, J. Pfefferkorn, G.-Q. Cao, A. J. Roecker, Serial No. 10/363,181, U.S. Patent No. 7,410,998 B2, issued Aug. 12, 2008.
61. Cyclopropyl and Cyclobutyl Epothilone Analogs, K.C. Nicolaou, K. Namoto, A. Ritzén, M. Shoji, T. Ulven, K.-H. Altmann, Serial No. 10/227,073; U.S. Patent No. 7,358,266 B2 issued Apr. 15, 2008.
62. Synthesis of Non-Symmetrical Sulfamides Using Burgess-Type Reagents, K.C. Nicolaou, D. Longbottom, S.A. Snyder, X. Huang, Serial No.10/685,658; U.S. Patent No. 7,015,321 B2 issued March 21, 2006.
63. Analogs of Epothilones, K.C. Nicolaou, K. Namoto, A. Ritzén, Serial No. 10/634,537; U.S. Patent No. 7,169,930 B2 issued Jan. 30, 2007.
64. Epothilone Analogs, K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R. Finlay, Serial No. 10/732,698; U.S. Patent No. 7,173,137 B2 issued Feb. 6, 2007.
65. HIF-1 Inhibitors, E. Van Meir, C. Tan, K.C. Nicolaou, A. J. Roecker, Serial No. 10/550,286; U.S. Patent No. 7,652,033 issued Jan. 26, 2010.
66. Chemical Synthesis of a Highly Potent Epothilone, K.C. Nicolaou, B. Pratt, S. Arseniyadis, Serial No. 12/092,038; U.S. Patent No. 8,003,801 issued Aug. 23, 2011.
67. HIF-1 Inhibitors, E. Van Meir, K.C. Nicolaou, Serial No. 11/977,809; U.S. Patent No. 8,071,795 B2 issued Dec. 6, 2011.
