Daniel A. Bachovchin

Development and Application of Activity-Based Proteomic Platforms for Inhibitor Discovery

Advisor: Benjamin F. Cravatt, Professor and Chair, Department of Chemical Physiology

Michael James Barnes

Forward Genetic and Cellular Studies of Intestinal Immune Regulation: the Roles of Carma1, Interleukin-10 and Gimap5

Academic Advisor: Ian A. Wilson, Professor, Department of Molecular Biology
Advisors: Bruce Alan Beutler, Professor and Chair, Department of Genetics; Fiona Powrie, Professor, Sir William Dunn School of Pathology, University of Oxford

Steven David Brown

Bacteriophage Qβ: A Versatile Platform for Nanoengineering

Advisor: M. G. Finn, Professor, Department of Chemistry

Russell Gerald Burge

Biochemical and Structural Characterization of Non-Specific RNA-Binding Zinc Finger Proteins

Advisor: Peter E. Wright, Professor and Chair, Department of Molecular Biology

Stuart M. Cahalan

Genetic and Chemical Approaches to Understanding S1P1 Receptor Physiology and Pathology

Advisor: Hugh Rosen, Professor, Department of Chemical Physiology

Yeeting Esther Chong

Functional Studies of Aminoacyl-tRNA Synthetases in Translation and Beyond

Advisor: Paul Schimmel, Professor, Department of Molecular Biology

Chung-Han Chu

Progress toward Single-Molecule Nanopore DNA Sequencing

Advisor: M. Reza Ghadiri, Professor, Department of Chemistry

Elizabeth Kathleen Culyba

Enhanced Aromatic Sequons in Turns Reliably Stabilize N-linked Glycoprotein Native States

Advisor: Jeffery W. Kelly, Professor and Chair, Department of Molecular and Experimental Medicine

Kelly A. Flanagan

Pheromone-mediated Sexual Maturation: When Puberty begins in the Nose

Advisor: Lisa Stowers, Associate Professor, Department of Cell Biology

Brian M. Frezza

Orchestration of Molecular Information through Higher Order Chemical Recognition

Advisor: M. Reza Ghadiri, Professor, Department of Chemistry

Christine Fang Gelin

Part I. Total Synthesis of Artochamins H, I, J, and K
Part II. Synthesis of the QRSTU Domain of Maitotoxin and its 85-epi-and 86-epi-Diastereoisomers

Advisor: K. C. Nicolaou, Professor and Chair, Department of Chemistry

Sulagna Ghosh

Wiring Smell in the Olfactory Cortex: Insights from Single Neuron Tracing Studies of Defined Projection Neurons

Advisor: Kristin Baldwin, Assistant Professor, Department of Cell Biology

Jing Guo

Directed Evolution and Engineering of Zinc Finger Nucleases for Targeted Genome Modification

Advisor: Carlos F. Barbas III, Professor, Department of Chemistry

Peter G. Hawkins

RNA-mediated Transcriptional Regulation in Human Cells: Mechanistic Insights and Novel Effector Molecules

Advisor: Kevin Morris, Assistant Professor, Department of Molecular and Experimental Medicine

Graham T. Johnson

Automated Modeling and Visualization of Mesoscale Cellular Environments

Advisor: Arthur Olson, Professor, Department of Molecular Biology

Daisuke Kato

Asymmetric Total Synthesis of Vindorosine, Vindoline, and Key Vinblastine Analogues

Advisor: Dale L. Boger, Professor, Department of Chemistry

Sherman Ku

Modelling Friedreich's Ataxia Using Human Inducted Pluripotent Stem Cells

Advisor: Joel Gottesfeld, Professor, Department of Molecular Biology

Sen Wai Kwok

Synthetic Applications and Mechanistic Studies of Rhodium(II)-Catalyzed Transformations of 1,2,3-Triazoles

Advisors: Valery Fokin, Associate Professor, Department of Chemistry and K. Barry Sharpless, Professor, Department of Chemistry

Jolene L. Lau

Probing the Interior of Bacteriophage Qbeta Virus-like Particles

Advisor: M. G. Finn, Professor, Department of Chemistry

Pick-Wei Lau

Molecular Mechanism of Small RNA Biogenesis Revealed by the Structural Architecture of Human Dicer

Advisors: Bridget Carragher, Associate Professor, Department of Cell Biology; Ian J. MacRae, Assistant Professor, Department of Molecular Biology

Weiwei Li

A Functional Proteomic Strategy to Discover Inhibitors for Uncharacterized Serine Hydrolases

Advisor: Benjamin F. Cravatt, Ph.D. Professor and Chair, Department of Chemical Physiology

Yee Hwee Lim

I. Total Syntheses of Bisanthraquinones through Cascade Reactions
II. 18F-radiochemistry to Advance Cancer Imaging

Advisor: Véronique Gouverneur, Professor, Department of Chemistry, University of Oxford

David W. Lin

Part I. Oxidative Coupling of Enolates and Pyrroles
Part II. Synthesis-Guided Structural Revision of the Sarcodonin, Sarcoviolin and Hydnellin Natural Product Family

Advisor: Phil S. Baran, Professor, Department of Chemistry

Timothy Russell Newhouse

Total Syntheses of Psychotrimine and Kapakahines B and F

Advisor: Phil S. Baran, Professor, Department of Chemistry

Christine Nguyen

Synthetic Studies toward Scytophycin C

Advisor: William R. Roush, Professor, Department of Chemistry

Derrick Sek Tong Ong

Proteostasis Regulators to Ameliorate Loss-of-function Diseases

Advisor: Jeffery W. Kelly, Professor and Chair, Department of Molecular and Experimental Medicine

Paresma R. Patel

Intramolecular Cycloaddition Reactions of Cyclopropenone Ketals

Advisor: Dale L. Boger, Professor, Department of Chemistry

Tucker C. Roberts

Synthesis and Derivatization of the Arylomycin Family of Natural Product Antibiotics

Advisor: Floyd E. Romesberg, Associate Professor, Department of Chemistry

Sophie Rozenzhak

DNA Repair and Checkpoint Factors Protect the Genome During DNA Replication

Advisor: Paul R. Russell, Profressor, Department of Molecular Biology

Peter Andrew Smith

Latent Antibiotics and the Potential of the Arylomycin Class of Natural Products

Advisor: Floyd E. Romesberg, Associate Professor, Department of Chemistry

Sevil Aydanova Sofueva

Cellular Responses to DNA Double-strand Breaks and Impaired Replication fork Progression in the Fission Yeast Schizosaccharomyces pombe

Advisor: Paul R. Russell, Professor, Department of Molecular Biology

Jennifer Brooke Treweek

Immunological Therapeutics for Drugs of Abuse: from Self-vaccination to Passive Vaccination

Advisor: Kim D. Janda, Professor, Department of Chemistry

Laura M. Walker

Broadly Neutralizing Antibodies and Broadly Neutralizing Sera: Insights into HIV-1 Vaccine Design

Advisor: Dennis R. Burton, Professor, Department of Immunology and Microbial Science

Donghui Wang

Practical C-H Activation/C-C Bond-Forming Reactions Using O2 as the Oxidant and their Applications in Total Synthesis

Advisor: Jin-Quan Yu, Professor, Department of Chemistry

Jianhua Wang

Total Synthesis of Platensimycin, Carbaplatensimycin and Sporolide B

Advisor: K. C. Nicolaou, Professor and Chair, Department of Chemistry

Stuart W. Webb

Functional Characterization of Protocadherin-15 Isoforms in Mechanosensory Hair Cells

Advisor: Ulrich Mueller, Professor, Department of Cell Biology

SusAnn M. Winbush

I. Formal Synthesis of (-)-Spinosyn A Aglycone: Examination of Structural Features that Govern the Stereoselectivity of the Key Transannular Diels-Alder Reaction
II. Development of a Cross-Metathesis Allylboration Sequence for the Enantioselective Synthesis of (Z)-1,2-ANTI-2,5-ANTI-1,2,5-Triols

Advisor: William R. Roush, Professor, Department of Chemistry

Fei Xu

Exploring the Structural Basis for GPCR Signal Transduction

Advisor: Raymond C. Stevens, Professor, Department of Molecular Biology