Scientific Report 2007

Scripps Florida

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Translational Research Institute

Pharmacology Services

L.H. Smith, A. Pachori, S. Khan, M. Lopez, D. Zadory

We provide comprehensive pharmacology services and expertise in support of drug discovery efforts for Scripps Research at both the Florida and California sites. We use cutting-edge technology and established models of disease to validate and confirm the efficacy of new chemical compounds and to assess the druglike characteristics of the compounds. Our disease models include tumor xenografts, hypertension, angiogenesis, hyperlipidemia, obesity induced via diet or genetic manipulation, diabetes, and Parkinson's disease. Studies of this kind require expertise in many scientific disciplines. Thus, we work with researchers in Medicinal Chemistry, Drug Metabolism and Pharmacokinetics, and Cell Biology and the leaders of each project team to move drug discovery projects from the test tube to in vivo models and, ultimately, to clinical trials.