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News and Publications
TSRI Scientific Report 1998-1999
General Clinical Research Center
E. Beutler, F.V. Chisari, B.L. Zuraw, D.R. Salomon, J.A. Koziol, S. Mirkis, E.E. Jensen, E.A. Bieger, K.H. Cox
Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 25th year of continuous operation. Financed by a $14 million grant from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 75 such centers in the United States that is not affiliated with a university or a medical school. The Center aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, elucidate pathogenetic mechanisms of disease, and evaluate new modes of patient management.
The GCRC provides inpatient and outpatient environments in which investigators conduct studies in humans; the protocols followed are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in the Scripps Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of TSRI; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery.
In addition, the GCRC operates a computer center with a Unix workstation environment for the management of clinical data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.
Last year, the GCRC provided these services for about 5000 outpatient visits, processed about 6700 specimens, and supported 41 computer-based research protocols from TSRI and the Scripps Clinic Medical Group. Fifty-eight patient-related research protocols were carried out in the GCRC; the titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. A total of 97 investigators made use of the GCRC's facilities, and 90 peer-reviewed articles and abstracts resulting from GCRC-assisted research were published last year.
| PRINCIPAL INVESTIGATOR | PROTOCOL TITLE |
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| Roger Beachy, PhD | Characterization of Food-Allergic Patients and Food Allergens to Create a Hypoallergenic Plant |
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| Ernest Beutler, MD | Normal Blood-Drawing for TSRI Labs |
| Ernest Beutler, MD | Studies and Enzyme Replacement Therapy in Gaucher Disease |
| Dennis R. Burton, PhD | Human Antibodies to Infectious Agents |
| Francis Chisari, MD | Immunobiology and Pathogenesis of Hepatitis |
| Clifford Colwell, MD | Comparison of DVT-Prevention Therapies Following Joint Replacement |
| Denis Darko, MD | Fatigue and Sleep Abnormalities in HIV Infection: Identification of Therapies |
| Arthur Dawson, MD | Hypoxemia and Pulmonary Hypertension in Gaucher Disease |
| Cindy Ehlers, PhD | EEG Markers of Alcoholism Risk |
| Cindy Ehlers, PhD | Fetal Alcohol Syndrome Studies |
| Cindy Ehlers, PhD | Response to Ethanol in Asian-, African-, and Native Americans |
| Lawrence Kline, DO | DPAP for Obstructive Sleep Apnea |
| Thomas Kunicki, PhD | Relationship Between Membrane Density of a2ß1 Integrin and CAD |
| John McHutchison, MD | Intron A and Alferon-N for Hepatitis C |
| Robert McMillan, MD | Studies in Idiopathic Thrombocytopenic Purpura (ITP) |
| Lindsey Miles, PhD | Prothrombotic Effects in Lipoprotein(a) |
| Merrill Mitler, PhD | Narcolepsy: Human Genetics and HLA Correlates |
| Donald Mosier, MD, PhD | Adoptive Immune Therapy in the hu-PBL-SCID Model |
| Donald Mosier, MD, PhD | T-Cell Changes in HIV-1 Infection |
| Paul Pockros, MD | Studies of Interferon in Hepatitis B and Hepatitis C |
| Vance Rodgers, MD | 2-CdA for Crohn's Disease and Ulcerative Colitis |
| Deborah Schiff, MD | Recombinant IFN-g in Normal Subjects |
| Jack Sipe, MD | Cladribine (2-CdA) Treatment of Multiple Sclerosis |
| Donald Stevenson, MD | Analgesic Desensitization in Aspirin-Sensitive Asthma |
| Bruce Torbett, PhD | Disruption of Human Hematopoiesis by HIV-1 |
| Katharine Woessner, MD | Gene Expression of Airway Epithelial Cells in Allergic Rhinitis |
| John Yu, MD, PhD | Effects of New Cytokines on Hematopoietic Stem/Progenitor Cells |
| Bruce Zuraw, MD | Angioedema and Hageman Factor |
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