Scientific Report 2008
The Harold L. Dorris Neurological Research Institute
and major depression affect many millions of people worldwide. Treatment of these
psychiatric diseases requires an understanding of their underpinnings, and
this need is the driving force for research at the Harold L. Dorris Neurological
Research Institute. Founded in 1999 with a $10 million long-term commitment by Ms.
Helen Dorris through the Harold L. Dorris Foundation, named in her brother's
honor, the institute has attracted an international cadre of scientists from France,
Switzerland, Sweden, Mexico, Italy, Spain, and Hungary in disciplines such as neurology,
immunology, chemistry, molecular biology, and endocrinology to study neurological
Harold L. Dorris Neurological Institute also funds the Helen Dorris Fellow in Schizophrenia,
a named fellowship position for a postdoctoral researcher to study aspects of schizophrenia
and depression from molecular and cellular neurobiological perspectives. The current
fellow is Olivia Osborn from Oxford University in England. The visiting professors
at the institute in 2007 were the well-known electrophysiologist and member of the
French Academy of Sciences, Henri Korn from the Pasteur Institute in Paris, France;
noted pharmacologist and member of the Royal Swedish Academy of Sciences, Lars Terenius
from the Karolinska Institutet in Stockholm, Sweden; and molecular immunologist
Hermann Gram from Novartis Global Research, Basel, Switzerland.
The major lines of research carried out
by in vitro and in vivo techniques are on the effects of galanin on depression and
neurogenesis and on IL-1 signaling in the nervous system and its involvement in
stress, depression, and febrile responses.