Scientific Report 2008

Department of Genetics

Chairman's Overview

Staff

Bruce Beutler, M.D.
Professor and Chairman

Staff Scientists

Xin Du, Ph.D.

Yu Xia, Ph.D.

Research Associates

Carrie Arnold, Ph.D.

Michael Berger, Ph.D.

Amanda Blasius, Ph.D.

Katharina Brandl, Ph.D.

Celine Eidenschenk, Ph.D.

Philippe Krebs, Ph.D.

Xiaohong Li, Ph.D.

Lei Sun, Ph.D.

Sungyong Won, Ph.D.

Nengming Xiao, Ph.D.

Scientific Associate

Kevin Khovananth

Technical Writers

Eva Marie Y. Moresco, Ph.D.

Nora Smart, Ph.D.

Cells stained for the endoplasmic reticulum protein UNC93B tagged with green fluorescent protein and a marker of lysosomes (Lyso-tracker Red). Image is from a study on the function of UNC93B, a protein discovered because Toll-like receptors 3, 7, and 9 require it for signaling. UNC93B escorts the receptors from the endoplasmic reticulum to the lysosomes, where the receptors act to sense nucleic acids. Animals and humans lacking UNC93B are immunocompromised in several ways; in particular, they cannot cope with herpesvirus infections such as those caused by mouse cytomegalovirus or human herpes simplex virus. Work done in the laboratory of Bruce Beutler, M.D., professor. Reprinted from Tabeta, K., et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol. 7:156, 2006.

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