Scientific Report 2008
Department of Genetics
Bruce Beutler, M.D.
Professor and Chairman
Xin Du, Ph.D.
Yu Xia, Ph.D.
Carrie Arnold, Ph.D.
Michael Berger, Ph.D.
Amanda Blasius, Ph.D.
Katharina Brandl, Ph.D.
Celine Eidenschenk, Ph.D.
Philippe Krebs, Ph.D.
Xiaohong Li, Ph.D.
Lei Sun, Ph.D.
Sungyong Won, Ph.D.
Nengming Xiao, Ph.D.
Eva Marie Y. Moresco, Ph.D.
Nora Smart, Ph.D.
for the endoplasmic reticulum protein UNC93B tagged with green fluorescent protein
and a marker of lysosomes (Lyso-tracker Red). Image is from a study on the function
of UNC93B, a protein discovered because Toll-like receptors 3, 7, and 9 require
it for signaling. UNC93B escorts the receptors from the endoplasmic reticulum to
the lysosomes, where the receptors act to sense nucleic acids. Animals and humans
lacking UNC93B are immunocompromised in several ways; in particular, they cannot
cope with herpesvirus infections such as those caused by mouse cytomegalovirus or
human herpes simplex virus. Work done in the laboratory of Bruce Beutler, M.D.,
professor. Reprinted from Tabeta, K., et al. The Unc93b1 mutation 3d disrupts exogenous
antigen presentation and signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol.
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