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Scientific Report 2007


The Skaggs Institute for Chemical Biology




Director's Overview

Members


Julius Rebek, Jr., Ph.D.*
Professor and Director

Carlos F. Barbas III, Ph.D.**
Professor
Janet and W. Keith Kellogg II Chair in Molecular Biology

Tamas Bartfai, Ph.D.***
Professor
Chairman, Molecular and Integrative Neurosciences Department, Scripps Research
Director, Harold L. Dorris Neurological Research Institute

Ernest Beutler, M.D.****
Professor
Chairman, Department of Molecular and Experimental Medicine, Scripps Research

Dale L. Boger, Ph.D.*
Richard and Alice Cramer Professor of Chemistry

Geoffrey Chang, Ph.D.**
Associate Professor

Benjamin F. Cravatt, Ph.D.*****
Professor
Director, Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute

Gerald M. Edelman, M.D., Ph.D.
Professor
Chairman, Department of Neurobiology, Scripps Research

Albert Eschenmoser, Ph.D.*
Professor

Martha J. Fedor, Ph.D.**
Associate Professor

M.G. Finn, Ph.D.*
Associate Professor

Elizabeth D. Getzoff, Ph.D.††
Professor

M. Reza Ghadiri, Ph.D.*
Professor

Kim D. Janda, Ph.D.*
Professor
Ely R. Callaway, Jr., Chair in Chemistry
Director, The Worm Institute for Research and Medicine

Gerald F. Joyce, M.D., Ph.D.†††
Professor
Dean, Faculty

Ehud Keinan, Ph.D.**
Adjunct Professor

Jeffery W. Kelly, Ph.D.*
Lita Annenberg Hazen Professor of Chemistry
Dean, Graduate and Postgraduate Studies

Richard A. Lerner, M.D.†††
President, Scripps Research
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Stephen P. Mayfield, Ph.D.††††
Professor
Associate Dean, Kellogg School of Science and Technology

Ullrich Müller††††
Professor

K.C. Nicolaou, Ph.D.*
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry
Chairman, Department of Chemistry, Scripps Research

Paul R. Schimmel, Ph.D.†††
Ernest and Jean Hahn Professor and Chair in Molecular Biology and Chemistry

Peter Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
W.M. Keck Professor of Chemistry

Lisa T. Stowers, Ph.D.††††
Assistant Professor

John A. Tainer, Ph.D.**
Professor

Paul Wentworth, Jr.*
Professor

James R. Williamson, Ph.D.†††
Professor
Associate Dean, Kellogg School of Science and Technology

Ian A. Wilson, D.Phil.**
Professor

Chi-Huey Wong, Ph.D.*
Ernest W. Hahn Professor and Chair in Chemistry

Peter E. Wright, Ph.D.**
Professor
Cecil H. and Ida M. Green Investigator in Biomedical Research
Chairman, Department of Molecular Biology, Scripps Research

Kurt Wüthrich, Ph.D.†††
Cecil H. and Ida M. Green Professor of Structural Biology


Research Associates


Dariush Ajami, Ph.D.

Elizabeth Barrett, Ph.D.

Naran Gombosuren, Ph.D.

Richard J. Hooley, Ph.D.

Junli Hou, Ph.D.

Tetsuo Iwasawa, Ph.D.

Enrique Mann, Ph.D.

Lionel Moisan, Ph.D.

Severin Odermatt, Ph.D.

Fernando R. Pinacho Crisotomo, Ph.D.

Per Restorp, Ph.D.

Michael Schramm, Ph.D.

Siddhartha Shenoy, Ph.D.

Craig Turner



* Joint appointment in the Department of Chemistry
** Joint appointment in the Department of Molecular Biology
**** Joint appointment in the Department of Molecular and Experimental Medicine
***** Joint appointments in the Departments of Cell Biology
and Chemistry
Joint appointment in the Department of Neurobiology
†† Joint appointments in the Departments of Molecular Biology and Immunology
††† Joint appointments in the Departments of Chemistry and Molecular Biology
†††† Joint appointment in the Department of Cell Biology
††††† Research associates in the laboratories of members other than Dr. Rebek are included in the lists of the respective departments in which the associates hold joint appointments

 


Reactive intermediates can be stabilized and isolated in a synthetic receptor. Small amines are bound in a cup-shaped receptor and positioned near an aldehyde. Reaction occurs to give a reactive hemiaminal featuring a new asymmetric center (shown in gold). Graphics obtained with software by AVS, Inc., by Michael Pique, director, Computer Graphics Development, and Michel Sanner, Ph.D., associate professor, Department of Molecular Biology, Scripps Research.



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