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Scientific Report 2007


Molecular and Integrative Neurosciences





Chairman's Overview

Staff


Tamas Bartfai, Ph.D.*
Chairman and Professor
Director, Harold L. Dorris Neurological Research Institute

Serge Ahmed, Ph.D.
Adjunct Assistant Professor

Etienne Baulieu, Ph.D.
Adjunct Professor

Floyd Bloom, M.D.
Professor Emeritus
Executive Director, Science Communication

Jason Botten, Ph.D.
Assistant Professor

Benjamin Boutrel, Ph.D.
Professor Emeritus

Karen T. Britton, M.D., Ph.D.
Adjunct Associate Professor

Michael Buchmeier, Ph.D.
Professor

Iain L. Campbell, Ph.D.
Adjunct Professor

Kathleen Cashman, Ph.D.
Professor Emeritus

Zhen Chai, Ph.D.
Adjunct Assistant Professor

Jerold Chun, M.D., Ph.D.
Adjunct Professor

Bruno Conti, Ph.D.
Associate Professor

Jose Criado, Ph.D.
Adjunct Assistant Professor

Juan Carlos de la Torre, Ph.D.
Associate Professor

Cindy L. Ehlers, Ph.D.
Associate Professor

Howard S. Fox, M.D., Ph.D.
Associate Professor

Hermann H. Gram, Ph.D.
Adjunct Associate Professor

Donna L. Gruol, Ph.D.
Associate Professor

Steven J. Henriksen, Ph.D.
Adjunct Professor

Paul L. Herrling, Ph.D.
Adjunct Professor

Tomas Hokfelt, M.D., Ph.D.
Adjunct Professor

Danny Hoyer, Ph.D.
Adjunct Professor

Koki Inoue, Ph.D.
Adjunct Associate Professor

Harvey Karten, M.D.
Adjunct Professor

Henri Korn, M.D., Ph.D.
Adjunct Professor

Thomas Krucker, Ph.D.
Adjunct Assistant Professor

Stefan Kunz, Ph.D.
Assistant Professor

Cary Lai, Ph.D.
Associate Professor

Ulo Langel, Ph.D.
Adjunct Professor

Michel Le Moal, M.D., Ph.D.
Adjunct Professor

Xiaoying Lu, Ph.D.
Assistant Professor

Jan O. Lundstrom, Ph.D.
Adjunct Professor

Athina Markou, Ph.D.
Adjunct Professor

Dorian McGavern, Ph.D.
Associate Professor

Madis Metsis, Ph.D.
Adjunct Associate Professor

Benjamin Neuman, Ph.D.
Assistant Professor

Michael B.A. Oldstone, M.D.
Professor

Shirley M. Otis, M.D.
Adjunct Professor

Tommy Phillips, Ph.D.
Adjunct Assistant Professor

John Polich, Ph.D.
Associate Professor

Luigi Pulvirenti, M.D.
Adjunct Associate Professor

Teresa Reyes, Ph.D.
Adjunct Assistant Professor

Catherine Rivier, Ph.D.
Adjunct Professor

Amanda Roberts, Ph.D.
Assistant Professor

Michael G. Rosenfeld, M.D.
Adjunct Professor

Pietro P. Sanna, M.D.
Associate Professor

Paul Schweitzer, Ph.D.
Associate Professor

George R. Siggins, Ph.D.
Professor

Iustin Tabarean, Ph.D.
Assistant Professor

Antoine Tabarin, Ph.D.
Adjunct Associate Professor

Lars Terenius, Ph.D.
Adjunct Professor

Claes Wahlestedt, M.D., Ph.D.
Adjunct Professor

Tammy Wall, Ph.D.
Adjunct Associate Professor

Friedbert Weiss, Ph.D.
Professor

J. Lindsay Whitton, M.B., Ch.B., Ph.D.
Professor


Staff Scientists


David Brooks, Ph.D.

Walter Francesconi, Ph.D.

David Gilder, M.D.

Bumsuk Hahm, Ph.D.

Salvador Huitrón-Reséndiz, Ph.D.

M. Cecilia Marcondes, Ph.D.

Remi Martin-Fardon, Ph.D

Tom Nelson, Ph.D.

Manuel Sánchez-Alavaz, M.D., Ph.D.

Mitra Rebek, Ph.D.

Brendan Walker, Ph.D.

Science Associates


Caroline Lanigan, Ph.D.

Hanna Lewicki

John Light

Sam Madamba

Antoinette Tishon

Research Associates


Mehrdad Alirezaei, Ph.D.

Michal Bajo, M.D., Ph.D.Hilda Bajova, D.V.M.

Fulvia Berton, Ph.D.

Lucy Breakwell, Ph.D.

Vez Repunte Canonigo, Ph.D.

Althea Capul, Ph.D.

Roberto Cervera, Ph.D.

Zhifeng Chen, Ph.D.

Christopher Cornell, Ph.D.

Cromwell Cornillez-Ty, Ph.D.

Stephen J. Crocker, Ph.D.

Sebastien Emonet, Ph.D.

Ralph Feuer, Ph.D.

Lucile Garidou, Ph.D.

Kazuki Hagihara, Ph.D.

Silvia Kang, Ph.D.

Cristopher Kemball, Ph.D.

Izabella Klein, Ph.D.

Paul Krogstad, M.D.

Henning Lauterbach, Ph.D.

Andrew Lee, Ph.D.

Li Ying Liou, Ph.D.

Fei Lu, Ph.D.

Kayo Mitsukawa, Ph.D.

Olivia Osborn, Ph.D.

Covadonga Paneda, Ph.D.

Neil Paterson, M.D.

Gurudutt Pendyala, Ph.D.

Jerry Pinghwa Pian, Ph.D.

Jilla Sabeti, Ph.D.Ana Sanchez, Ph.D.

Matt Trifilo, Ph.D.

Jason Whitmire, Ph.D.

Ge Ying, Ph.D.

Elina Zuniga, Ph.D.

Visiting Investigators


Hedieh Badie, Ph.D.
Genomics Institute of the Novartis Research Foundation
San Diego, California

Persephone Borrow, Ph.D.
Edward Jenner Institute for Vaccine Research
Comptom, England

Roberto Ciccocioppo, Ph.D.
University of Camerino
Camerino, Italy

Urs Christen, Ph.D.
La Jolla Institute for Allergy and Immunology
La Jolla, California

Jean E. Gairin, Ph.D.
CNRS
Toulouse, France

Karine Guillem, Ph.D.
University of Pennsylvania
Philadelphia, Pennsylvania

Katsuro Hagiwara, Ph.D.
Rakuno Gakuen University
Hokkaido, Japan

Dirk Homann, M.D., Ph.D.
University of Colorado Health Sciences Center
Denver, Colorado

Shinchi Iwasaki, M.D., Ph.D.
Osaka City University Medical School
Osaka, Japan

Rolf Kiessling, Ph.D.
Karolinska Institutet
Stockholm, Sweden

Denise Naniche, Ph.D., M.P.H.
Universitat de Barcelona
Barcelona, Spain

Noemi Sevilla, Ph.D.
Universidad Autonoma de Madrid
Madrid, Spain

Christina Spiropoulou, Ph.D.
Centers for Disease Control and Prevention
Atlanta, Georgia



* Joint appointment in the Skaggs Institute for Chemical Biology

 


Viral meningitis in real time. Meningitis is a disease in humans caused by a variety of viruses and bacteria. During the disease, the lining of the brain (or meninges) becomes inundated with inflammatory cells, which induce seizures and profound neurologic dysfunction. In order to gain novel insights into the dynamics of meningitis, an approach was established to visualize the disease in real time through
a thinned skull in virus-infected rodents. The image is
a 3-dimensional projection of a movie frame captured by using a 2-photon microscope during the peak of meningitis induced by lymphocytic choriomeningitis virus (LCMV). The area of the projection, just below the surface of the skull (blue), shows profound infiltration of the meningeal space by LCMV-specific cytotoxic lymphocytes (green). The lymphocytes are absolutely required for the seizures that occur during meningitis and induce considerable leakage (or breakdown) in the dense network of meningeal vasculature (red). Work done in the laboratory of Dorian McGavern, Ph.D., associate professor.



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