Scientific Report 2007

Molecular and Experimental Medicine

Chairman's Overview

Staff

Ernest Beutler, M.D.*
Chairman and Professor
Head, Division of Hematology and Genetics

Masahiro Aoki, M.D., Ph.D.
Adjunct Assistant Professor

Hiroshi Asahara, M.D., Ph.D.
Assistant Professor of Molecular Medicine

Bonno N. Bouma, Ph.D.
Adjunct Professor

William D. Bugbee, M.D.
Adjunct Associate Professor

Joel N. Buxbaum, M.D.
Professor
Head, Division of Research Rheumatology

Dennis A. Carson, M.D.
Adjunct Professor

Sergio D. Catz, Ph.D.
Assistant Professor

Francis V. Chisari, M.D.
Professor
Head, Division of Experimental Pathology

Clifford W. Colwell, Jr., M.D.
Adjunct Professor

Laura M. Crisa, M.D.
Assistant Professor of Molecular Medicine

Arthur D. Dawson, M.D.
Adjunct Professor

Albert B. Deisseroth, M.D., Ph.D.
Adjunct Professor

Gregory J. del Zoppo, M.D.**
Associate Professor of Experimental Medicine

Thomas F. Deuel, M.D.
Professor
Head, Division of Molecular Oncology

Darryl D'Lima, M.D.
Assistant Professor

Darlene J. Elias, M.D.
Adjunct Associate Professor

Brunhilde Felding-Habermann, Ph.D.
Associate Professor

Kelly A. Frazer, Ph.D.
Associate Professor of Translational Genomics

Mitchell H. Friedlaender, M.D.
Adjunct Professor

Jeffrey S. Friedman, M.D., Ph.D.
Assistant Professor

Theodore Friedmann, M.D.
Adjunct Professor

Andrew J. Gale, Ph.D.
Assistant Professor

Roberta A. Gottlieb, M.D.***
Associate Professor
San Diego State University
San Diego, California

John H. Griffin, Ph.D.**
Professor
Head, Division of Translational Vascular Medicine Research

Andras Gruber, M.D.
Adjunct Assistant Professor

Luca G. Guidotti, D.V.M., Ph.D.
Associate Professor

Asa B. Gustafsson, Ph.D.
Adjunct Assistant Professor

Anne M. Hanneken, M.D.
Associate Professor

Mary J. Heeb, Ph.D.**
Associate Professor

James A. Hoch, Ph.D.
Professor
Head, Division of Cellular Biology

Frank M. Huennekens, Ph.D.
Professor Emeritus

Brian F. Issell, M.D.
Adjunct Professor

Shaun Phillip Jackson, Ph.D.
Adjunct Associate Professor

Eric F. Johnson, Ph.D.
Professor
Acting Head, Division of Biochemistry

Thomas J. Kipps, M.D., Ph.D.
Adjunct Professor

Lawrence E. Kline, D.O.
Adjunct Associate Professor

James A. Koziol, Ph.D.
Professor
Head, Division of Biomathematics

Daniel F. Kripke, M.D.
Adjunct Professor

Thomas J. Kunicki, Ph.D.**
Associate Professor

Pauline L. Lee, Ph.D.
Associate Professor of Molecular Medicine

Stuart A. Lipton, M.D., Ph.D.
Adjunct Professor

Martin Lotz, M.D.
Professor
Head, Division of Arthritis Research

Christopher Lee Marsh, M.D.
Adjunct Associate Professor

David A. Matthews, Ph.D.
Adjunct Professor

Robert McMillan, M.D.
Professor Emeritus

William E. Miller, M.D.
Adjunct Assistant Professor

Richard Milner, M.D., Ph.D.
Assistant Professor

Kevin V. Morris, Ph.D.
Assistant Professor

Sarah Shaw Murray, Ph.D.
Assistant Professor of Translational Genomics

Jorge J. Nieva, M.D.***
Assistant Professor
Billings Clinic
Billings, Montana

Marta Perego, Ph.D.
Associate Professor

Paul J. Pockros, M.D.
Adjunct Assistant Professor

K. Michael Pollard, Ph.D.
Associate Professor of Molecular Medicine

Giuseppe Remuzzi, M.D.
Adjunct Professor

Zaverio M. Ruggeri, M.D.**
Professor
Head, Division of Blood Cell and Vascular Biology

Enrique Saldivar, M.D., Ph.D.
Adjunct Assistant Professor

Daniel R. Salomon, M.D.
Associate Professor

Nicholas J. Schork, Ph.D.
Professor

Alessandro Sette, Ph.D.
Adjunct Professor

Farhad F. Shadan, M.D., Ph.D.
Adjunct Assistant Professor

Sanford J. Shattil, M.D.
Adjunct Professor

Alexander R. Shikhman, M.D., Ph.D.
Adjunct Assistant Professor

Inmaculada Silos-Santiago, M.D., Ph.D.
Adjunct Associate Professor

Gregg J. Silverman, M.D.
Adjunct Professor

Ronald A. Simon, M.D.
Adjunct Professor

Jack C. Sipe, M.D.
Associate Professor

Donald D. Stevenson, M.D.
Adjunct Professor

Eng M. Tan, M.D.
Professor Emeritus

Eric J. Topol, M.D.
Professor of Translational Genomics

Bruce E. Torbett, Ph.D.
Associate Professor

Susan L. Uprichard, Ph.D.***
Assistant Professor
University of Illinois
Chicago, Illinois

Kottayil I. Varughese, Ph.D.***
Associate Professor
University of Arkansas
Little Rock, Arkansas

Peter K. Vogt, Ph.D.
Professor
Head, Division of Oncovirology

Matthias G. von Herrath, M.D.
Adjunct Associate Professor

Jill M. Waalen, M.D.
Assistant Professor

Xiaohua Wu, Ph.D.
Assistant Professor

Takao Yagi, Ph.D.
Associate Professor

Dong-Er Zhang, Ph.D.
Professor

Staff Scientists

Andreas G. Bader, Ph.D.***
Asuragen, Inc.
Austin, Texas

Joseph R. Biggs, Ph.D.

Stephanie Cherqui, Ph.D.

Mei-Hui Hsu, Ph.D.

Chengqun Huang, M.D., Ph.D.***
San Diego State University
San Diego, California

Jennifer L. Johnson, Ph.D.

Sunil M. Kurian, Ph.D.

Patrizia Marchese, Ph.D.

Tsaiwei Olee, Ph.D.

Brian Savage, Ph.D.

Uzen Savas, Ph.D.

Rachel D. Schrier, Ph.D.

Stefan Wieland, Ph.D.

Akemi Yagi, Ph.D.

Ming Yan, Ph.D.

Senior Research Associates

Hiroshi Deguchi, M.D., Ph.D.

Yuichi Kamikubo, Ph.D.

Joseph S. Krueger, Ph.D.

Laurent O. Mosnier, Ph.D.

Deirdre M. O'Sullivan, Ph.D.

Shuhei Otsuki, Ph.D.

Natalie M. Pecheniuk, Ph.D.

Keith Stephenson, Ph.D.

Subramanian Yegneswaran, Ph.D.

Research Associates

Eun-Young Ahn, Ph.D.

Shinichi Asabe, Ph.D.

Marcy R. Auerbach, Ph.D.

Agnieszka A. Augustyniak, Ph.D.

Dong Bai, Ph.D.

Yajnavalka Banerjee, Ph.D.

Jennifer L. Barber-Singh, Ph.D.

Cristina Bongiorni, Ph.D.

Kristen E. Bower, Ph.D.***
CovX Research L.L.C.
San Diego, California

Nathan R. Brady, Ph.D.***
German Cancer Research Center
Heidelberg, Germany

Christoph Burkart, Ph.D.

Anna E. Cartier, Ph.D.***
University of California
San Diego, California

Giulio Cattarossi, Ph.D.

David M. Cauvi, Ph.D.

Yunchao Chang, Ph.D.

Yue Chen, Ph.D.

Guofeng Cheng, Ph.D.

Xiu Li Cong, M.D., Ph.D.

Chinh T. Dao, Ph.D.

Adam Denley, Ph.D.***
Freehills Patent Attorneys
Melbourne, Australia

Alejandra R. Diaz, Ph.D.***
Universidad Nacional del Sur
Buenos Aires, Argentina

Jonathon M. Flanagan, Ph.D.***
St. Jude Children's Research Hospital
Memphis, Tennessee

Tatsuya Fukushima, Ph.D.

Michael J. Giffin, Ph.D.

Shawn Patrick Grogan, Ph.D.

Marco Gymnopoulos, Ph.D.

David Habart, M.D., Ph.D.

Jonathan Hart, Ph.D.

Wolf-Achim Hassenpflug, M.D.***
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany

Dominik R. Haudenschild, Ph.D.

Matteo Iannacone, M.D.***
Harvard Medical School
Boston, Massachusetts

Masanori Isogawa, M.D.

Tatsuo Ito, M.D.***
Memorial Sloan-Kettering Cancer Center
New York, New York

Hao Jiang, Ph.D.

Daisy Vanitha John, Ph.D.

Sohye Kang, Ph.D.***
Amgen
Thousand Oaks, California

Sharookh B. Kapadia, Ph.D.***
Gilead Sciences, Inc.
Foster City, California

Pablo G. Landart, Ph.D.

Alan Yueh-Luen Lee, Ph.D.

Shi-Sheng Li, Ph.D.

Miao-Chia Lo, Ph.D.

Jiann-Kae Luo, Ph.D.***
Regeneron Pharmaceuticals, Inc.
Rensselaer, New York

Mihaela Lorger, Ph.D.

Holly N. Maier, Ph.D.***
Amylin Pharmaceuticals, Inc.
San Diego, California

Nathalie Malo, Ph.D.

Mathieu Marella, Ph.D.

Florent M. Martin, Ph.D.

Shinobu Matsuura, Ph.D.

Sebastien Mauen, Ph.D.

Yasunori Mishima, M.D.***
Kurume University School of Medicine
Kurume, Japan

Eiko Nakamaru-Ogiso, Ph.D.***
University of Pennsylvania
Philadelphia, Pennsylvania

Christian J. Nievera, Ph.D.

Maria S. Ninniri, Ph.D.

Akiko Okumura, Ph.D.

Fumihiko Okumura, Ph.D.

Petra Pavlickova, Ph.D.

Luke F. Peterson, Ph.D.

Pablo Perez Pinera, M.D.

Gian Marco Podda, M.D.

Natalia Reixach, Ph.D.

Rosamund Leila Reynald, Ph.D.

Bruno Sainz, Jr., Ph.D.

Stefaan J. Sansen, Ph.D.

Francesca Scaramozzino, Ph.D.

Jin Shi, Ph.D.

Wei-Jong Shia, Ph.D.

Karin Staflin, Ph.D.

Christina H. Swan, Ph.D.

Hendrik Szurmant, Ph.D.

Ken Takahashi, M.D.

Noboru Taniguchi, M.D., Ph.D.

Jesus Torres-Bacete, Ph.D.

Jaroslav Truksa, Ph.D.

Masanao Tsuda, Ph.D.***
Burnham Institute for Medical Research
La Jolla, California

Ji Wang, Ph.D.***
M.D. Anderson Cancer Center
Houston, Texas

Robert A. White, Ph.D.

Adam C. Wilson, Ph.D.

Tetsuo Yamashita, Ph.D.***
Kagawa University Faculty of Medicine
Kagawa, Japan

Xia Yang, Ph.D.

Zhengyi Ye, Ph.D.

Xiaoyan Yin, Ph.D.

Antonella Zampolli, Ph.D.Li Zhao, Ph.D.

Jin Zhong, Ph.D.

Weiguo Zou, Ph.D.***
Harvard School of Public Health
Boston, Massachusetts

Masahiko Zuka, M.D., Ph.D.***
Kanazawa University
Ishikawa, Japan

Scientific Associates

Fanny E. Almus, Ph.D.

Jose A. Fernandez, Ph.D.

Terri P. Gelbart, B.S., M.T.

Oxana A. Malakhova, M.S.

Byoung Boo Seo, Ph.D.

* Joint appointment in The Skaggs Institute for Chemical Biology
**Joint appointment in Department of Cell Biology
*** Appointment completed, new location shown

For larger image click here.

Protein C (PC), a serine protease zymogen, and its enzymatically active derivative, activated protein C (APC), are normal components of human blood. Discovery of the pathologic effects of hereditary PC deficiency in humans at Scripps Research helped lead to clinical trials that resulted in approvals of both PC and APC as drugs by the Food and Drug Administration. The decrease in mortality in patients with severe sepsis treated with recombinant APC gave impetus to new directions for basic and preclinical research on APC. A, APC is generated by the enzymatic action of thrombin (IIa) on endothelial cell membranes, where the endothelial PC receptor (EPCR) and thrombomodulin (TM) reversibly bind the reaction components. B, Dissociation of APC from EPCR (A) allows expression of APC anticoagulant activity involving proteolytic inactivation of 2 blood clotting cofactor proteins, Va (fV_a) and VIIIa (fVIII_a), by APC to yield the inactivated cofactors fV_i and fVIII_i. C, In contrast, binding of APC to EPCR on cells mediates expression of the multiple direct cellular activities of APC that require the 2 cellular receptors EPCR and protease-activated receptor 1 (PAR-1). Because of its pleiotropic activities, APC not only is useful in treatement of sepsis but also is promising as a potential treatment of other complex conditions such as thrombosis, ischemic stroke, and chronic neurodegenerative disorders. This figure was orignally published in Blood. Mosnier, L.O., Zlokovic, B.V., Griffin, J.H. The cytoprotective protein C pathway. Blood 109: 3161, 2007. ©The American Society of Hematology. Work done by Laurent Mosnier, Ph.D., research associate, in the laboratory of John H. Griffin, Ph.D., professor.

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