Scientific Report 2007

Chemistry

Chairman's Overview

Staff

K.C. Nicolaou, Ph.D.*
Professor and Chairman
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry

Phil Baran, Ph.D.
Associate Professor

Dale L. Boger, Ph.D.*
Richard and Alice Cramer Professor of Chemistry

Sydney Brenner, Ph.D.
Adjunct Professor

Charles Cho, Ph.D.
Adjunct Assistant Professor

Tobin J. Dickerson, Ph.D.
Assistant Professor

Albert Eschenmoser, Ph.D.*
Professor

Sheng Ding, Ph.D.
Assistant Professor

M.G. Finn, Ph.D.*
Associate Professor

Valery Fokin, Ph.D.
Associate Professor

M. Reza Ghadiri, Ph.D.*
Professor

William A. Greenberg, Ph.D.
Assistant Professor

Donald Hilvert, Ph.D.
Adjunct Professor

Inkyu Hwang, Ph.D.
Assistant Professor

Hayato Ishikawa, Ph.D.**
Assistant Professor
Tokyo University of Science
Tokyo, Japan

Kim D. Janda, Ph.D.***
Professor
Ely R. Callaway, Jr., Chair in Chemistry
Director, The Worm Institute for Research and Medicine

Jeffery W. Kelly, Ph.D.*
Lita Annenberg Hazen Professor of Chemistry
Dean, Graduate and Postgraduate Studies

Ramanarayanan Krishnamurthy, Ph.D.
Associate Professor

Richard A. Lerner, M.D.****
President, The Scripps Research Institute
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Evan Powers, Ph.D.
Assistant Professor

Julius Rebek, Jr., Ph.D.*
Professor
Director, The Skaggs Institute for Chemical Biology

Ed Roberts, Ph.D.
Professor

Floyd E. Romesberg, Ph.D.
Associate Professor

William R. Roush, Ph.D.*****
Professor
Associate Dean, Kellogg School of Science and Technology
Executive Director of Medicinal Chemistry, Scripps Florida

Peter G. Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
Professor
W.M. Keck Professor of Chemistry

Vaughn Smider, Ph.D.
Assistant Professor

Anita Wentworth, Ph.D.
Assistant Professor

Paul Wentworth, Jr., Ph.D.
Professor

Chi-Huey Wong, Ph.D.*
Ernest W. Hahn Professor and Chair in Chemistry

Xu Wu, Ph.D.
Adjunct Assistant Professor

Andrew Bin Zhou, Ph.D.
Assistant Professor

Staff Scientists

Lisa Eubanks, Ph.D

Rajesh Grover, Ph.D.

Byeong D. Song, Ph.D.

Lubica Supekova, Ph.D.

Wen Xiong, Ph.D.

Instrumentation Facilities

Raj K. Chadha, Ph.D.
Director, X-ray Crystallography Facility

Dee H. Huang, Ph.D.
Director, Nuclear Magnetic Resonance Facility

Gary E. Siuzdak, Ph.D.
Director, Mass Spectrometry Facility

Senior Research Associates

Ashraf Brik, Ph.D.**
Ben Gurion University of the Negev
Be'er-Sheva, Israel

Gunnar Kaufmann, Ph.D.

Research Associates

Xaiver Alvarez-Mico, Ph.D.**
Institute of Chemical and Engineering Sciences
Biopolis, Singapore

Lital Alfonta, Ph.D.**
Ben Gurion University of the Negev
Be'er-Sheva, Israel

Rajesh Ambasudhan, Ph.D.

Manuel Amorin Lopez, Ph.D.

Yoshio Ando, Ph.D.

Deboshri Banerjee, Ph.D.

Clay Bennett, Ph.D.

Moritz Biskup, Ph.D.

Anthony Boitano, Ph.D.

Brant Boren, Ph.D.**
Exelixis, Inc.
San Diego, California

Andrew Brogan, Ph.D.**
RTI Health Solutions
Research Triangle Park, North Carolina

Paul Bulger, Ph.D.**
Merck & Co., Inc.
Rahway, New Jersey

Kevin Bunker, Ph.D.**
Pfizer Inc.
La Jolla, California

Antonio Burtoloso, Ph.D.

Mark Bushey, Ph.D.

Darren Bykowski, Ph.D.

Petr Capek, Ph.D.

Katerina apkova, Ph.D.

Arani Chanda, Ph.D.

Sukbok Chang, Ph.D.**
Korea Advanced Institute of Science and Technology
Daejeon, South Korea

Ke Chen, Ph.D.

Shuo Chen, Ph.D.**
Ohio University
Athens, Ohio

Govardhan Cherukupalli, Ph.D.

Jodie Chin, Ph.D.

Charles Cho, Ph.D.

So-Hye Cho, Ph.D.

Sungwook Choi, Ph.D.

Scott Cockroft, Ph.D.

David Colby, Ph.D.

Kevin Cole, Ph.D

Jeromy Cottell, Ph.D.**
Gilead Science, Inc.
Foster City, California

Christine Crane, Ph.D.

James Crawford, Ph.D.**
AstraZeneca
Cheshire, England

Matthew Cremeens, Ph.D.

Jesse Dambacher, Ph.D.**
Infineum
Linden, New Jersey

Etzer Darout, Ph.D.

Sandra De Lamo Marin, Ph.D.^†

Amy DeBaillie, Ph.D.

Judith Denery, Ph.D.

Ross Denton, Ph.D.

Caroline Desponts, Ph.D.

Deguo Du, Ph.D.

Anna Dubrovska, Ph.D.

Joshua Dunetz, Ph.D.

Kyle Eastman, Ph.D.

David Edmonds, Ph.D.

Jan Elsner, Ph.D.Nil Emre, Ph.D.**
Millipore
Temecula, California

Cyrine Ezzili, Ph.D.

Raffaella Faraoni, Ph.D.**
Ambit Biosciences
San Diego, California

Simon Ficht, Ph.D.

Ted Foss, Ph.D.**
U.S. Genomics, Inc.
Woburn, Massachusetts

Joseph Rodolph Fotsing, Ph.D.

Bozena Frackowiak, Ph.D.

Graeme Freestone, Ph.D.

Yu Fu, Ph.D.

Jim Fuchs, Ph.D.**
Ohio State University
Columbus, Ohio

Amelia Fuller, Ph.D.

Doug Fowler, Ph.D.**
University of Washington
Seattle, Washington

Jianmin Gao, Ph.D.

Muyun Gao**
Genomics Institute of the Novartis Research Foundation
San Diego, California

Haibo Ge, Ph.D.

Savvas Georgiades, Ph.D.

Ola Ghoneim, Ph.D.

Nathan Gianneschi, Ph.D.

Romelo Gibe, Ph.D.**
Institute of Chemical and Engineering Sciences
Biopolis, Singapore

Christina Gil-Lamaignere, Ph.D.Neill Gingles, Ph.D.

Neil Grimster, Ph.D.

Jan Grunewald, Ph.D.

Jiantao Guo, Ph.D.

Richard Guy, Ph.D.

Akiyuki Hamasaki, Ph.D.**
UNITECH Co., Ltd.
Chiba, Japan

Masaki Handa, Ph.D.

Yuanjun He, Ph.D.

Jason Hein, Ph.D

Rodriguez Marcos Hernandez, Ph.D.

Par Holmberg, Ph.D.

Zhangyong Hong, Ph.D.

Tamara Hopkins, Ph.D.

Tsui-Ling Hsu, Ph.D.**
Genomics Research Center
Academia Sinica
Taipei, Taiwan

Fang Hu, Ph.D.

Xiaoyi Hu, Ph.D.

Zheng-Zheng Huang, Ph.D.**
Department of Molecular Biology, Scripps Research

Benjamin Hutchins, Ph.D.

Der-Ren Hwang, Ph.D.

Giltae Hwang, Ph.D.

Michael Jahnz, Ph.D.

Rong Jiang, Ph.D.

Steven Johnson, Ph.D.**
Department of Molecular Biology, Scripps Research

Hiroyuki Kakei, Ph.D.

Jaroslaw Kalisiak, Ph.D.

Kwang Mi Kim, Ph.D.

Mihyong Kim, Ph.D.

F. Scott Kimball, Ph.D.

Ravinder Reddy Kondreddi, Ph.D.**
Novartis, Inc.
Keppel Towers, Singapore

Keith Korthals, Ph.D.

Larisa Krasnova, Ph.D.

Tsun-Hun Kuo, Ph.D.

Jane Kuzelka, Ph.D.**
Calmune, Corp.
San Diego, California

Andreas Lanver, Ph.D.**
BASF AG
Ludwigshafen, Germany

Brian Lawhorn, Ph.D.**
GlaxoSmithKline
King of Prussia, Pennsylvania

Jae Wook Lee, Ph.D.

Jinq-Chyi Lee, Ph.D.

Jongkook Lee, Ph.D.

JongSeok Lee, Ph.D.

Ki-Bum Lee, Ph.D.

Kooyeon Lee, Ph.D.^†

Sejin Lee, Ph.D.

Lucas Leman, Ph.D.

Alexandre Lemire, Ph.D.

Edward Lemke, Ph.D.

Achim Lenzin, Ph.D.^†

Christophe Letondor, Ph.D.

Chuang-Chuang Li, Ph.D

Fangzheng Li, Ph.D.

Hongming Li, Ph.D.

Ke Li, Ph.D.

Pi-Hui Liang, Ph.D.

Yeon-Hee Lim, Ph.D.

Tongxiang Lin, Ph.D.

Troy Lister, Ph.D.

Chris Liu, Ph.D.

Lei Liu, Ph.D.**
Tsinghua University
Beijing, China

Wenshe Liu, Ph.D.

Ying (Cindy) Liu, Ph.D.**
Catalyst Biosciences, Inc.
South San Francisco, California

Hongzheng (Eric) Ma, Ph.D.**
Pioneer Hi-Bred International, Inc.
Johnston, Iowa

Nello Mainolfi, Ph.D.**
Novartis Pharmaceuticals
Cambridge, Massachusetts

Shigeo Matsuda, Ph.D.

Michael Maue, Ph.D.^†

Alexander Mayorov, Ph.D.

Laura McAllister, Ph.D.**
Novartis
Horsham, England

Kathleen McKenzie, Ph.D.^†

Charles Melancon, Ph.D.

Gopi-Kumar Mittapalli, Ph.D.**
Immusol, Inc.
San Diego, California

Ana Montero, Ph.D.

Miguel Morales, Ph.D.Adam Morgan, Ph.D.^†

Tingwei Mu, Ph.D.

Mridul Mukherji, Ph.D.^†

Kenichiro Nagai, Ph.D.**
Kitasato University
Tokyo, Japan

Yuya Nakai, Ph.D.

Joonwoo Nam, Ph.D.

Tae-gyu Nam, Ph.D.

Andrew Nguyen, M.D., Ph.D.

Daniel Nicoletti, Ph.D.^†

George Nora, Ph.D.

Michael Ober, Ph.D.**
DuPont Virginia
Richmond, Virginia

Barun Okram, Ph.D.**
Genomics Institute of the Novartis Research Foundation
San Diego, California

Christian Olsen, Ph.D.

Yazmin Osornio, Ph.D.

Doron Pappo, Ph.D.**
Institute of Chemical and Engineering Sciences
Biopolis, Singapore

Junguk Park, Ph.D.

Laxman Pasunoori, Ph.D.^†

Johan Paulsson, Ph.D.

Goran Petrovic, Ph.D.**
Senomyx, Inc.
San Diego, California

Damien Polet, Ph.D.**
Institute of Chemical and Engineering Sciences
Biopolis, Singapore

Guido Pontremoli, Ph.D.^†Richard Payne, Ph.D.

Xuemei Peng, Ph.D.

Murali Peram Surakattula, Ph.D.

Roshan Perera, Ph.D.

Suresh Pitram, Ph.D.

Ramulu Poddutoori, Ph.D.

Jonathan Pokorski, Ph.D.

Tülay Polat, Ph.D.**
Abraxis Bioscience, Inc.
Los Angeles, California

Praveen Rao, Ph.D.

Daniela Radu, Ph.D.

Ronald Rahaim, Ph.D.

Fatima Rivas, Ph.D.

F. Anthony Romero, Ph.D.**
Merck Research Laboratories
Rahway, New Jersey

Joshua Roth, Ph.D.

Troy Ryba, Ph.D.

Youngha Ryu, Ph.D.

Vasudeva Naidu Sagi, Ph.D.

Alain Salameh, Ph.D.^†

Antonio Sanchez-Ruiz, Ph.D.

Nicholas Salzameda, Ph.D.

Yoshikazu Sasaki, Ph.D.

Stefan Schiller, Ph.D.

Laura Segatori, Ph.D.**
Rice University
Houston, Texas

Edward Sessions, Jr., Ph.D.

Shigeki Seto, Ph.D.

Mary Sever, Ph.D.

avid Shaw, Ph.D.

Michael Smolinski, Ph.D.

Alex Shaginian, Ph.D.

Weijun Shen, Ph.D.

Yan Shi, Ph.D.

Rituparna Sinha Roy, Ph.D.

Xinyi Song, Ph.D.

Simon Stamm, Ph.D.

Sebastian Steiniger, Ph.D.

Antonia Stepan, Ph.D.

James Stover, Ph.D.

Shun Su, Ph.D.

Daniel Summerer, Ph.D.**
Febit Biomed GmbH
Heidelberg, Germany

Takahiro Suzuki, Ph.D.**
Institute of Chemical and Engineering Sciences
Biopolis, Singapore

Leo Takaoka, Ph.D.**
Schering-Plough Research Institute
Cambridge, Massachusetts

Shinobu Takizawa, Ph.D.

Adam Talbot, Ph.D.

Yefeng Tang, Ph.D.

Eric Tippmann, Ph.D.**
Cardiff University
London, England

Mariola Tortosa, Ph.D.

Vincent Trepanier, Ph.D

Jonathan Tripp, Ph.D.

Craig Turner, Ph.D.^†

Meng-Lin Tsao, Ph.D.**
University of California
Merced, California

Andrew Udit, Ph.D.

Taiki Umezawa, Ph.D.

Kenji Usui, Ph.D.

Carlos Valdez, Ph.D.

Bo Wang, Ph.D.^†

Hong Wang, Ph.D.**
Miami University
Oxford, Ohio

Jian Wang, Ph.D.

Jiangyun Wang, Ph.D.

Lin Wang, Ph.D.

Weidong Wang, Ph.D.

Xiaolong Wang, Ph.D.**
Pfizer Inc.
La Jolla, California

Timo Weide, Ph.D.

Matthew Whiting, Ph.D.**
GlaxoSmithKline
Stevenage, England

Amie Williams, Ph.D.**
GlaxoSmithKline
Durham, North Carolina

Albert Willis, III, Ph.D.

Douglass Wu, Ph.D.**
Optimer Pharmaceuticals, Inc.
San Diego, California

Tao Wu, Ph.D.

Heiko Wurdak, Ph.D.

Jian Xie, Ph.D.

Yue Xu, Ph.D.

Junichiro Yamaguchi, Ph.D.

Ryu Yamasaki, Ph.D.**
Tokyo University of Science
Tokyo, Japan

Lei Yao, Ph.D.**
Harvard Medical School
Boston, Massachusetts

Ura Yasuyuki, Ph.D.

Zhanqian Yu, Ph.D.

Hongjun Zhang, Ph.D.

Qisheng Zhang, Ph.D.**
University of North Carolina
Chapel Hill, North Carolina

Xuejun Zhang, Ph.D.

Yingchao Zhang, Ph.D.

Heyue Henry Zhou, Ph.D.

Xiuwen Zhu, Ph.D.

Joerg Zimmermann, Ph.D.

Caterina Zoni, Ph.D.^†

Visiting Investigators

Mohammad Al-Sayah, Ph.D.**
American University of Sharjah
Sharjah, United Arab Emirates

Masakazu Fujio, Ph.D.**
Mitsubishi Pharma Corporation
Yokohama, Japan

Keisuke Fukuchi, Ph.D.
Sankyo Co., Ltd.
Tokyo, Japan

Yoshiyuki Hari, Ph.D.
Nagoya City University
Nagoya, Japan

Christine Hernandez, Ph.D.
University of the Philippines, Diliman
Quezon City, Philippines

Masakazu Imamura, Ph.D.
Astellas Pharmaceutical Inc., Co., Ltd.
Ushiku-shi, Japan

Kuniyuki Kishikawa, Ph.D.
Kyowa Hakko Kogyo Co., Ltd.
Sunto-gun, Japan

Michael Meijler, Ph.D.
Ben Gurion University of the Negev
Be'er-Sheeva, Israel

Poul Nielsen, Ph.D.
University of Southern Denmark
Odense M, Denmark

Masakazu Sugiyama, Ph.D.**
Ajinomoto Co., Inc.
Kawasaki, Japan

Takayoshi Suzuki, Ph.D.
Nagoya City University
Nagoya, Japan

Shin-Ichi Takanashi, Ph.D.**
Mitsubishi
Kawasaki, Japan

Ken-ichi Takao, Ph.D.**
Keio University
Yokohama, Japan

Yoshiyuki Yoneda, Ph.D.
Daiichi Pharmaceutical Co., Ltd.
Tokyo, Japan

Scientific Associates

Jon Ashley

Gina Dendle

Suresh Mahajan, Ph.D.

Jonathan Zhu, Ph.D.

* Joint appointment in The Skaggs Institute for Chemical Biology
** Appointment completed; new location shown
*** Joint appointments in the Skaggs Institute for Chemical Biology and the Department of Immunology
**** Joint appointments in The Skaggs Institute for Chemical Biology and the Department of Molecular Biology
***** Scripps Florida
^†Appointment completed