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Scientific Report 2006


Molecular and Experimental Medicine





Chairman's Overview

Staff


Ernest Beutler, M.D.*
Chairman and Professor
Head, Division of Hematology

Masahiro Aoki, M.D., Ph.D.
Adjunct Assistant Professor

Hiroshi Asahara, M.D., Ph.D.
Assistant Professor

Bonno N. Bouma, Ph.D.
Adjunct Professor

Joel N. Buxbaum, M.D.
Professor
Head, Division of Research Rheumatology

Dennis A. Carson, M.D.
Adjunct Professor

Sergio D. Catz, Ph.D.
Assistant Professor

Francis V. Chisari, M.D.
Professor
Head, Division of Experimental Pathology

Clifford W. Colwell, Jr., M.D.
Adjunct Professor

Laura M. Crisa, M.D.
Assistant Professor

Arthur D. Dawson, M.D.
Adjunct Professor

Albert B. Deisseroth, M.D., Ph.D.
Adjunct Professor

Gregory J. del Zoppo, M.D.**
Associate Professor

Thomas F. Deuel, M.D.
Professor
Head, Division of Molecular Oncology

Darryl D’Lima, M.D.
Assistant Professor

Darlene J. Elias, M.D.
Adjunct Associate Professor

Brunehilde Felding-Habermann, Ph.D.
Associate Professor

Mitchell H. Friedlaender, M.D.
Adjunct Professor

Jeffrey S. Friedman, M.D., Ph.D.
Assistant Professor

Theodore Friedmann, M.D.
Adjunct Professor

Andrew J. Gale, Ph.D.
Assistant Professor

Roberta A. Gottlieb, M.D.
Associate Professor

John H. Griffin, Ph.D.**
Professor

Andras Gruber, M.D.
Adjunct Assistant Professor

Luca G. Guidotti, D.V.M., Ph.D.
Associate Professor

Asa B. Gustafsson, Ph.D.
Assistant Professor

Anne M. Hanneken, M.D.
Associate Professor

Mary J. Heeb, Ph.D.**
Associate Professor

James A. Hoch, Ph.D.
Professor
Head, Division of Cellular Biology

Frank M. Huennekens, Ph.D.
Professor Emeritus

Shaun Phillip Jackson, Ph.D.
Adjunct Associate Professor

Eric F. Johnson, Ph.D.
Professor
Acting Head, Division of Biochemistry

Thomas J. Kipps, M.D., Ph.D.
Adjunct Professor

Lawrence E. Kline, D.O.
Adjunct Associate Professor

James A. Koziol, Ph.D.
Professor
Head, Division of Biomathematics

Daniel F. Kripke, M.D
Adjunct Professor

Thomas J. Kunicki, Ph.D.*
Associate Professor

Pauline L. Lee, Ph.D.
Associate Professor

Stuart A. Lipton, M.D., Ph.D.
Adjunct Professor

Martin Lotz, M.D.
Professor
Head, Division of Arthritis Research

Christopher Lee Marsh, M.D.
Adjunct Associate Professor

Robert McMillan, M.D.
Professor Emeritus

William E. Miller, M.D.
Adjunct Assistant Professor

Kevin V. Morris, Ph.D.
Assistant Professor

Jorge J. Nieva, M.D.
Assistant Professor

Marta Perego, Ph.D.
Associate Professor

Paul J. Pockros, M.D.
Adjunct Assistant Professor

K. Michael Pollard, Ph.D.
Associate Professor

Giuseppe Remuzzi, M.D.
Adjunct Professor

Michael W. Robertson, Ph.D.
Associate Professor

Zaverio M. Ruggeri, M.D.**
Professor
Head, Division of Experimental Hemostasis and Thrombosis

Enrique Saldivar, M.D., Ph.D.
Adjunct Assistant Professor

Daniel R. Salomon, M.D.
Associate Professor

Alessandro Sette, Ph.D.
Adjunct Professor

Farhad F. Shadan, M.D., Ph.D.
Adjunct Assistant Professor

Sanford J. Shattil, M.D.
Adjunct Professor

Alexander R. Shikhman, M.D., Ph.D.
Adjunct Assistant Professor

Inmaculada Silos-Santiago, M.D., Ph.D.
Adjunct Associate Professor

Gregg J. Silverman, M.D.
Adjunct Professor

Ronald A. Simon, M.D.
Adjunct Professor

Peter J. Sims, M.D., Ph.D.***
Professor
University of Rochester
Rochester, New York

Jack C. Sipe, M.D.
Associate Professor

Donald D. Stevenson, M.D.
Adjunct Professor

Eng M. Tan, M.D.
Professor Emeritus

Bruce E. Torbett, Ph.D.
Associate Professor

Susan L. Uprichard, Ph.D.
Assistant Professor

Kottayil I. Varughese, Ph.D.**
Associate Professor

Peter K. Vogt, Ph.D.
Professor
Head, Division of Oncovirology

Matthias G. von Herrath, M.D.
Adjunct Associate Professor

Therese Wiedmer, Ph.D.***
Associate Professor
University of Rochester
Rochester, New York

Xiaohua Wu, Ph.D.
Assistant Professor

Takao Yagi, Ph.D.
Associate Professor

Dong-Er Zhang, Ph.D.
Associate Professor

Staff Scientists

Andreas G. Bader, Ph.D.

Joseph R. Biggs, Ph.D.

Reha Celikel, Ph.D.

Mei-Hui Hsu, Ph.D.

Chengqun Huang, M.D., Ph.D.

Jennifer L. Johnson, Ph.D.

Klaus Kuhn, Ph.D.

Sunil M. Kurian, Ph.D.

Patrizia Marchese, Ph.D.

Tsaiwei Olee, Ph.D.

Brian Savage, Ph.D.Uzen Savas, Ph.D.

Stefan Wieland, Ph.D.

Akemi Yagi, Ph.D.

Ji Zhao, Ph.D.***
Department of Biomedical Sciences
Scripps Florida

Quansheng Zhou, Ph.D.

Senior Research Associates

Hiroshi Deguchi, M.D., Ph.D.

Yuichi Kamikubo, Ph.D.

Richard D. Milner, M.D., Ph.D.

Laurent O. Mosnier, Ph.D.

Deirdre M. O'Sullivan, Ph.D.

Keith Stephenson, Ph.D.

Jill M. Waalen, M.D.

Subramanian Yegneswaran, Ph.D.

Research Associates

Eun-Young Ahn, Ph.D.

Shinichi Asabe, Ph.D.

Dong Bai, Ph.D.

Jennifer L. Barber-Singh, Ph.D.

Cristina Bongiorni, Ph.D.

Kristen E. Bower, Ph.D.

Anita Y. Boyapati, Ph.D.

Nathan R. Brady, Ph.D.

Katia Maria Cabral, Ph.D.

Anna E. Cartier, Ph.D.Giulio Cattarossi, Ph.D.

David M. Cauvi, Ph.D.

Yunchao Chang, Ph.D.

Emily I. Chen, Ph.D.

Guofeng Cheng, Ph.D.

Stephanie Cherqui, Ph.D.

Ian D. Dang, Ph.D.***
United States Patent and Trademark Office
Rockville, Maryland

Chinh T. Dao, Ph.D.

Maria F. Del Papa, Ph.D.

Adam Denley, Ph.D.

Alejandra R. Diaz, Ph.D.

Jonathon M. Flanagan, Ph.D.

Tatsuya Fukushima, Ph.D.

Michael J. Giffin, Ph.D.

Shawn Patrick Grogan, Ph.D.

Marco Gymnopoulos, Ph.D.

Wolf-Achim Hassenpflug, M.D.

Dominik R. Haudenschild, Ph.D.

Gonzalo Herradon, Ph.D.

Matteo Iannacone, M.D.

Masanori Isogawa, M.D.

Tatsuo Ito, M.D.

Hao Jiang, Ph.D.

Sohye Kang, Ph.D.

Mou-Chieh Kao, Ph.D.***
National Tsing Hua University
Hsinchu, Taiwan

Sharookh B. Kapadia, Ph.D.

Jung Hwan Kim, Ph.D.

Joseph S. Krueger, Ph.D.

Pablo G. Landart, Ph.D.

Alan Yueh-Luen Lee, Ph.D.

Shi-Sheng Li, Ph.D.

Enbo Liu, Ph.D.***
The Burnham Institute
La Jolla, California

Miao-Chia Lo, Ph.D.

Jiann-Kae Luo, Ph.D.

Holly N. Maier, Ph.D.

Mathieu Marella, Ph.D.

Florent M. Martin, Ph.D.

Yuri Martina, Ph.D.***
Adaltis
Rome, Italy

Yasunori Mishima, M.D.

Daniela Beatriz Munafo, Ph.D.

Eiko Nakamaru-Ogiso, Ph.D.

Akiko Okumura, Ph.D.

Fumihiko Okumura, Ph.D.

Erin N. Olson, Ph.D.

Mee Young Park, Ph.D.

Natalie M. Pecheniuk, Ph.D.

Luke F. Peterson, Ph.D.

Pablo Perez Pinera, M.D.

Gian Marco Podda, M.D.

Natalia Reixach, Ph.D.

Rosamund Leila Reynald, Ph.D.

Bruno Sainz, Jr., Ph.D.

Stefaan J. Sansen, Ph.D.

Francesca Scaramozzino, Ph.D.

Jin Shi, Ph.D.

Misako Shibakura, Ph.D.***
Okayama University Medical School
Okayama, Japan

Christina H. Swan, Ph.D.

Hendrik Szurmant, Ph.D.

Noboru Taniguchi, M.D.

Jesus Torres-Bacete, Ph.D.

Jaroslav Truksa, Ph.D.

Masanao Tsuda, Ph.D.

Billyana C. Tsvetanova, Ph.D.

Ji Wang, Ph.D.

Yang Wang, Ph.D.***
University of Texas
MD Anderson Cancer Center
Houston, Texas

Zhuangzhi Wang, Ph.D.

Martin R. Weber, Ph.D.***
Bristol Myers-Squibb Pharmaceutical Research Institute
Wallingford, Connecticut

Andrea K. White, Ph.D.***
Chico State University
Chico, California

Robert A. White, Ph.D.

Adam C. Wilson, Ph.D.

Tetsuo Yamashita, Ph.D.

Ming Yan, Ph.D.

Xia Yang, Ph.D.
Jason K. Yano, Ph.D.***

Takeda San Diego, Inc.
San Diego, California

Zhengyi Ye, Ph.D.

Jinseong Yi, Ph.D.

Xiaoyan Yin, Ph.D.

Antonella Zampolli, Ph.D.

Wei Zhang, Ph.D.

Li Zhao, Ph.D.

Jin Zhong, Ph.D.

Weiguo Zou, Ph.D.

Masahiko Zuka, M.D., Ph.D.

Scientific Associates

Fanny E. Almus, Ph.D.

Jose A. Fernandez, Ph.D.

Gabriele E. Foos, Ph.D.

Terri P. Gelbart, B.S., M.T.

Byoung Boo Seo, Ph.D.

* Joint appointment in The Skaggs Institute for Chemical Biology
** Joint appointment in Department of Cell Biology
*** Appointment completed, new location shown

 


Within the “neurovascular unit” neuron activation controls microvascular vasoreactivity via the astrocytes, which are a necessary part of the microvessel. During ischemic stroke, microvessel and neuron activation occur rapidly and simultaneously. Members of Gregory del Zoppo’s laboratory have demonstrated that loss of vascular basal lamina matrix with the rapid generation of pro-MMP-2, its activation systems, and other proteases accompany neuron injury. Furthermore, when the endothelial blood-brain barrier becomes permeable, fibrin is deposited in microvessels where thrombin is generated when plasma contacts perivascular tissue factor (TF). Recently, the laboratory has shown that tissue factor pathway inhibitor (TFPI) is also generated by the endothelium and by activated microglial cells in the ischemic regions. These alterations are part of the evolution of injury in the neurovascular unit. Illustration prepared by Janet Hightower.