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Scientific Report 2006


Chemistry





Chairman's Overview

Staff


K.C. Nicolaou, Ph.D.*
Professor and Chairman
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry

Phil Baran, Ph.D.
Associate Professor

Dale L. Boger, Ph.D.*
Richard and Alice Cramer Professor of Chemistry

Tobin J. Dickerson, Ph.D.
Assistant Professor

Albert Eschenmoser, Ph.D.*
Professor

Sheng Ding, Ph.D.
Assistant Professor

M.G. Finn, Ph.D.*
Associate Professor

Valery Fokin, Ph.D.
Associate Professor

M. Reza Ghadiri, Ph.D.*
Professor

William A. Greenberg, Ph.D.
Assistant Professor

Inkyu Hwang, Ph.D.
Assistant Professor

Hayato Ishikawa, Ph.D.
Assistant Professor

Kim D. Janda, Ph.D.**
Professor
Ely R. Callaway, Jr., Chair in Chemistry
Director, The Worm Institute for Research and Medicine

Jeffery W. Kelly, Ph.D.*
Lita Annenberg Hazen Professor of Chemistry
Dean, Graduate and Postgraduate Studies

Ramanarayanan Krishnamurthy, Ph.D.
Associate Professor

Richard A. Lerner, M.D.***
President, The Scripps Research Institute
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Masayuki Matsushita, Ph.D.****
Chugai Pharmaceutical Co., LTD.
Tokyo, Japan

Michael Meijler, Ph.D.
Assistant Professor

Jorge J. Nieva, M.D.
Assistant Professor

Evan Powers, Ph.D.
Assistant Professor

Julius Rebek, Jr., Ph.D.*
Professor
Director, The Skaggs Institute for Chemical Biology

Ed Roberts, Ph.D.
Professor

Floyd E. Romesberg, Ph.D.
Associate Professor

Peter G. Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
Professor
W.M. Keck Professor of Chemistry

Vaughn Smider, Ph.D.
Assistant Professor

Anita Wentworth, Ph.D.
Assistant Professor

Paul Wentworth, Jr., Ph.D.
Professor

Chi-Huey Wong, Ph.D.*
Ernest W. Hahn Professor and Chair in Chemistry

Andrew Bin Zhou, Ph.D.
Assistant Professor

Staff Scientists

Byeong D. Song, Ph.D.

Lubica Supekova, Ph.D.

Wen Xiong, Ph.D.

Instrumentation/Service Facilities

Raj K. Chadha, Ph.D.
Director, X-Ray Crystallography Facility

Dee H. Huang, Ph.D.
Director, Nuclear Magnetic Resonance Facility

Gary E. Siuzdak, Ph.D.
Director, Mass Spectrometry Facility

Senior Research Associates

Ashraf Brik, Ph.D.

Yanping Chen, Ph.D.

Gunnar Kaufmann, Ph.D.

Research Associates

Ramzey Abujarour, Ph.D.****
Genomics Institute of the Novartis Research Foundation
San Diego, California

Dariush Ajami, Ph.D.

Lital Alfonta, Ph.D.

Xaiver Alvarez-Mico, Ph.D.

Rahesh Ambasudhan, Ph.D.

Narendra B. Ambhaikar, Ph.D.****
Vertex Pharmaceuticals
San Diego, California

Stellios Arseniyadis, Ph.D.****
Ecole Supérieure de Physique et de Chimie Industrielle
Paris, France

Gonen Ashkenasy, Ph.D.****
Ben-Gurion University of the Negev
Beer-Sheeva, Israel

Nurit Ashkenasy, Ph.D.****
Ben-Gurion University of the Negev
Beer-Sheva, Israel

Masato Atsumi, Ph.D.****
Kyocera JMM
Osaka, Japan

Elizabeth Barrett, Ph.D.

Christoph Behrens, Ph.D.****
University of Gottingen
Gottingen, Germany

Clay Bennett, Ph.D.

Jan Bieschke, Ph.D.****
Max Delbrück Center for Molecular Medicine
Berlin, Germany

Babu Boga, Ph.D.****
Schering Plough
Redminster, New Jersey

Anthony Boitano, Ph.D.

Venkataiah Bollu, Ph.D.

Brant Boren, Ph.D.

Daryl Bosco, Ph.D.****
Serono, Inc.
Boston, Massachusetts

Andrew Brogan, Ph.D.

Adrian Brunkhorst, Ph.D.*****

Paul Bulger, Ph.D.

Kevin Bunker, Ph.D.

Antonio Burtoloso, Ph.D.

Mark Bushey, Ph.D.

Sara Butterfield, Ph.D.

Alexandre Carella, Ph.D.

Michael Cassidy, Ph.D.****
Bristol-Myers Squibb
New Brunswick, New Jersey

Sukbok Chang, Ph.D.

Shuo Chen, Ph.D.

Yanping Chen, Ph.D.*****

Jodie Chin, Ph.D.

Charles Cho, Ph.D.

So-Hye Cho, Ph.D.

Scott Cockroft, Ph.D.

Kevin Cole, Ph.D.

Antonella Converso, Ph.D.****
Merck & Co., Inc.
West Point, Pennsylvania

Jeromy Cottell, Ph.D.

James Crawford, Ph.D.

Matthew Cremeens, Ph.D.

Jesse Dambacher, Ph.D.

Sandra De Lamo Marin, Ph.D.

Ross Denton, Ph.D.

Caroline Desponts, Ph.D.

David Diaz-Diaz, Ph.D.****
Universidad Autónoma de Madrid
Madrid, Spain

Christine Dierks, Ph.D.****
Genomics Institute of the Novartis Research Foundation
San Diego, California

David Edmonds, Ph.D.

Greg Elliott, Ph.D.****
Moore Cancer Center
La Jolla, California

Jan Elsner, Ph.D.

Nil Emre, Ph.D.

Lisa Eubanks, Ph.D.

Cyrine Ezzili, Ph.D.

Raffaella Faraoni, Ph.D.****
Ambit Biosciences
San Diego, California

Simon Ficht, Ph.D.

Laura Flatauer, Ph.D.****
Genomics Institute of the Novartis Research Foundation
San Diego, California

Ted Foss, Ph.D.

Joseph Rodolph Fotsing, Ph.D.

Rebecca Fraser, Ph.D.****
Novartis Pharma AG
Horsham, England

Graeme Freestone, Ph.D.

Jim Fuchs, Ph.D.

Amelia Fuller, Ph.D.

Jianmin Gao, Ph.D.

Muyun Gao, Ph.D.

Ola Ghoneim, Ph.D.

Nathan Gianneschi, Ph.D.

Romelo Gibe, Ph.D.
Institute of Chemical and Engineering Sciences
Jurong Island, Singapore, China

Christina Gil-Lamaignere, Ph.D.

Neill Gingles, Ph.D.

Naran Gombosuren, Ph.D.

Rajesh K. Grover, Ph.D.

Jan Grunewald, Ph.D.Sayam Sen Gupta, Ph.D.****
Technical University Munich
Munich, Germany

Richard Guy, Ph.D.

Clemens Haas, Ph.D.*****

Akiyuki Hamasaki, Ph.D.

Wooseok Han, Ph.D.****
Chiron
Emeryville, California

Frank Hauke, Ph.D.****
University of Erlangen
Erlangen, Germany

Jason Hein, Ph.D.

Mark Hixon, Ph.D.****
Takeda
San Diego, California

Jiyong Hong, Ph.D.****
Duke University
Durham, North Carolina

Sukwon Hong, Ph.D.****
University of Florida
Gainsville, Florida

Zhangyong Hong, Ph.D.

Richard Hooley, Ph.D.

Daniel Horne, Ph.D.****
Amgen
Thousand Oaks, California

Tsui-Ling Hsu, Ph.D.

Zheng-Zheng Huang, Ph.D.

Amy Hurshman, Ph.D.****
Joint Science Department of the Claremont Colleges
Claremont, California

Der-Ren Hwang, Ph.D.

Giltae Hwang, Ph.D.

Tetsuo Iwasawa, Ph.D.

Michael Jahnz, Ph.D.

Wei Jin, Ph.D.Steven Johnson, Ph.D.

Jaroslaw Kalisiak, Ph.D.

Michael Kelso, Ph.D.****
University of Wollongong
Wollongong, Australia

Gyungyoun Kim, Ph.D.****
SK Biopharmaceuticals
Fairfield, New Jersey

F. Scott Kimball, Ph.D.

Ravinder Reddy Kondreddi, Ph.D.

Larisa Krasnova, Ph.D.

Jane Kuzelka, Ph.D.

Andreas Lanver, Ph.D.

Brian Lawhorn, Ph.D.

Jinq-Chyi Lee, Ph.D.

Jongkook Lee, Ph.D.

JongSeok Lee, Ph.D.

Ki-Bum Lee, Ph.D.

Kooyeon Lee, Ph.D.

Sang Hyup Lee, Ph.D.****
LG Life Sciences
Daejeon, South Korea

Sejin Lee, Ph.D.

Lucas Leman, Ph.D.

Alexandre Lemire, Ph.D.

Edward Lemke, Ph.D.

Achim Lenzin, Ph.D.

Hongming Li, Ph.D.

Ke Li, Ph.D.

Pi-Hui Liang, Ph.D.

Jiayu Liao, Ph.D.****
University of California
Riverside, California

Yeon-Hee Lim, Ph.D.

Troy Lister, Ph.D.

Chris Liu, Ph.D.

Haitian Liu, Ph.D.****
Senomyx, Inc.
La Jolla, California

Jun Liu, Ph.D.****
Genomics Institute of the Novartis Research Foundation
San Diego, California

Lei Liu, Ph.D.

Wenshe Liu, Ph.D.

Yi Liu, Ph.D.****
Lawrence Berkeley National Laboratory
Berkeley, California

Ying (Cindy) Liu, Ph.D.

Dimitrios Lizos, Ph.D.****
Novartis Pharmaceuticals
Basil, Switzerland

Jon Loren, Ph.D.****
Genomics Institute of the Novartis Research Foundation
San Diego, California

Hongzheng (Eric) Ma, Ph.D.

Roman Manetsch, Ph.D.****
University of South Florida
Tampa, Florida

Enrique Mann, Ph.D.

Felix Marr, Ph.D.*****

Carol Lamenca Martinez, Ph.D.****
Berlin, Germany

Shigeo Matsuda, Ph.D.

Klaus-Dieter Michael Maue, Ph.D.

Laura McAllister, Ph.D.

Kathleen McKenzie, Ph.D.

Robert Milburn, Ph.D.****
Amgen
Thousand Oaks, California

Kyung-Hoon Min, Ph.D.*****

Christos A. Mitsos, Ph.D.****
Athens, Greece

Gopi Kumar Mittapalli, Ph.D.

Lionel Moisan, Ph.D.

Ana Montero, Ph.D.

Miguel Morales, Ph.D.

Tingwei Mu, Ph.D.

Mridul Mukherji, Ph.D.

Andrew Myles, Ph.D.****
University of Alberta
Edmonton, Canada

Kenichiro Nagai, Ph.D.

Yuya Nakai, Ph.D.

Joonwoo Nam, Ph.D.

Sridhar Narayan, Ph.D.****
Eisai Research Institute
Wilmington, Massachusetts

Daniel Nicoletti, Ph.D.

Alain Noncovich, Ph.D.****
Senomyx Inc.
La Jolla, California

Yasuo Norikane, Ph.D.****
Nanotechnology Research Institute, AIST
Tsukuba, Japan

Mehdi Numa, Ph.D.****
Vertex Pharmaceuticals Incorporated
San Diego, California

Severin Odermatt, Ph.D.

Barun Okram, Ph.D.

Peter Orahovats, Ph.D.

Yazmin Osornio, Ph.D.

Charles Papageorgiou, Ph.D.****
Amgen
Cambridge, Massachusetts

Doron Pappo, Ph.D.

Junguk Park, Ph.D.

Laxman Pasunoori, Ph.D.

Richard Payne, Ph.D.

Murali Peram Surakattula, Ph.D.

Roshan Perera, Ph.D.

Goran Petrovic, Ph.D.

Jared Piper, Ph.D.****
Eli Lilly
Indianapolis, Indiana

Suresh Pitram, Ph.D.

Tülay Polat, Ph.D.

Damien Poliet, Ph.D.

Guido Pontremoli, Ph.D.

Mariceli Puga, Ph.D.

Sreenivas Punna, Ph.D.****
ChemoCentryx, Inc.
Mountain View, California

Daniela Radu, Ph.D.

Nicole Rahe, Ph.D.****
Tesa AG
Hamburg, Germany

Shai Rahimipour, Ph.D.****
Bar-Ilan University
Ramat-Gan, Isreal

Praveen Rao, Ph.D.

Dalit Rechavi-Robinson, Ph.D.****
University of Geneva
Geneva, Switzerland

Stefanie Roeper, Ph.D.*****
Vertex Pharmaceuticals
Cambridge, Massachusetts

F. Anthony Romero, Ph.D.

Youngha Ryu, Ph.D.

Riccardo Salvio, Ph.D.

Anu Sawkar, Ph.D.****
Ropes & Gray
New York, New York

Patrick Schanen, Ph.D.****
ETH Zürich, Laboratory of Organic Chemistry
Zurich, Switzerland

Stefan Schiller, Ph.D.

Daniel Schlawe, Ph.D.****
Syncom BV
Groningen, the Netherlands

Michael Schramm, Ph.D.

Laura Segatori, Ph.D.

Mary Sever, Ph.D.

Alex Shaginian, Ph.D.

David Shaw, Ph.D.

Junhwa Shin, Ph.D.****
Korea Atomic Energy Research Institute
Seoul, Korea

Sebastian Steiniger, Ph.D.

Shula Stokols, Ph.D.****
W. L. Gore & Associates
Flagstaff, Arizona

Ji Young Suk, Ph.D.****
Merck Research Laboratories
Boston, Massachusetts

Daniel Summerer, Ph.D.

Takahiro Suzuki, Ph.D.

Leo Takaoka, Ph.D.

Eric Tippmann, Ph.D.

Jonathan Tripp, Ph.D.

Meng-Lin Tsao, Ph.D.

Craig Turner, Ph.D.

Jim Turner, Ph.D.****
Fish & Richardson P.C.
San Diego, California

Andrew Udit, Ph.D.

Taiki Umezawa, Ph.D.

Yasuyuki Ura, Ph.D.

Kenji Usui, Ph.D.

Juraj Velcicky, Ph.D.****
Novartis
Basel, Switzerland

Alessandro Volonterio, Ph.D.****
Politencino di Milano
Milano, Italy

Hong Wang, Ph.D.

Jiangyun Wang, Ph.D.

Weidong Wang, Ph.D.

Xiaolong Wang, Ph.D.

Timo Weide, Ph.D.

Lisa Whalen, Ph.D.****
University of New Mexico
Albuquerque, New Mexico

Matthew Whiting, Ph.D.

Aarron Willingham, Ph.D.****
Affymetrix
Santa Clara, California

Albert Willis, Ph.D.

Chung-Yi Wu, Ph.D.****
Academia Sinica
The Genomics Research Institute
Taipei, Taiwan

Douglass Wu, Ph.D.
Optimer Pharmaceuticals
San Diego, California

Margarita Wuchrer, Ph.D.****
Merck KgaA
Frankfurt, Germany

Heiko Wurdak, Ph.D.

Jian Xie, Ph.D.

Yue Xu, Ph.D.

Ryu Yamasaki, Ph.D.

Shuyan Yao, Ph.D.****
Sangamo BioScience, Inc.
Richmond, California

Robert Yeh, Ph.D. ****
Siemens
Torrance, California

Yong Sik Yoo, Ph.D.****
Cheil Industries, Inc.
Seoul, Korea

Zhanqian Yu, Ph.D.

Mark Zak, Ph.D.****
Genentech
San Francisco, California

Felix Zelder, Ph.D.****

Huaqiang Zeng, Ph.D.****
National University of Singapore
Singapore

Qisheng Zhang, Ph.D.

Yingchao Zhang, Ph.D.

Yuanxiang Zhao, Ph.D.****
Cellular Dynamics International Inc.
Madison, Wisconsin

Heyue Henry Zhou, Ph.D.

Min Zhou, Ph.D.

Xiuwen Zhu, Ph.D.

Joerg Zimmermann, Ph.D.

Caterina Zoni, Ph.D.

Visiting Investigators

Mohammad Al-Sayah, Ph.D.
American University of Sharjah
Sharjah, United Arab Emirates

Luda Bazhenova, Ph.D.****
University of California
San Diego, California

Sheila Fleming, Ph.D.****
University of California
Los Angeles, California

Masakazu Fujio, Ph.D.
Mitsubishi Pharma Corporation
Yokohama, Japan

Luigi Gomez Paloma, Ph.D.****
University di Salerno
Fisciano, Italy

Andrew S. Grant, Ph.D.****
Mount Allison University
Sackville, New Brunswick, Canada

Yoshiyuki Hari, Ph.D.
Nagoya City University
Nagoya, Japan

Akira Ino, Ph.D.
Shionogi & Co., LTD.
Osaka, Japan

Lisa Landino, Ph.D.
College of William and Mary
Williamsburg, Virginia

Jason Moss, Ph.D.****
PDL BioPharma, Inc.
Fremont, California

Poul Nielsen, Ph.D.
University of Southern Denmark
Odense, Denmark

Manuela Rodriguez, Ph.D.****
University di Salerno
Fisciano, Italy

Masaaki Sawa, Ph.D. ****
Dainippon Pharmaceuticals Co., Ltd
Osaka, Japan

Masakazu Sugiyama, Ph.D.
Ajinomoto Co., Inc.
Kawasaki-Shi, Japan

Shin-Ichi Takanashi, Ph.D.****

Erich Uffelman, Ph.D.****
Washington and Lee University
Lexington, Virginia

Makoto Yamashita, Ph.D.****
Takeda Chemical Industries, Ltd.
Osaka, Japan


SCIENTIFIC ASSOCIATES


Jon Ashley

Gina Dendle

Suresh Mahajan, Ph.D.

* Joint appointment in The Skaggs Institute for Chemical Biology
** Joint appointments in the Skaggs Institute for Chemical Biology and the Department of Immunology
*** Joint appointments in The Skaggs Institute for Chemical Biology and the Department of Molecular Biology
**** Appointment completed; new location shown
***** Appointment completed

 


Coiled and extended sodium dodecyl sulfate conformations in the water-soluble cavitand. Nuclear magnetic resonance evidence supports the "strained" structure in which 8 carbon atoms adopt a coiled conformation to maximize interaction with the host. Artwork was done by Michael P. Schramm, Ph.D., The Skaggs Institute for Chemical Biology.