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Scientific Report 2006


Cell Biology





Chairman's Overview

Staff


Sandra L. Schmid, Ph.D.*
Professor and Chairman

Francisco Asturias, Ph.D.**
Associate Professor

William E. Balch, Ph.D.*
Professor

Kristin Baldwin, Ph.D.***
Assistant Professor

Bridget Carragher, Ph.D.**
Associate Professor

Benjamin Cravatt, Ph.D.****
Professor
Director, Helen L. Dorris Child & Adolescent Neuro-Psychiatric Disorder Institute

Gaudenz Danuser , Ph.D.**
Associate Professor

Philip E. Dawson, Ph.D.*****
Associate Professor

Velia Fowler, Ph.D.**
Professor

Martin Friedlander, M.D., Ph.D.
Professor

Larry R. Gerace, Ph.D.*
Professor

Shelley Halpain, Ph.D.***
Associate Professor

Natasha Kralli, Ph.D.
Associate Professor

Peter Kuhn, Ph.D.**
Associate Professor

David Loskutoff, Ph.D.
Professor Emeritus

Mari Manchester, Ph.D.**
Associate Professor

Stephen P. Mayfield, Ph.D.*****
Professor
Associate Dean of Graduate Studies

Mark Mayford, Ph.D.***
Associate Professor

Lindsey Miles, Ph.D.
Associate Professor

Ronald A. Milligan, Ph.D.**
Professor
Director, Center for Integrative Biosciences

Ulrich Müller***
Professor

Ardem Patapoutian, Ph.D.
Associate Professor

Clinton Potter, B.S.**
Associate Professor

James Quigley, Ph.D.
Professor

Lisa Stowers, Ph.D.††
Assistant Professor

Heidi Stuhlmann, Ph.D.
Associate Professor

Kevin F. Sullivan, Ph.D.†††
University of Ireland
Galway, Ireland

Peter N.T. Unwin, Ph.D.**
Professor

Clare Waterman-Storer, Ph.D.**
Associate Professor

Elizabeth Winzeler, Ph.D.
Associate Professor

John R. Yates III, Ph.D.
Professor

Mark J. Yeager, M.D., Ph.D.
Professor

Adjunct Appointments


Alan Bell, B.S.C.S.
Xerox Palo Alto Research Center
Palo Alto, California

Richard Bruce, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Douglas Curry, B.S. (E.E.C.S.)
Xerox Palo Alto Research Center
Palo Alto, California

Bertil Daneholt, M.D.
Karolinska Institutet
Stockholm, Sweden

Scott Elrod, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Mark Ginsberg, M.D.
University of California
San Diego, California

David Goldberg, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Xiaohua Gong, Ph.D.
University of California
Berkeley, California

Klaus Hahn, Ph.D.
University of North Carolina
Chapel Hill, North Carolina

Eric Peeters, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Staff Scientists


Michael Bracey, Ph.D.

Anchi Cheng, Ph.D.

Elena Deryugina, Ph.D.

Robert Fischer, Ph.D.

Elizabeth Wilson, Ph.D.

Senior Research Associates


Brian Adair, Ph.D.

Barbara Calabrese, Ph.D.

Mark Daniels, Ph.D.

Jeremiah Joseph, Ph.D.

Edward Korzus, Ph.D.†††
University of California
Riverside, California

Matthew Ritter, Ph.D.

Martin Schwander, Ph.D.

Gina Story, Ph.D.†††
Washington University
St. Louis, Missouri

Defne Yarar, Ph.D.

Andries Zijlstra, Ph.D.

Research Associates


Jessica Alexander, Ph.D.

Geza Ambrus-Aikelin, Ph.D.

Veronica Ardi, Ph.D.

Angelique Aschrafi, Ph.D.††††

Andrea Bacconi, Ph.D.

Hongdong Bai, Ph.D.

Kent Baker, Ph.D.

Claudia Barros, Ph.D.

Maria Beligni, Ph.D.

Richard Belvindrah, Ph.D.

Edward Brignole III, Ph.D.

Florence Brunel, Ph.D.

Anja Bubeck, Ph.D.†††
Gen-Probe, Inc.
San Diego, California

Gang Cai, Ph.D.

Gregory Cantin, Ph.D.

Eric Carlson, Ph.D.

Aurelia Cassany, Ph.D.

Yuriy Chaban, Ph.D.

Pablo Chamero, Ph.D.

Emily Chen, Ph.D.

Ihsiung Chen, Ph.D.†††
CODA Genomics
Laguna Hills, California

Yei Hua Chen, Ph.D.

Charmian Cher, Ph.D.

Smita Chitnis, Ph.D.

Esther Choi, Ph.D.

Parag Chowdhury, Ph.D.

Jill Chrencik, Ph.D.

Michael Churchill, Ph.D.

Francesco Conti, Ph.D.

Judith Coppinger, Ph.D.

Kaustuv Datta, Ph.D.

Leif Dehmelt, Ph.D.

Ajay Dhaka, Ph.D.

Anouk Dirksen, Ph.D.

Meng-Qui Dong, Ph.D.

Michael Dorrell, Ph.D.

Kelly A. Dryden, Ph.D.

Jerome Dupuy, Ph.D.Anna Durrans, Ph.D.

Samer Eid, Ph.D.†††
Merck Research Laboratories, Neuroscience Drug Discovery
West Point, Pennsylvania

Michael Fitch, Ph.D.†††
Tanabe Research Laboratories U.S.A.
San Diego, California

Santos Franco, Ph.D.

Margaret Gardel, Ph.D.

Maria Gonzalez, Ph.D.†††
Rincon Pharmaceuticals
La Jolla, California

Jorg Grandl, Ph.D.

Nicolas Grillet, Ph.D.

Cemal Gurkan, Ph.D.††††

Johannes Hewel, Ph.D.

Michael Hock, Ph.D.

Ke Hu, Ph.D.

Michael Huber, Ph.D.

Darren Hutt, Ph.D.

Eric Hwang, Ph.D.

Khuloud Jaqaman, Ph.D.

Anass Jawhari, Ph.D.††††

Lin Ji, Ph.D.

Nobutaka Kato, Ph.D.

Claire Kidgell, Ph.D.††††

Katsuhiro Kita, Ph.D.

Kevin Koehntop, Ph.D.

Jenny Kohler, Ph.D.

Atanas Koulov, Ph.D.

Paul LaPointe, Ph.D.

Nicole Lazarus, Ph.D.

Donmienne Leung, Ph.D.†††
Applied Molecular Evolution
San Diego, California

John Lewis, Ph.D.†††
Dalhousie University
Halifax, Nova Scotia, Canada

Lujian Liao, Ph.D.

Maria Lillo, Ph.D.†††
University of Salamanca
Salamanca, Spain

Jennifer Lin, Ph.D.

Ryan Littlefield, Ph.D.†††
University of Washington
Seattle, Washington

Dinah Loerke, Ph.D.

Darren Logan, Ph.D.

Bingen Lu, Ph.D.

Matthias Machacek, Ph.D.

Kalotina Machini, Ph.D.

Mark Madsen, Ph.D.

Valentina Marchetti, Ph.D.

Julia Marin-Navarro, Ph.D.

Michael Matho, Ph.D.

Naoki Matsuo, Ph.D.

Daniel McClatchy, Ph.D.

Caroline McKeown, Ph.D.

Marcel Mettlen, Ph.D.

Helena Mira, Ph.D.

Jennifer Mitchell, Ph.D.

Machiko Muto, Ph.D.

Andromeda Nauli, Ph.D.

Jacobus Neels, Ph.D.

Sherry Niessen, Ph.D.

Silvia Ortega-Gutierrez, Ph.D.

Lesley Page, Ph.D.

Ana Maria Pasaperi-Limon, Ph.D.

Olivier Pertz, Ph.D.†††
University of California
San Diego, California

Barbie Pornillos, Ph.D.

Anita Pottekat, Ph.D.

Judith Prieto, Ph.D.

Natalie Prigozhina, Ph.D.†††
Vala Sciences, Inc.
La Jolla, California

Thomas Pucadyil, Ph.D.

Rajesh Ramachandran, Ph.D.

Vandana Ramachandran, Ph.D.

Abbas Razvi, Ph.D.

Leon Reijmers, Ph.D.

Anna Reynolds, Ph.D.

Edwin Romijn, Ph.D.†††
Philips Scientific Equipment Division
Eindhoven, the Netherlands

Cristian Ruse, Ph.D.

Mohsen Sabouri-Ghomi, Ph.D.

Alan Saghatelian, Ph.D.†††
Harvard University
Cambridge, Massachusetts

Kumar Saikatendu, Ph.D.

Tomoyo Sakata, Ph.D.

Cleo Salisbury, Ph.D.

Ian Schneider, Ph.D.

Christina Schroeder, Ph.D.

Stephan Sieber, Ph.D.†††
Ludwig-Maximilians University
Munich, Germany

Pratik Singh, Ph.D.

Scott Stagg, Ph.D.

Mark Surka, Ph.D.

Patricia Szainer, Ph.D.

Claire Tiraby Nguyen, Ph.D.

Tuija Uusitalo, Ph.D.†††
University of Helsinki
Helsinki, Finland

Valerie Uzzell, Ph.D.

John Venable, Ph.D.

Josep Villena, Ph.D.

Xiaodong Wang, Ph.D.†††
Medical University of Ohio
Toledo, Ohio

Kari Bradtke Weber, Ph.D.

Eranthie Weerapana, Ph.D.

BinQing Wei, Ph.D.

Scott Westenberger, Ph.D.

Ann Wheeler, Ph.D.

Torsten Wittmann, Ph.D.†††
University of San Francisco
San Francisco, California

James Wohlschlegel, Ph.D.

Catherine Wong, Ph.D.

Aaron Wright, Ph.D.

Lihua Wu, Ph.D.†††
Department of Immunology
Scripps Research

Ge Yang, Ph.D.

Masahiro Yasuda, Ph.D.†††
University of Michigan
Ann Arbor, Michigan

Rie Yasuda, Ph.D.†††
Osaka University
Osaka, Japan

Zhongmin Zou, Ph.D.†††
Institute of Combined Injury of PLA, Third Military Medical University
Chongqing, P.R. China

Scientific Associates


Hilda Edith Aguilar de Diaz, M.D.

Alexei Brooun, Ph.D.

Claire Delahunty, Ph.D.

Mohammed El-Kalay, Ph.D.

Tinglu Guan, Ph.D.

Anand Kolatkar, Ph.D.

* Joint appointment in the Department of Molecular Biology
** Joint appointment in the Center for Integrative Molecular Biosciences
*** Joint appointment in the Institute for Childhood and Neglected Diseases
**** Joint appointments in the Department of Chemistry, the Skaggs Institute for Chemical Biology, and the Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute
***** Joint appointment in the Skaggs Institute for Chemical Biology
Joint appointments in the Institute for Childhood and Neglected Diseases and the Genomics Institute of the Novartis Research Foundation
†† Joint appointments in the Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute
††† Appointment completed; new location shown
†††† Appointment completed

 


Electron cryomicroscopy and single-particle analysis were used to determine the 30-Å structure of the self-assembling coat protein complex-II cage nanoparticle. Shown are the 2-fold (bottom), 3-fold (middle), and 4-fold (top) fold symmetry axes of the biologically unprecedented cuboctahedron structure responsible for directing cargo selection and membrane curvature during endoplasmic reticulum vesicle budding. Reprinted from Stagg, S.M., Gurkan, C., Fowler, D.M., LaPointe, P., Foss, T.R., Potter, C.S., Carragher, B., Balch, W.E. Structure of the Sec13/31 COPII coat cage. Nature 439:234, 2006. This work is a collaboration between the laboratories of William Balch, Ph.D., Bridget Carragher, Ph.D, and Clinton Potter, B.S., at the National Resource for Automated Molecular Microscopy.