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Scientific Report 2006


Scripps Florida



Biochemistry




Chairman's Overview


Staff


Steve A. Kay, Ph.D.*
Professor and Chairman

Alessandra Cervino, Ph.D.**
Assistant Professor

Nicholas Gekakis, Ph.D. ***
Assistant Professor

Patrick R. Griffin, Ph.D.**
Professor

Tomothy J. Jegla, Ph.D. ***
Assistant Professor

Claudio A.P. Joazeiro, Ph.D.***
Assistant Professor

Paul J. Kenny, Ph.D.
Assistant Professor

Malcolm A. Leissring, Ph.D.
Assistant Professor

Phillip LoGrasso, Ph.D.**
Associate Professor

Howard T. Petrie, Ph.D.
Professor

Mathew T. Pletcher, Ph.D.**
Assistant Professor

William R. Roush, Ph.D.****
Professor
Associate Dean, Kellogg School of Science and Technology, Florida

Thomas Schultz, Ph.D.***
Assistant Professor of Biochemistry

James Tam, Ph.D.
Professor

Claes Wahlestedt, M.D., Ph.D.**
Professor

Staff Scientists


Michael J. Chalmers, Ph.D.

Takato Imaizumi, Ph.D.***

Ling Li, Ph.D.

Yi An Lu, Ph.D.

Qitao Yu, Ph.D.

Jiu Xiang Zhao, Ph.D.

Quansheng Zhou, Ph.D.

Research Associates


Hedieh Badie, Ph.D.***

Antoine Baudry, Ph.D.***

Mario Bengston, Ph.D.***

Ghislain Breton, Ph.D.***

Darren Bykowski, Ph.D.

Ning Chen, Ph.D.***

Jessie Chu, Ph.D.***

Sonead Clancy, Ph.D.***

Kristin Clarke, Ph.D.

Etzer Darout, Ph.D.

Amy C. DeBaillie, Ph.D.

Joshua R. Dunetz, Ph.D.

Eva Farré, Ph.D.***

Kerim Gattas-Asfura, Ph.D.

Elizabeth Hamilton, Ph.D.***

Masaki Handa, Ph.D.

Samuel Hazen, Ph.D.***

Anne Helfer, Ph.D.***

Tamara Hopkins, Ph.D.

Rebecca J. Kocerha, Ph.D.

Warren Lewis, Ph.D.***

Fangzheng Li, Ph.D.

Wei Li, Ph.D.***

C-Y Liu, Ph.D.***

Julien Mamet, Ph.D.***

Brooke H. Miller, Ph.D.

William Mwangi, Ph.D.

Hiroshi Nakase, Ph.D.

Michael H. Ober, Ph.D.

Alessia Para, Ph.D.***

Jeffery Pitman, Ph.D.***

Swati Prasad, Ph.D.

Jose Pruneda-Paz***

Troy D. Ryba, Ph.D.

Achim M. Sorg, Ph.D.

Sahba Tabrizifard, Ph.D.

Mariola Tortosa, Ph.D.

Hein Tran, Ph.D.***

Axel Ulbrich, Ph.D.***

Oliver Umland, Ph.D.

Matthew Wheeler, Ph.D.***

Jason, Willkes, Ph.D.***

Amie L. Williams, Ph.D.

Eric Zhang, Ph.D.***

Visiting Investigator


David Welsh, M.D., Ph.D.***
Assistant Professor
Department of Psychiatry
University of California, San Diego

* Joint appointments in the Department of Cell Biology and the Institute for Childhood and Neglected Diseases
** Joint appointment in the Translational Research Institute
*** California campus
**** Joint appointments in the Translational Research Institute and the Department of Chemistry

 

A combination of structural approaches, including x-ray crystallography, in the laboratory of K.W. Nettles, Ph.D., and amide hydrogen-deuterium exchange mass spectrometry, in the laboratory of P.R. Griffin, Ph.D., were used to dissect how diverse ligands control the allosteric function of the nuclear receptor ligand-binding domain. The ligand-binding domain of the estrogen receptor is shown bound to an estrogen derivative, trifluoromethylphenylvinyl-estradiol.




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