Scientific Report 2005

Neurobiology

Chairman's Overview

Staff

Gerald M. Edelman, M.D., Ph.D.*
Professor and Chairman

Kathryn L. Crossin, Ph.D.
Associate Professor

Bruce A. Cunningham, Ph.D.
Professor

Ralph Greenspan, Ph.D.
Adjunct Professor

Frederick S. Jones, Ph.D.
Associate Professor

Vincent P. Mauro, Ph.D.
Associate Professor

Robyn Meech, Ph.D.
Assistant Professor

Peter W. Vanderklish, Ph.D.
Assistant Professor

Staff Scientist

Wei Zhou, Ph.D.

Senior Research Associates

Annette R. Atkins, Ph.D.
Stephen A. Chappell, Ph.D.

Research Associates

S. Armaz Aschrafi, Ph.D.
John Dresios, Ph.D.
Olivier Harismendy, Ph.D.
Dora Chin Yen Koh, Ph.D.

George W. Rogers, Jr., Ph.D.**
NexBio, Inc.
San Diego, California

Fiona Smart, Ph.D.***

Tracy A. Stevens, Ph.D.**
The Burnham Institute
La Jolla, California

Marina Tsatmali, Ph.D.

Visiting Investigators

Sigeng Chen, Ph.D.
The Neurosciences Institute
San Diego, California

David Edelman, Ph.D.
The Neurosciences Institute
San Diego, California

Geoffrey Owens
The Neurosciences Institute
San Diego, California

* Joint appointment in The Skaggs Institute for Chemical Biology
** Appointment completed; new location shown
*** Appointment completed

Schematic representation of a mouse-yeast hybrid 18S rRNA. Yeast expressing the hybrid rRNA were used to demonstrate an mRNA-rRNA base-pairing interaction between a mouse translational enhancer element from the Gtx-homeodomain mRNA and a complementary sequence contained within the 18S rRNA of 40S ribosomal subunits. This work was performed by John Dresios, Stephen Chappell, and Wei Zhou in the laboratory of Vincent P. Mauro, Ph.D. The mouse 18S rRNA is depicted as a black line, and the yeast rRNA is indicated as a white line. The hybrid rRNA contains both mouse and yeast sequences and is depicted as a black-and-white line. The secondary structures were adapted from those obtained on the Comparative RNA Web Site (http://www.rna.icmb.utexas.edu/) of Robin Gutell, Ph.D., University of Texas. The artwork was done by Dr. Mauro.