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Scientific Report 2005


Chemistry





Chairman's Overview

STAFF

K.C. Nicolaou, Ph.D.*
Chairman
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry

Phil Baran, Ph.D.
Assistant Professor

Dale L. Boger, Ph.D.*
Richard and Alice Cramer Professor of Chemistry

Bruce Clapham, Ph.D.**
Abbott Laboratories
Abbott Park, Illinois

Tobin Dickerson, Ph.D.
Assistant Professor

Sheng Ding, Ph.D.
Assistant Professor

Albert Eschenmoser, Ph.D.*
Professor

M.G. Finn, Ph.D.*
Associate Professor

Valery Fokin, Ph.D.
Assistant Professor

M. Reza Ghadiri, Ph.D.*
Professor

Inkyu Hwang, Ph.D.
Assistant Professor

Kim D. Janda, Ph.D.***
Professor
Ely R. Callaway, Jr., Chair in Chemistry

Jeffery W. Kelly, Ph.D.*
Vice President, Academic Affairs
Dean, Kellogg School of Science and Technology
Lita Annenberg Hazen Professor of Chemistry

Hartmuth Kolb, Ph.D.**
University of California
Los Angeles, California

Ramanarayanan Krishnamurthy, Ph.D.
Associate Professor

Richard A. Lerner, M.D.****
President, Scripps Research
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Masayuki Matsushita, Ph.D.
Assistant Professor

Evan Powers, Ph.D.
Assistant Professor

Julius Rebek, Jr., Ph.D.*
Professor
Director, The Skaggs Institute for Chemical Biology

Ed Roberts, Ph.D.
Professor

Floyd E. Romesberg, Ph.D.
Assistant Professor

Peter G. Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
W.M. Keck Professor of Chemistry

Anita Wentworth, Ph.D.
Assistant Professor

Paul Wentworth, Jr., Ph.D.
Professor

Peter Wirsching, Ph.D.*****

Chi-Huey Wong, Ph.D.*
Ernest W. Hahn Professor and Chair in Chemistry

Andrew Bin Zhou, Ph.D.
Assistant Professor

Staff Scientists

Byeong D. Song, Ph.D.

Lubica Supekova, Ph.D.

Instrumentation/Service Facilities

Raj K. Chadha, Ph.D.
Director, X-Ray Crystallography Facility

Dee H. Huang, Ph.D.
Director, Nuclear Magnetic Resonance Facility

Gary E. Siuzdak, Ph.D.
Director, Mass Spectrometry Facility

senior Research Associates

Ashraf Brik, Ph.D.

Yanping Chen, Ph.D.

Tobin Dickerson, Ph.D.

Michael Meijler, Ph.D.

Research Associates

Ramzey Abujarour, Ph.D.Jung-Mo Ahn, Ph.D.**
University of Texas
Dallas, Texas

Dariush Ajami, Ph.D.

Lital Alfonta, Ph.D.

Toru Amaya, Ph.D.**
Osaka University
Osaka, Japan

Rajesh Ambasudhan, Ph.D.

Narendra B. Ambhaikar, Ph.D.

Stellios Arseniyadis, Ph.D.

Gonen Ashkenasy, Ph.D.

Nurit Ashkenasy, Ph.D.

Masato Atsumi, Ph.D.

Elizabeth Barrett, Ph.D.

Christoph Behrens, Ph.D.

Clay Bennett, Ph.D.

Michael Best, Ph.D.**
University of Tennessee
Knoxville, Tennessee

Jan Bieschke, Ph.D.

Babu Boga, Ph.D.

Anthony Boitano, Ph.D.

Brant Boren, Ph.D.

Daryl Bosco, Ph.D.

Mohua Bose, Ph.D.**
Stanford University
Stanford, California

Patrick Braun, Ph.D.**
University of Minnesota
Minneapolis, Minnesota

Andy Brogan, Ph.D.

Adrian Brunkhorst, Ph.D.

Paul Bulger, Ph.D.

Kevin Bunker, Ph.D.

Mark Bushey, Ph.D.

Sara Butterfield, Ph.D.

Edelmira Cabezas, Ph.D.**
Intel Corp.
Santa Clara, California

Alexandre Carella, Ph.D.

Giacomo Carenzi, Ph.D.**
Nerviano Medical Sciences
Nerviana, Italy

Michael Cassidy, Ph.D.

Aileen Chang, Ph.D.**
Kresge Library
Scripps Research

Shuo Chen, Ph.D.

Heng Cheng, Ph.D.**
FibroGen, Inc.
South San Francisco, California

Jodie Chin, Ph.D.

Charles Cho, Ph.D.

Younggi Choi, Ph.D.**
Boehringer Ingelheim Pharmaceuticals, Inc.
Ridgefield, Connecticut

Youhoon Chong, Ph.D.**
Konkuk University
Seoul, Korea

Benoit Colasson, Ph.D.**
University of Pavia
Pavia, Italy

Kevin Cole, Ph.D.

Antonella Converso, Ph.D.

Jeromy Cottell, Ph.D.

James Crawford, Ph.D.

Matthew Cremeens, Ph.D.

Ashton Cropp, Ph.D.**
University of Maryland
College Park, Maryland

Francesco De Riccardis, Ph.D.**
Università di Salerno
Baronissi (SA), Italy

Konstantinos Dellios, Ph.D.**
Chemistry Laboratory of the Government
Larisa, Greece

David Diaz-Diaz, Ph.D.

Christine Dierks, Ph.D.

Ross Denton, Ph.D.

Romyr Dominque, Ph.D.**
Hoffmann-La Roche, Inc.
Nutley, New Jersey

Song Byeong Doo, Ph.D.

Wu Du, Ph.D.**
Merck Research Laboratories
Rahway, New Jersey

David Edmonds, Ph.D.

Greg Elliott, Ph.D.

Nile Emre, Ph.D.

Simon Eppacher, Ph.D.

Lisa Eubanks, Ph.D.

Raffaella Faraoni, Ph.D.

Laura Flatauer, Ph.D.

James Fletcher, Ph.D.**
Creighton University
Omaha, Nebraska

Rebecca Fraser, Ph.D.

Graeme Freestone, Ph.D.

Yanwen Fu, Ph.D.

Jim Fuchs, Ph.D.

Carmen Galan, Ph.D.**
Massachusetts Institute of Technology
Cambridge, Massachusetts

Jianmin Gao, Ph.D.

Mu-yun Gao, Ph.D.

Nathan Gianneschi, Ph.D.

Arnaud Gissot, Ph.D.**
Université Victor Segalen Bordeaux II
Bordeaux, France

Rajesh Grover, Ph.D.

Shen Gu, Ph.D.*****

Sayam Sen Gupta, Ph.D.

Clemens Haas, Ph.D.

Young Wan Ham, Ph.D.**
Molecular Therapeutics, Inc.
Ann Arbor, Michigan

Akiyuki Hamasaki, Ph.D.

Wooseok Han, Ph.D.

Christophe Hardouin, Ph.D.**
Oril Industry, SA
Bolbec, France

Frank Hauke, Ph.D.

Mark Hixon, Ph.D.

Rebecca Holmberg, Ph.D.**
Ionian Technologies, Inc.
Upland, California

Sukwon Hong, Ph.D.

Wang Hong, Ph.D.Zhangyong Hong, Ph.D.

Richard Hookey, Ph.D.

Daniel Horne, Ph.D.

Che-Chang (Jeff) Hsu, Ph.D.**
EMD Biosciences, Inc.
San Diego, California

Tsui-Ling Hsu, Ph.D.

Qihong Huang, Ph.D.**
Wistar Institute
Philadelphia, Pennsylvania

Zheng-Zheng Huang, Ph.D.

Amy Hurshman, Ph.D.

Der-Ren Hwang, , Ph.D.

Giltae Hwang, Ph.D.

Hayato Ishikawa, Ph.D.

Tetsuo Iwasawa, Ph.D.

Michael Jahnz, Ph.D.

Wei Jin, Ph.D.

Florian Kaiser*****

Michael Kelso, Ph.D.

Gyungyoun Kim, Ph.D.

Sang Jick Kim, Ph.D.**
Korean Research Institute of Bioscience and Biotechnology
Taejon, Korea

Yoonkyung Kim, Ph.D.*****

Theocharis Koftis**
Pharmathen Pharmaceuticals
Thessaloniki, Greece

Ravinder Reddy Kondreddi, Ph.D.

Antoni Krasinski, Ph.D.**
ChemoCentryx, Inc.
Mountain View, California

Andreas Krebs, Ph.D.**
BASF
Ludwigshafen, Germany

Grover Rajesh Kumar, Ph.D.

Jane Kuzelka, Ph.D.

Carolina Martinez Lamenca, Ph.D.

Eltepu Laxman, Ph.D.**
MediVas, LLC
San Diego, California

Byong Se Lee, Ph.D.**
Asian Medical Center
Seoul, Korea

Hing Ken Lee, Ph.D.*****

Jinq-Chyi Lee, Ph.D.

Jongkook Lee, Ph.D.

Ki-Bum Lee, Ph.D.

Lac Lee, Ph.D**
Novartis Institutes for Biomedical Research Inc.
Cambridge, Massachusetts

Sang Hyeup Lee, Ph.D.**
Korean Research Institute of Bioscience and Biotechnology
Taejon, Korea

Sanghyup Lee, Ph.D.

Chunmei Li, Ph.D. **
Stephen F. Austin State University
Nacogdoches, Texas

Ke Li, Ph.D.

Yongkai Li, Ph.D.**
Ligand Pharmaceuticals, Inc.
San Diego, California

Antonietta M. Lillo, Ph.D.**
Los Alamos National Laboratory
Los Alamos, New Mexico

Yeon-Hee Lim, Ph.D.Tao Tao Ling**
Nereus Pharmaceuticals, Inc.
San Diego, California

Jun Liu, Ph.D.

Junjie Liu, Ph.D.**
AMSI
San Diego, California

Lei Liu, Ph.D.

Wenshe Liu, Ph.D.

Ying (Cindy) Liu, Ph.D.

Dimitrios Lizos, Ph.D.

Jon Loren, Ph.D.**
Ligand Pharmaceuticals, Inc.
San Diego, California

Hendrick Luesch, Ph.D.**
University of Florida
Gainesville, Florida

Hongzheng (Eric) Ma, Ph.D.

Sunil Mandal, Ph.D.**
Acenta Discovery, Inc.
Tucson, Arizona

Nello Mainolfi, Ph.D.

Roman Manetsch, Ph.D.

Enrique Mann, Ph.D.

Felix Marr, Ph.D.

Shigeo Matsuda, Ph.D.

Laura McAllister, Ph.D.

Kathleen McKenzie, Ph.D.

Andrew McPherson, Ph.D.**
TargeGen, Inc.
San Diego, California

Edoardo Menozzi, Ph.D.

Sergio Meth, Ph.D.**
Federal University of Rio de Janeiro
Rio de Janeiro, Brazil

Robert Milburn, Ph.D.

Kyung-Hoon Min, Ph.D.

Christos A. Mitsos, Ph.D.

Gopi Kumar Mittapalli, Ph.D.

Lionel Moisan, Ph.D.

Ann Montero, Ph.D.

Yasutaka Morita, Ph.D.**
Kinki University
Fukuoka, Japan

Mridul Mukherji, Ph.D.

Oscar Munoz, Ph.D.**
Universidad Veracruzana
Veracruz, México

Andrew Myles, Ph.D.

Joonwoo Nam, Ph.D.

Sridhar Narayan, Ph.D.

Daniel Nicoletti, Ph.D.

Alain Noncovich, Ph.D.

Yasuo Norikane, Ph.D.

Mehdi Numa, Ph.D.

Barun Okram, Ph.D.

Hideki Onagi, Ph.D.*****

Yazmin Osornio, Ph.D.

Charles Papageorgiou, Ph.D.

Laxman Pasunoori, Ph.D.

Goran Petrovic, Ph.D.

Steven Pfeiffer, Ph.D.**
Gilead
Foster City, California

Jared Piper, Ph.D.

Suresh Pitram, Ph.D.Tülay Polat, Ph.D.

Sreenivas Punna, Ph.D.

Longwu Qi, Ph.D.**
Prolexys Pharmaceuticals, Inc.
Salt Lake City, Utah

Daniela Radu, Ph.D.

Nicole Rahe, Ph.D.

Shai Rahimipour, Ph.D.

Dalit Rechavi-Robinson, Ph.D.

Surakattula Murali Mohan Reddy, Ph.D.

Yosup Rew, Ph.D.**
Amgen, Inc.
Thousand Oaks, California

Sebastien Richeter, Ph.D.**
Université Montpellier II
Montpellier, France

Stefanie Roeper, Ph.D.

F. Anthony Romero, Ph.D.

Youngha Ryu, Ph.D.

Riccardo Salvio, Ph.D.

Pradip Sasmal**
Dr. Reddy’s Laboratories, Ltd.
Hyderabad, India

Alessandro Scarso, Ph.D.**
Università Cà Foscari di Venezia
Venice, Italy

Patrick Schanen, Ph.D.

Stefan Schiller, Ph.D.

Daniel Schlawe, Ph.D.**
Syncom BV
Groningen, the Netherlands

Michael Schramm, Ph.D.

Akira Shigenaga, Ph.D.**
Tokushima University
Tokushima, Japan

Dongwoo Shin, Ph.D.**
Samsung
Seoul, Korea

Junhwa Shin, Ph.D.

Sebastian Steiniger, Ph.D.

Shula Stokols, Ph.D.

Ji Young Suk, Ph.D.

Daniel Summerer, Ph.D.

Xiowen Sun**
Lanzhou University
Lanzhou, China

Leo Takaoka, Ph.D.

Wenjun Tang**
Boehringer Ingelheim Pharmaceuticals, Inc.
Ridgefield, Connecticut

Eric Tippmann, Ph.D.

Laurent Trembleau, Ph.D.**
University of Aberdeen
Aberdeen, Scotland

Meng-Lin Tsao, Ph.D.

Craig Turner, Ph.D.

Jim Turner, Ph.D.

Elke Ullrich, Ph.D.**
Syncom BV
Groningen, the Netherlands

Jan Van Maarseveen,**
Universiteit van Amsterdam
Amsterdam, the Netherlands

Juraj Velcicky, Ph.D.

David Vodak, Ph.D.**
Bend Research, Inc.
Bend, Oregon

Alexandro Volonterio, Ph.D.

Jiangyun Wang, Ph.D.

Xiaolong Wang, Ph.D.

Gregory Watt, Ph.D.**
Nature Chemical Biology
Cambridge, Massachusetts

Lisa Whalen, Ph.D.

Matthew Whiting, Ph.D.

Aarron Willingham, Ph.D.

R. Luke Wiseman, Ph.D.

Chung-Yi Wu, Ph.D.

Margarita Wuchrer, Ph.D.

Hui Xiong, Ph.D.**
University of Pennsylvania
Philadelphia, Pennsylvania

Wen Xiong, Ph.D.

Masamichi Yamanaka, Ph.D.**
Shizuoka University
Shizuoka, Japan

Ryu Yamasaki, Ph.D.

Shuyuan Yao, Ph.D.

Robert M. Yeh, Ph.D.

Yong Sik Yoo, Ph.D.

Ninghui Yu, Ph.D.**
Serono, Inc.
Rockland, Massachusetts

Zhanqian Yu, Ph.D.

Dawei Yue, Ph.D.

Felix Zelder, Ph.D.

Huaqiang Zeng, Ph.D.

Qing-Hai Zhang, Ph.D.**
Department of Molecular Biology
Scripps Research

Qisheng Zhang, Ph.D.

Yuanxiang Zhao, Ph.D.

LianXing Zheng, Ph.D.**
Models of Disease Center
Cambridge, Massachusetts

Xiuwen Zhu, Ph.D.

Joerg Zimmermann, Ph.D.

Visiting Investigators

Luda Bazhenova, M.D.
Moores Cancer Center
La Jolla, California

Masakazu Fujio, Ph.D.
Mitsubishi Pharma Corporation
Yokohama, Japan

Trond Vidar Hansen, Ph.D.**
University of Oslo
Oslo, Norway

Bumpei Hatano, Ph.D.**
Yamagata University
Yonezawa, Japan

Tomoyasu Hirose, Ph.D.**
The Kitasato Institute
Tokyo, Japan

Jiyong Hong, Ph.D.
Genomics Institute of the Novartis Research Foundation
San Diego, California

Jiayu Liao, Ph.D.
Genomics Institute of the Novartis Research Foundation
San Diego, California

Jie Li, Ph,D.*****

Masayuki Oda, Ph.D.
Kyoto Prefectural University
Kyoto, Japan

Masaaki Sawa, Ph.D.
Dainippon Pharmaceuticals Co., Ltd.
Osaka, Japan

Masakazu Sugiyama, Ph.D.
Ajinomoto Co., Inc.
Kawasaki-shi, Japan

Shin-Ichi Takanashi, Ph.D.
Mitsubishi Pharma Corporation
Osaka, Japan

Makoto Yamashita, Ph.D.
Takeda Chemical Industries, Ltd.
Osaka, Japan

Scientific Associates

Jon Ashley

Maria-Teresa Dendle

Suresh Mahajan, Ph.D.

* Joint appointment in The Skaggs Institute for Chemical Biology
** Appointment completed; new location shown
*** Joint appointments in The Skaggs Institute for Chemical Biology and the Department of Immunology
**** Joint appointments in The Skaggs Institute for Chemical Biology and the Department of Molecular Biology
***** Appointment completed

 


A single rotaxane structure created by threading and capturing a DNA-poly(ethylene glycol) strand inside an α-hemolysin transmembrane pore protein. This supramolecular system constitutes the basis of a research program to design a rapid pore-mediated single-molecule DNA-sequencing technology. Work done in the laboratory of M. Reza Ghadiri, Ph.D