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Scientific Report 2004


Molecular and Experimental Medicine




Chairman's Overview


Staff


Ernest Beutler, M.D.*
Chairman and Professor
Head, Division of Hematology

Masahiro Aoki, M.D., Ph.D.
Adjunct Assistant Professor

Hiroshi Asahara, M.D., Ph.D.
Assistant Professor

Bernard M. Babior, M.D., Ph.D.
Professor
Head, Division of Biochemistry

Bonno N. Bouma, Ph.D.
Adjunct Professor

Mathew E. Brunson, M.D.
Adjunct Assistant Professor

Joel N. Buxbaum, M.D.
Professor
Head, Division of Research Rheumatology

Carlos J. Carrera, M.D.
Adjunct Assistant Professor

Dennis A. Carson, M.D.
Adjunct Professor

Sergio D. Catz, Ph.D.
Assistant Professor

Francis V. Chisari, M.D.
Professor
Head, Division of Experimental Pathology

Sandra Christiansen, M.D.
Adjunct Associate Professor

Jack Clausen, M.D.
Adjunct Professor

Clifford W. Colwell, Jr., M.D.
Adjunct Professor

Brian R. Copeland, M.D.
Adjunct Assistant Professor

Roger C. Cornell, M.D.
Adjunct Professor

Laura M. Crisa, M.D.
Assistant Professor

John T. Curnutte, M.D., Ph.D.
Adjunct Associate Professor

George L. Dale, Ph.D.
Adjunct Associate Professor

Arthur D. Dawson, M.D.
Adjunct Professor

Albert B. Deisseroth, M.D., Ph.D.
Adjunct Professor

Gregory J. del Zoppo, M.D.**
Associate Professor

Giacomo A. DeLaria, M.D.
Adjunct Associate Professor

Thomas F. Deuel, M.D.
Professor

Ralph B. Dilley, M.D.
Adjunct Professor

Darryl D’Lima, M.D.
Adjunct Assistant Professor

Darlene J. Elias, M.D.
Adjunct Assistant Professor

Brunehilde Felding-Habermann, Ph.D.
Associate Professor

Carlo Ferrari, M.D.
Adjunct Associate Professor

Mitchell H. Friedlaender, M.D.
Adjunct Professor

Jeffrey S. Friedman, M.D., Ph.D.
Assistant Professor

Theodore Friedmann, M.D.
Adjunct Professor

Andrew J. Gale, Ph.D.
Assistant Professor

Roberta A. Gottlieb, M.D.
Associate Professor

John H. Griffin, Ph.D.**
Professor

Andras Gruber, M.D.
Adjunct Assistant Professor

Luca G. Guidotti, D.V.M., Ph.D.
Associate Professor

Anne M. Hanneken, M.D.
Associate Professor

Mary J. Heeb, Ph.D.**
Associate Professor

Paul G. Heyworth, Ph.D.
Adjunct Associate Professor

James A. Hoch, Ph.D.
Professor
Head, Division of Cellular Biology

Frank M. Huennekens, Ph.D.
Professor Emeritus

Alfredo A. Jalowayski, Ph.D.
Adjunct Assistant Professor

Eric F. Johnson, Ph.D.
Professor

Kazuhiro Kakimi, M.D., Ph.D.
Adjunct Assistant Professor

Thomas J. Kipps, M.D., Ph.D.
Adjunct Professor

Lawrence E. Kline, D.O.
Adjunct Associate Professor

James A. Koziol, Ph.D.
Professor
Head, Division of Biomathematics

Daniel F. Kripke, M.D.
Adjunct Professor

Thomas J. Kunicki, Ph.D.**
Associate Professor

Stuart A. Lipton, M.D., Ph.D.
Adjunct Professor

Fu-Tong Liu, Ph.D., M.D.
Adjunct Professor

Martin Lotz, M.D.
Professor
Head, Division of Arthritis Research

Christopher Lee Marsh, M.D.
Adjunct Associate Professor

James R. Mason, M.D.
Adjunct Assistant Professor

David A. Mathison, M.D.
Adjunct Professor

Robert McMillan, M.D.
Professor Emeritus

William E. Miller, M.D.
Adjunct Assistant Professor

Jorge J. Nieva, M.D.
Assistant Professor

Zhixing K. Pan, M.D., Ph.D.
Adjunct Assistant Professor

Anthony J. Pelletier, Ph.D.
Adjunct Assistant Professor

Marta Perego, Ph.D.
Associate Professor

Randolph S. Piotrowicz, Ph.D.***
Bio-Quant, Inc.
San Diego, California

Paul J. Pockros, M.D.
Adjunct Assistant Professor

K. Michael Pollard, Ph.D.
Associate Professor

Giuseppe Remuzzi, M.D.
Adjunct Professor

Michael W. Robertson, Ph.D.
Associate Professor

John S. Romine, M.D.
Adjunct Associate Professor

Zaverio M. Ruggeri, M.D.**
Professor
Head, Division of Experimental Hemostasis and Thrombosis

Robert J. Russo, M.D., Ph.D.
Adjunct Assistant Professor

Enrique Saldivar, M.D., Ph.D.
Adjunct Assistant Professor

Daniel R. Salomon, M.D.
Associate Professor

Alan Saven, M.D.
Adjunct Professor

Nicholas J. Schork, Ph.D.
Adjunct Professor

Alessandro Sette, Ph.D.
Adjunct Professor

Farhad F. Shadan, M.D., Ph.D.
Adjunct Assistant Professor

Alexander R. Shikhman, M.D., Ph.D.
Assistant Professor

Inmaculada Silos-Santiago, M.D., Ph.D.
Adjunct Associate Professor

Gregg J. Silverman, M.D.
Adjunct Associate Professor

Ronald A. Simon, M.D.
Adjunct Professor

Peter J. Sims, M.D., Ph.D.
Professor

Jack C. Sipe, M.D.
Associate Professor

Joseph A. Sorge, M.D.
Adjunct Professor

Donald D. Stevenson, M.D.
Adjunct Professor

Williamson B. Strum, M.D.
Adjunct Assistant Professor

Eng M. Tan, M.D.
Professor

Bruce E. Torbett, Ph.D.
Associate Professor

Constantine Tsoukas, Ph.D.
Adjunct Associate Professor

Susan L. Uprichard, Ph.D.
Assistant Professor

Kottayil I. Varughese, Ph.D.**
Associate Professor

John H. Vaughan, M.D.
Adjunct Professor

Peter K. Vogt, Ph.D.
Professor
Head, Division of Oncovirology

Matthias G. von Herrath, M.D.
Adjunct Associate Professor

Jerry L. Ware, Ph.D.**
Associate Professor

Therese Wiedmer, Ph.D.
Associate Professor

Xiaohua Wu, Ph.D.
Assistant Professor

Takao Yagi, Ph.D.
Associate Professor

John C. Yu, M.D., Ph.D.
Adjunct Associate Professor

Dong-Er Zhang, Ph.D.
Associate Professor

Bruce L. Zuraw, M.D.
Associate Professor

Staff Scientists


Reha Celikel, Ph.D.

Mei-Hui Hsu, Ph.D.

Jennifer L. Johnson, Ph.D.

Klaus Kuhn, Ph.D.

Pauline L. Lee, Ph.D.

Patrizia Marchese, Ph.D.

Tsaiwei Olee, Ph.D.

Brian Savage, Ph.D.

Stefan Wieland, Ph.D.

Akemi Yagi, Ph.D.

Ji Zhao, Ph.D.

Quansheng Zhou, Ph.D.

Senior Research Associates


Hiroshi Deguchi, M.D., Ph.D.

Jane Eddleston, Ph.D.

Sanshiro Hashimoto, M.D.

Fu-Dong Shi, M.D., Ph.D.***
St. Joseph’s Hospital Medical Center
Phoenix, Arizona

Keith Stephenson, Ph.D.

Clement E. Tagoe, Ph.D.Subramanian Yegneswaran, Ph.D.

Research Associates


Cinzia Ambrosi, Ph.D.

Marc E. Arnush, M.D.

Shinichi Asabe, Ph.D.

Erin N. Asleson, Ph.D.

Andreas Bader, Ph.D.

Iris Ben-Efraim, Ph.D.

Cristina Bongiorni, Ph.D.

Kristen E. Bower, Ph.D.

Anita Y. Boyapati, Ph.D.

Katia Maria Cabral, Ph.D.

Maria del Carmen Carles, Ph.D.

David M. Cauvi, Ph.D.

Yunchao Chang, Ph.D.

Huan Yuan Chen, Ph.D.***
University of California
Davis, California

Ling-Yu Chen, M.D.***
Medical College of Ohio
Toledo, Ohio

Emily I. Chen, Ph.D.

Guofeng Cheng, Ph.D.

Stephanie Cherqui, Ph.D.

Takuya Chiba, Ph.D.

Ian D. Dang, Ph.D.

Chinh T. Dao, Ph.D.

Gabriela D.C. Denning, Ph.D.

Alejandra R. Diaz, Ph.D.Astrid M. Doerner, Ph.D.***
Medical College of Ohio
Toledo, Ohio

Anthony S. Don, Ph.D.

Jonathon M. Flanagan, Ph.D.

Tatsuya Fukushima, Ph.D.

Yoshihiro Furuichi, M.D.***
Tokyo Medical University
Tokyo, Japan

Takayuki Furumatsu, M.D., Ph.D.

Asa B. Gustafsson, Ph.D.

Lynn E. Hancock, Ph.D.

Wolf-Achim Hassenpflug, M.D.

Robert Hines, Ph.D.

Koji Hiraoka, M.D., Ph.D.

Chengqun Huang, M.D., Ph.D.

Jaiweon Hwang, Ph.D.

Matteo Iannacone, M.D.

Masanori Isogawa, M.D.

Hao Jiang, Ph.D.

Margaret L. Just, Ph.D.

Eiki Kambe, M.D., Ph.D.***
Nagoya University
Nagoya City, Japan

Sohye Kang, Ph.D.

Mou-Chieh Kao, Ph.D.

Sharookh B. Kapadia, Ph.D.

Kazunobu Kato, M.D., Ph.D.

Alexandra K. Kiemer, Ph.D.

Keun Il Kim, Ph.D.Mu-Yong Kim, Ph.D.***
LG Life Sciences, Ltd.
Daejeon, Korea

Sunil M. Kurian, Ph.D.

Yumi Kurokawa, M.D., Ph.D.

Victoria Kutilek, Ph.D.

Pablo G. Landart, Ph.D.

Xianghong Li, Ph.D.***
Johns Hopkins University
Baltimore, Maryland

Enbo Liu, Ph.D.

M. Isabel Velazquez Lopez, M.D., Ph.D.

Jiann-Kae Luo, Ph.D.

Takuma Mabuchi, M.D., Ph.D.

Florent M. Martin, Ph.D.

Yuri Martina, Ph.D.

Constantino Martinez, Ph.D.

Grazia L. Mendolicchio, Ph.D.

Laurent O. Mosnier, Ph.D.

Debashis Mukhopadhyay, Ph.D.**
University of California
San Diego, California

David J. Mustra, Ph.D.***
National Center for Environmental Research
Washington, DC

Eiko Nakamaru-Ogiso, Ph.D.

Meera Nanjundan, Ph.D.***
M.D. Anderson Cancer Center
Houston, Texas

Sandrine Pacquelet, Ph.D.

Harold P. Pariser, Ph.D.

Viktor M. Paromov, Ph.D.

Natalie M. Pecheniuk, Ph.D.

Luke F. Peterson, Ph.D.

Pablo Perez Pinera, M.D.

Gian Marco Podda, M.D.

A. Venkateshwar Reddy, Ph.D.

Richard M. Reisdorph, Ph.D.

Natalia Reixach, Ph.D.

Kenneth J. Ritchie, Ph.D.***
Ninewells Hospital Medical School
Dundee, Scotland

Michael D. Robek, Ph.D.

Uzen Savas, Ph.D.

Guillaume A. Schoch, Ph.D.

Byoung Boo Seo, Ph.D.

Dennis A. Sheeter, Ph.D.

Jin Shi, Ph.D.

Natalia Sigal, Ph.D.***
DNAX Research Institute
Palo Alto, California

Giovanni Sitia, M.D.***
San Raffaele Scientific Institute
Milan, Italy

Usha Srinivasan, Ph.D.

Alexander M. Szabo, Ph.D.***
MicroIslets, Inc.
San Diego, California

Noboru Taniguchi, M.D.

Mario P. Tschan, Ph.D.

Masanao Tsuda, Ph.D.

Billyana C. Tsvetanova, Ph.D.

Jill M. Waalen, M.D.

Yang Wang, Ph.D.Martin R. Weber, Ph.D.

Michael R. Wester, Ph.D.***
Pfizer Global Research and Development
San Diego, California

Tetsuo Yamashita, Ph.D.

Ming Yan, Ph.D.

Jason K. Yano, Ph.D.

Jinseong Yi, Ph.D.

Guorong Zhang, Ph.D.

Haiyan Zhao, Ph.D.

Jin Zhong, Ph.D.

Weiguo Zou, Ph.D.

Masahiko Zuka, M.D., Ph.D.

Scientific Associates


Fanny E. Almus, Ph.D.

Jose A. Fernandez, Ph.D.

Terri P. Gelbart, B.S., M.T.

Julie M. Ruedi, B.A.

* Joint appointment in The Skaggs Institute for Chemical Biology
** Joint appointment in the Department of Cell Biology
*** Appointment completed; new location shown

Section Cover For The Department Of Molecular And Experimental Medicine: Preliminary electron cryomicroscopy reconstructions of native hepatitis B virions and core particles. Left, Surface-shaded view of the ~50-nm mature virion. Center, Virion cross section showing density layers with the lipid bilayer, core capsid, and internal genome. Right, Surface-shaded view of the ~35-nm immature core. Graphics and data analysis by Kelly Dryden, Ph.D., and Stefan Wieland, Ph.D. Collaboration between laboratories of Mark Yeager, M.D., Department of Cell Biology, and Francis V. Chisari, M.D., Department of Molecular and Experimental Medicine.

 

Preliminary electron cryomicroscopy reconstructions of native hepatitis B virions and core particles. Left, Surface-shaded view of the ~50-nm mature virion. Center, Virion cross section showing density layers with the lipid bilayer, core capsid, and internal genome. Right, Surface-shaded view of the ~35-nm immature core. Graphics and data analysis by Kelly Dryden, Ph.D., and Stefan Wieland, Ph.D. Collaboration between laboratories of Mark Yeager, M.D., Department of Cell Biology, and Francis V. Chisari, M.D., Department of Molecular and Experimental Medicine.