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Scientific Report 2004


Molecular Biology




Chairman's Overview


Staff


Peter E. Wright, Ph.D.*
Professor and Chairman
Cecil H. and Ida M. Green Investigator in Medical Research

Ruben Abagyan, Ph.D.
Professor

Carlos F. Barbas III, Ph.D.*
Professor
Janet and W. Keith Kellogg II Chair, Molecular Biology

Donald E. Bashford, Ph.D.**
Associate Professor
St. Jude’s Children’s Hospital
Memphis, Tennessee

Michael N. Boddy, Ph.D.
Assistant Professor

Charles L. Brooks III, Ph.D.
Professor

Monica J. Carson, Ph.D.
Associate Professor

David A. Case, Ph.D.
Professor

Geoffrey Chang, Ph.D.*
Assistant Professor

Jerold Chun, M.D., Ph.D.
Professor

Lisa Craig, Ph.D.
Assistant Professor

Valerie De Crécy-Lagard, Ph.D.
Assistant Professor

Luis De Lecea, Ph.D.***
Associate Professor

Lluis Ribas De Pouplana, Ph.D.
Adjunct Assistant Professor

Ashok Deniz, Ph.D.
Assistant Professor

H. Jane Dyson, Ph.D.
Professor

John H. Elder, Ph.D.
Professor

Martha J. Fedor, Ph.D.*
Associate Professor

James Arthur Fee, Ph.D.
Professor of Research

Elizabeth D. Getzoff, Ph.D.****
Professor

David B. Goodin, Ph.D.
Associate Professor

David S. Goodsell, Jr., Ph.D.
Associate Professor

Joel M. Gottesfeld, Ph.D.
Professor

Robert Hallewell, D.Phil.
Adjunct Associate Professor

Jennifer Harris, Ph.D.
Assistant Professor of Biochemistry

Christian A. Hassig, Ph.D.
Adjunct Assistant Professor

Mirko Hennig, Ph.D.
Assistant Professor

John E. Johnson, Ph.D.
Professor

Gerald F. Joyce, M.D., Ph.D.*****
Professor

Ehud Keinan, Ph.D.*
Adjunct Professor

Richard A. Lerner, M.D., Ph.D.*****
President, The Scripps Research Institute
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Scott Lesley, Ph.D.
Assistant Professor of Biochemistry

Tianwei Lin, Ph.D.
Assistant Professor

Clare McGowan, Ph.D.
Associate Professor

Duncan E. McRee, Ph.D.
Adjunct Associate Professor

David P. Millar, Ph.D.
Associate Professor

Louis Noodleman, Ph.D.
Associate Professor

Arthur J. Olson, Ph.D.
Professor

James C. Paulson, Ph.D.††
Professor

Vijay Reddy, Ph.D.
Assistant Professor

Steven I. Reed, Ph.D.
Professor

Victoria A. Roberts, Ph.D.
Associate Professor

Paul Russell, Ph.D.
Professor

Michel Sanner, Ph.D.
Associate Professor

Harold Scheraga, Ph.D.
Adjunct Professor

Paul R. Schimmel, Ph.D.*****
Ernest and Jean Hahn Professor of Molecular Biology and Chemistry

Anette Schneemann, Ph.D.
Associate Professor

Subhash C. Sinha, Ph.D.*
Associate Professor

Gary Siuzdak, Ph.D.
Adjunct Associate Professor

Robyn L. Stanfield, Ph.D.
Assistant Professor

Raymond C. Stevens, Ph.D.†††
Professor

Charles D. Stout, Ph.D.
Associate Professor

Peiqing Sun, Ph.D.
Assistant Professor

J. Gregor Sutcliffe, Ph.D.
Professor

John A. Tainer, Ph.D.*
Professor

Fujie Tanaka, Ph.D.
Assistant Professor

Elizabeth Anne Thomas, Ph.D.
Assistant Professor

James R. Williamson, Ph.D.*****
Professor

Ian A. Wilson, D.Phil.*
Professor

Curt Wittenberg, Ph.D.
Associate Professor

Kurt Wüthrich, Ph.D.
Cecil H. and Ida M. Green Professor of Structural Biology

Todd O. Yeates, Ph.D.
Adjunct Professor

Guo-Fu Zhong, Ph.D.
Assistant Professor

Service Facilities

Ola Blixt, Ph.D.
Core Manager, Consortium for Functional Glycomics

John Chung, Ph.D.
Manager, Nuclear Magnetic Resonance Facilities

Gerard Kroon
Assistant Manager, Nuclear Magnetic Resonance Facilities

Michael E. Pique
Director, Graphics Development

Nahid Razi, Ph.D.
Assistant Core Manager, Consortium for Functional Glycomics

Peter Sobieszcsuk, Ph.D.
Core Manager, Consortium for Functional Glycomics

Staff Scientists

Aymeric Pierre De Parseval, Ph.D.

Karla Ewalt, Ph.D.

Brian M. Lee, Ph.D.

Maria Martinez-Yamout, Ph.D.

Garrett M. Morris, Ph.D.

Chiaki Nishimura, Ph.D.

Jeffrey Speir, Ph.D.

Manal Swairjo, Ph.D.

Mutsuo Yamaguchi, Ph.D.

Senior Research Associates


Sultan C. Agalarov, Ph.D.**
Institute of Protein Research
Puschino, Russia

David Barondeau, Ph.D.

Kirk Beebe, Ph.D.

Udayan Chatterji, Ph.D.**
Department of Immunology, Scripps Research

Brian Collins, Ph.D.

Peter B. Hedlund, M.D., Ph.D.

Neel Krishna, Ph.D.**
Children’s Hospital of the King’s Daughters
Norfolk, Virginia

Ying Chuan Lin, Ph.D.

Rebecca Page, Ph.D.

Mikhail Popkov, Ph.D.

Richard R. Rivera, Ph.D.

Lincoln Scott, Ph.D.

James Stevens, Ph.D.

Koji Tamura, Ph.D.

Liang Tang, Ph.D.

Xiang-Lei Yang, Ph.D.

Research Associates


Sunny Abraham, Ph.D.

Fabio Agnelli, Ph.D.

Marcius Da Silva Almeida, Ph.D.

Beatriz Gonzalelz Alonso, Ph.D.

Jianghong An, Ph.D.

Yu An, Ph.D.

Crystal Stacy Anglen, Ph.D.

Brigitte Anliker, Ph.D.

Joseph W. Arndt, Ph.D.

Mabelle Ashe, Ph.D.

Jamie Mitchell Bacher, Ph.D.Michael F. Bailey, Ph.D.

Christopher Baskerville, Ph.D.

Amy Christine Beltran, Ph.D.**
Miramar College
San Diego, California

Per Bengston, Ph.D.

Albert E. Beuscher, Ph.D.**
Stockholm University
Stockholm, Sweden

William Henry Bisson, Ph.D.

Pilar Blancafort, Ph.D.

Andrew Bordner, Ph.D.**
Molsoft, L.L.C.
La Jolla, California

Brian Bothner, Ph.D.**
Montana State University
Bozeman, Montana

Ronald M. Brudler, Ph.D.

Ryan Burnett, Ph.D.

Rosa Maria Cardoso, Ph.D.

Andrew Barry Carmel, Ph.D.

Jesus M. Castagnetto, Ph.D.**
San Diego Supercomputer Center
La Jolla, California

Qing Chai, Ph.D.

Eli Chapman, Ph.D.

Anju Chatterji, Ph.D.

Anton Vladislavovich Cheltsov, Ph.D.

I-Ju Chen, Ph.D.**
Department of Molecular and Experimental Medicine, Scripps Research

Jianhan Chen, Ph.D.

Jaeyoung Cho, Ph.D.

Jungwoo Choe, Ph.D.

Li-Chiou Chuang, Ph.D.

Jean-Pierre Clamme, Ph.D.

Linda Maria Columbus, Ph.D.

Adam Corper, Ph.D.

Stephane Coulon, Ph.D.**
Immunotech
Marseille, France

James Covalt, Ph.D.††††

Qizhi Cui, Ph.D.

Carla P. Da Costa, Ph.D.

Douglas Daniels, Ph.D.

Sanjib Das, Ph.D.

Paramita Dasgupta, Ph.D.

Robert De Bruin, Ph.D.

Roberto N. De Guzman, Ph.D.

Sohela De Rozieres, Ph.D.

Qingdong Deng, Ph.D.

Paula Desplats, Ph.D.

Buchi Ramachary Dhevalapally, Ph.D.

Zhanna Druzina, Ph.D.

Li-Lin Du, Ph.D.

Theresia Dunzendorfer-Matt, Ph.D.

Scott Eberhardy, Ph.D.

Marc-Olivier Ebert, Ph.D.

Stephen Edgcomb, Ph.D.

Susanna V. Ekholm-Reed, Ph.D.

Reza Mobini Farahani, Ph.D.

Michael Feig, Ph.D.**
Michigan State University
East Landing, Michigan

Daniel Felitsky, Ph.D.

Philippe Ferrara, Ph.D.**
Novartis International AG
Basel, Switzerland

Gerhard Fuhrmann, Ph.D.††††

Pierre Henri Gaillard, Ph.D.

Maria Alejandra Gamez-Abascal, Ph.D.

Hui Gao, Ph.D.

Elsa D. Garcin, Ph.D.

Edith Caroline Glazer, Ph.D.

Holger Gohlke, Ph.D.**
Johann Wolfgang Goethe-Universität
Frankfurt, Germany

Torbjorn Graslund, Ph.D.**
Royal Institute of Technology
Stockholm, Sweden

Björn Grünenfelder, Ph.D.

Gye Won Han, Ph.D.

Hongna Han, Ph.D.

Shoufa Han, Ph.D.

Wenge Han, Ph.D.

Jason W. Harger, Ph.D.

Anna-Maria Hays, Ph.D.**
Ambrx, Inc.
San Diego, California

Torsten Herrmann, Ph.D.**
ETH
Zürich, Switzerland

Yunfeng, Hu, Ph.D.

Joy Huffman, Ph.D.

Laura M. Hunsicker, Ph.D.

Yuzuru Ikehara, Ph.D.**
Aichi Cancer Center Research Institute
Nagoya, Japan

Wonpil Im, Ph.D.

Tasneem Islam, Ph.D.

Shuichiro Ito, Ph.D.

Nina Jendreyko, M.D.**
Humboldt-Universität-Charite
Berlin, Germany

Glenn C. Johns, Ph.D.

Eric C. Johnson, Ph.D.

Margaret Alice Johnson, Ph.D.

Hamid Reza Kalhor, Ph.D.

Christian Kannemeier, Ph.D.

Mili Kapoor, Ph.D.

Anebouselvy Kengadarane, Ph.D.††††

Arto Tapio Kesti, Ph.D.**
University of Oulu
Oulun Yliopisto, Finland

Yang Khandogin, Ph.D.

Iija V. Khavrutski, Ph.D.

Reza Khayat, Ph.D.

Min Ju Kim, Ph.D.

Marcy A. Kingsbury, Ph.D.

Elizabeth Kompfner, M.D.

Milka Kostic, Ph.D.

Julio Kovacs, Ph.D.

Iaroslav Kuzmine, Ph.D.

Hugo Alfredo Lago-Zarrilli, Ph.D.

Jason Lanman, Ph.D.

Jonathan C. Lansing, Ph.D.

June Hyung Lee, Ph.D.

Kelly Lee, Ph.D.

Katrina Lehmann, Ph.D.

Chenglong Li, Ph.D.

Lian-Sheng Li, Ph.D.**
Vicuron Pharmaceuticals, Inc.
Fremont, California

Vasco Liberal, Ph.D.

Michael Lietzow, Ph.D.**
Allergan, Inc.
Irvine, California

William M. Lindstrom, Ph.D.

Jianming Liu, Ph.D.**
AstraZeneca, Inc.
Mölndal, Sweden

Hui-Yue Christine Lo, Ph.D.

Timothy Lovell, Ph.D.**
AstraZeneca, Inc.
Mölndal, Sweden

Kunheng Luo, Ph.D.

John Gately Luz, Ph.D.

Che Ma, Ph.D.

Ann MacLaren, Ph.D.

Laurent Magnenat, Ph.D.

Angele Maki, Ph.D.**
Medarex, Inc.
Sunnyvale, California

Darly Joseph Manayani, Ph.D.

Maria Victoria Martin-Sanchez, Ph.D.

Beatriz Maroto, Ph.D.**
Department of Immunology, Scripps Research

Nobuyuki Mase, Ph.D.**
Shizuoka University
Shizuoka, Japan

Daniel McElheny, Ph.D.

Christian Corey Melander, Ph.D.**
North Carolina State University
Raleigh, North Carolina

Benoit Melchior, Ph.D.

David Metzgar, Ph.D.

Heiko Michael Moeller, Ph.D.

Seongho Moon, Ph.D.

Bettina Moser, Ph.D.

Christopher Myers, Ph.D.

Sreenivasa Chowdari Naidu, Ph.D.

Toru M. Nakamura, Ph.D.

Tadateru Nishikawa, Ph.D.

Eishi Noguchi, Ph.D.

Brian Nordin, Ph.D.

Karin E. Norgard-Sumnicht, Ph.D.

Brian V. Norledge, Ph.D.

Michael Oberhuber, Ph.D.

Wendy Fernandez Ochoa, Ph.D.

Yoshiaki Zenmei Ohkubo, Ph.D.

Brian L. Olson, Ph.D.

Alexey Onufriev, Ph.D.**
Virginia Polytechnic Institute and State University
Blacksburg, Virginia

Andrew Orry, Ph.D.**
Molsoft, L.L.C.
La Jolla, California

Brian Paegel, Ph.D.

Covadonga Paneda, Ph.D.

Sandeep Patel, Ph.D.

Natasha Paul, Ph.D.

Stephanie Pebernard, Ph.D.

Suzanne Peterson, Ph.D.

Wolfgang Stefan Peti, Ph.D.

Goran Pljevaljcic, Ph.D.

Corinne Chantal Ploix, Ph.D.

Stephanie Pond, Ph.D.

Owen Pornillos, Ph.D.

Daniel Joseph Price, Ph.D.

Plachikkat Krishnan Radha, Ph.D.

Grazia Daniela Raffa, Ph.D.

John Reader, Ph.D.Michael Recht, Ph.D.**
Palo Alto Research Center
Palo Alto, California

Stevens Kastrup Rehen, Ph.D.

Jean-Baptiste Reiser, Ph.D.

Thomas Holm Rod, Ph.D.**
Lund University
Lund, Sweden

Miguel A. Rodriguez-Gabriel, Ph.D.

Robin Rosenfeld, Ph.D.**
ActiveSight
San Diego, California

Stanislav Rudyak, Ph.D.

Sean Ryder, Ph.D.

Sanjita Sasmal, Ph.D.

Mika Aoyagi Scharber, Ph.D.

Jennifer S. Scorah, Ph.D.

Craig McLean Shepherd, Ph.D.

William Shih, Ph.D.

Hyunbo Shim, Ph.D.**
Xoma, L.L.C.
Berkeley, California

David S. Shin, Ph.D.

Adrian Smith, Ph.D.**
Mary Lyon Centre
Harwell, England

Holly Heaslet Soutter, Ph.D.

Natalie Spielewoy, Ph.D.

Greg Springsteen, Ph.D.

Deborah J. Stauber, Ph.D.

Derek Steiner, Ph.D.

Gudrun Stengel, Ph.D.

Daniel Stoffler, Ph.D.

Antitsa Stoycheva, Ph.D.**
Gilead Sciences
Foster City, California

Kenji Sugase, Ph.D.

Vidyasankar Sundaresan, Ph.D.

Jeff Suri, Ph.D.

Blair R. Szymczyna, Ph.D.

Florence Muriel Tama, Ph.D.

Guo-Qing Tang, Ph.D.**
Robert Wood Johnson Medical School
Piscataway, New Jersey

Jinghua Tang, Ph.D.

Nardos Tassew, Ph.D.

Hiroaki Tateno, Ph.D.

Michela Taufer, Ph.D.

Ewan Richardson Taylor, Ph.D.

Donato Tedesco, Ph.D.

Rhonda Torres, Ph.D.

Megan Wright Trevathan, Ph.D.

Frank Van Drogen, Ph.D.

Rani Parvathy Venkitakrishnan, Ph.D.††††

Philip Arno Venter, Ph.D.

Petra Verdino, Ph.D.

Stefan Vetter, Ph.D.

William Frederick Waas, Ph.D.

Shun-ichi Wada, Ph.D.

Ross Walker, Ph.D.

Lin Wang, Ph.D.

Raphaelle Winsky-Sommerer, Ph.D.

Eric L. Wise, Ph.D.

Jonathan Wojciak, Ph.D.

Dennis Wolan, Ph.D.Hyung Sik Won, Ph.D.

Timothy I. Wood, Ph.D.

Eugene Wu, Ph.D.

Lan Xu, Ph.D.

Ramesh Yadava, Ph.D.**
University of Virginia
Charlottesville, Virginia

Atsushi Yamagata, Ph.D.

Qi Yan, Ph.D.

Yong Yao, Ph.D.

Xiaoqin Ye, M.D., Ph.D.

Yongjun Ye, Ph.D.

Yong Yin, Ph.D.

Minmin Yu, Ph.D.
Advanced Light Source
Berkeley, California

Veronica Yu, Ph.D.

Yuan Yuan, Ph.D.

Dirk M. Zajonc, Ph.D.

Markus Zeeb, Ph.D.

Hui Zhao, Ph.D.6**
Pfizer Global Research and Development
La Jolla, California

Yong Zhao, Ph.D.

Peizhi Zhu, Ph.D.

Xueyong Zhu, Ph.D.

Scientific Associates


Andrew S. Arvai, M.S.

Eric Birgbauer, Ph.D.

Xiaoping Dai, Ph.D.

Liliane Dickinson, Ph.D.

Michael Allen Hanson, Ph.D.

Diane Marie Kubitz, B.A.Padmaja Natarajan, Ph.D.

Marianne Patch, Ph.D.

Gabriela Perez-Alvarado, Ph.D.

Nicholas Preece, Ph.D.

Visiting Investigators


Stephen J. Benkovic, Ph.D.
Pennsylvania State University
University Park, Pennsylvania

Astrid Graslund, Ph.D.
Stockholm University
Stockholm, Sweden

Arne Holmgren, M.D., Ph.D.
Karolinska Institutet
Stockholm, Sweden

Barry Honig, Ph.D.
Columbia University
New York, New York

Arthur Horwich, M.D.
Yale University
New Haven, Connecticut

Tai-huang Huang, Ph.D.
Academica Sinica
Taipei, Taiwan

Robert D. Rosenstein, Ph.D.
Lawrence Berkeley National Laboratory
Berkeley, California

* Joint appointment in The Skaggs Institute for Chemical Biology
** Appointment completed; new location shown
*** Joint appointment in the Department of Neuropharmacology
**** Joint appointments in the Department of Immunology and The Skaggs Institute for Chemical Biology
***** Joint appointments in the Department of Chemistry and the Skaggs Institute for Chemical Biology
Joint appointment in the Department of Cell Biology
†† Joint appointment in the Department of Molecular and Experimental Medicine
†††Joint appointment in the Department of Chemistry
††††Appointment completed

 

Structure of the integral membrane protein fatty acid amide hydrolase modeled into a lipid bilayer (determined by scientists in the laboratory of R.C. Stevens, Ph.D., Department of Molecular Biology). The enzyme (discovered and characterized by B.F. Cravatt, Ph.D., and colleagues, Department of Cell Biology) is a homodimer assembled from 63-kD subunits. This view of the enzyme highlights the central twisted β-sheet that forms the core of the structure. The inhibitor adduct methoxy arachidonyl fluorophosphonate (MAP; designed and synthesized by researchers in the laboratory of D.L. Boger, Department of Chemistry) is depicted in the active site with van der Waals surfaces.