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Scientific Report 2004


Immunology




Chairman's Overview


Staff


Richard J. Ulevitch, Ph.D.
Professor and Chairman

Bruce A. Beutler, M.D.
Professor

Roberto Baccala, Ph.D.
Assistant Professor

William Boisvert, Ph.D.*
Assistant Professor
Brigham and Women’s Hospital
Boston, Massachusetts

Gary M. Bokoch, Ph.D.**
Professor

Dennis R. Burton, Ph.D.***
Professor

David A. Cheresh, Ph.D.
Professor

Robert W. Chesnut, Ph.D.
Adjunct Associate Professor

Tsung-Hsien Chuang, Ph.D.
Assistant Professor

Charles G. Cochrane, M.D.
Professor

Neil R. Cooper, M.D.
Professor Emeritus

Linda K. Curtiss, Ph.D.
Professor

Edward A. Dennis, Ph.D.
Adjunct Professor

Miguel del Pozo, M.D., Ph.D.**
Assistant Professor

Henrik Ditzel, M.D., Ph.D.
Adjunct Professor

Frank J. Dixon, M.D.
Professor Emeritus
Director Emeritus, Scripps Research

Thomas S. Edgington, M.D.
Professor

Colleen Fearns, Ph.D.
Assistant Professor

Ann J. Feeney, Ph.D.
Associate Professor

Philippe Gallay, Ph.D.
Associate Professor

Nicholas R.J. Gascoigne, Ph.D.
Associate Professor

Peter Ghazal, Ph.D.
Adjunct Associate Professor

Howard Gray, Ph.D.
Adjunct Professor

Jiahuai Han, Ph.D.
Associate Professor

Wendy L. Havran, Ph.D.
Associate Professor

Shuang Huang, Ph.D.
Assistant Professor

Jonathan G. Kaye, Ph.D.
Associate Professor

Hidehiro Kishimoto, M.D., Ph.D.
Assistant Professor

Richard Klemke, Ph.D.
Associate Professor

Norman R. Klinman, M.D., Ph.D.
Professor

Ulla Gissi Knaus, Ph.D.
Associate Professor

Dwight H. Kono, M.D.
Associate Professor

Vladimir V. Kravchenko, Ph.D.
Assistant Professor

Jiing-Dwan Lee, Ph.D.
Associate Professor

Erguang Li, Ph.D.
Assistant Professor

Nigel Mackman, Ph.D.
Associate Professor

Michael McHeyzer-Williams, Ph.D.
Associate Professor

Dianne McKay, M.D.
Assistant Professor

Donald E. Mosier, M.D., Ph.D.
Professor

David Nemazee, Ph.D.
Professor

Glen R. Nemerow, Ph.D.
Associate Professor

Per A. Peterson, M.D., Ph.D.
Adjunct Professor

Mary Laurie Phillips, Ph.D.
Adjunct Assistant Professor

Pascal Poignard, M.D., Ph.D.
Assistant Professor

Alexander Poltorak, Ph.D.*
Assistant Professor
Tufts University
Boston, Massachusetts

Ralph A. Reisfeld, Ph.D.
Professor

Matthias Riewald, M.D.
Assistant Professor

Hugh Rosen, M.D., Ph.D.
Professor

Wolfram Ruf, M.D.
Associate Professor

Daniel R. Salomon, M.D.
Adjunct Associate Professor

Erica Ollmann Saphire, Ph.D.
Assistant Professor

Nora Sarvetnick, Ph.D.
Professor

David D. Schlaepfer, Ph.D.
Associate Professor

Allesandro Sette, Ph.D.
Adjunct Assistant Professor

Linda A. Sherman, Ph.D.
Professor

Jonathan Sprent, M.D., Ph.D.
Professor

Charles D. Surh, Ph.D.
Associate Professor

Luc Teyton, M.D., Ph.D.
Associate Professor

Argyrios N. Theofilopoulos, M.D.
Professor

Peter S. Tobias, Ph.D.
Associate Professor

Daniel Von Seggern, Ph.D.
Assistant Professor

Susan R. Webb, Ph.D.
Associate Professor

R. Anthony Williamson, Ph.D.
Assistant Professor

Curtis B. Wilson, M.D.
Professor Emeritus

Rong Xiang, M.D., Ph.D.
Assistant Professor

Staff Scientists


James Binley, Ph.D.*
La Jolla Institute for Allergy and Immunology
San Diego, California

Xin Du, Ph.D.

Cheng Liu, M.D., Ph.D.

John Mathison, Ph.D.

M. Germana Sanna, Ph.D.

Deborah Witherden, Ph.D.

Senior Research Associates


Jasimuddin Ahamed, Ph.D.

Joao da Silva Correia, Ph.D.

Amanda Gavin, Ph.D.

Peter Goebel, Ph.D.

Elisabeth Jeanclos, Ph.D.

Sung Ouk Kim, Ph.D.*
Lawson Health Research Institute
London, Ontario

Cecile King, Ph.D.

Brian Lawson, Ph.D.*
BioLegend
San Diego, California

Liguo New, Ph.D.Qilin Pan, Ph.D.

Christine Pastore, Ph.D.

Rafal Pawlinski, Ph.D.

Ramona Petrovan, Ph.D.

Andrew Saphire, Ph.D.

Dwayne Stupack, Ph.D.

Sara Maree Weis, Ph.D.

Yan Wu, Ph.D.

Tomasz Zal, Ph.D.

Michael Zwick, Ph.D.

Research Associates


Djemel Aït-Azzouzene, Ph.D.

Seyed Alavizadeh, Ph.D.

Christopher Alfonso, Ph.D.

Sandrine Arnaud-Dabernot, Ph.D.****

Matthias Belting, Ph.D.

Gourab Bhattacharjee, Ph.D.

Dafang Bian, Ph.D.

Joerg Birkenfeld, Ph.D.

Onur Boyman, Ph.D.

Carlos Cantu, Ph.D.

Sophie Chabot, Ph.D.

Akanksha Chaturvedi, Ph.D.****

Jianming Chen, Ph.D.

Zhong Chen, Ph.D.

Jae Ho Cho, Ph.D.

David Chodniewicz, Ph.D.

Jodi Connolly, Ph.D.*
Isis Pharmaceuticals, Inc.
Carlsbad, California

Jianhua Cui, Ph.D.

Aimee de Catherlineu, Ph.D.

Eleuterio De La Camara, Ph.D.

Violane Delorme, Ph.D.

Celine Der Mardirossian, Ph.D.

Becky Diebold, Ph.D.

Helen Donners, Ph.D.

Stefan Dunzendorfer, Ph.D.

Mike Eisenbraun, Ph.D.

Amr Abdelhamid El-Sheikh, Ph.D.

Celia Espinoza, Ph.D.

Paul Fallen, Ph.D.*
Beckman Coulter, Ltd.
London, England

Wing-Tze Fan, Ph.D.****

Clemens Feistritzer, M.D.

Rolf Dario Frank, Ph.D.****

Michael Franti, Ph.D.*
Progenics Pharmaceuticals, Inc.
Tarrytown, New York

Linda Frederick, Ph.D.

Phyllis Frosst, Ph.D.*
National Institutes of Health
Bethesda, Maryland

Elisabeth Gardiner, Ph.D.*
Kalypsys, Inc.
San Diego, California

Philippe Georgel, Ph.D.

Jonathan Gitlin, Ph.D.

Antje Gohla, Ph.D.Mireille Guyader, Ph.D.****

Masaaki Hayashi, M.D., Ph.D.

Tanja Heller, Ph.D.****

Natasha Hill, Ph.D.

Neil John Hime, Ph.D.

Kasper Hoebe, Ph.D.

Hong Hua, Ph.D.

Timothy Huang, Ph.D.

Hsiu-Cheng Hung, Ph.D.****

Milena Iacobelli, Ph.D.

Naaozumi Ishimaru, Ph.D.

Zhengfan Jiang, Ph.D.

Hyun-Bae Jie, Ph.D.

Euijung Jo, Ph.D.

Valeria Judkowski, Ph.D.

Young Jun Kang, Ph.D.

Charles Kaplan, Ph.D.

Ayse Kayali, Ph.D.

Hee Ok Kim, Ph.D.

Soon Ha Kim, Ph.D.****

Sungwoo Kim, Ph.D.

Elizabeth Kompfner, Ph.D.

Veera Reddy Konda, Ph.D.

Marek Kovar, Ph.D.

Joerg Krueger, M.D.

Sabine Kurz, Ph.D.

Yong Back Kwon, Ph.D.

Gary Laevsky, Ph.D.*
University of California
San Diego, California

Estelle LeClerc, Ph.D.*
University of Zürich
Zürich, Switzerland

Hyun-Ku Lee, Ph.D.

Sang-Un Lee, Ph.D.

Sung-Hyung Lee, Ph.D.

Young Kyung Lee, Ph.D.

Dorothee Leifert, M.D.*
Department of Neuropharmacology, Scripps Research

Derek Lenz, Ph.D.****

Hongbin Li, Ph.D.

Ssang-Taek Lim, Ph.D.

Rui Lin, Ph.D.

YiHsing Lin, Ph.D.****

Jeffrey Lindquist, Ph.D.

Guoxun Liu, Ph.D.

Jeng-Fen Lo, Ph.D.

Markus Loeffler, M.D.

Patricia Lopez, Ph.D.*
Smith & Nephew
La Jolla, California

Yunping Luo, Ph.D.

Michael Lyman, Ph.D.

Julie Jameson Maderazo, Ph.D.

Chitladda Mahanivong, Ph.D.

Presanta Maiti, Ph.D.

Laurent Malherbe, Ph.D.

Valerie Mallet-Designé, Ph.D.****

Beatriz Maroto, Ph.D.

Annica Martensson, Ph.D.

Florent Martin, Ph.D.*
Department of Molecular and Experimental Medicine, Scripps Research

Javier Martinez, Ph.D.

Kendra Martyn, Ph.D.****

Satyajit Mitra, Ph.D.

Suhasini Modem, Ph.D.

Andrea Motoyama, Ph.D.*
Burnham Institute
La Jolla, California

Adam E. Mullick, Ph.D.

Anil Munshi, Ph.D.

Eric Murphy, Ph.D.

Chie Nakajima, Ph.D.****

Bishnu Nayak, Ph.D.

Ron Nepomuceno, Ph.D.

Nathalie Niederberger, Ph.D.

Frank Karl Niessen, Ph.D.

Emmett O’Flaherty, Ph.D.****

Jae-Bong Park, Ph.D.*
Hallym University
Chunchon Gangwon-do, Korea

Matthew Potter, Ph.D.

Jared Purton, Ph.D.

Fenghua Qin, M.D., Ph.D.****

Christopher Ramsey, Ph.D.

Jill Ricono, Ph.D.

Mark Rubenstein, Ph.D.

Monica Ruse, Ph.D.

Sophie Rutschmann, Ph.D.

Yuichiro Sato, M.D., Ph.D.

Gernot Schabbauer, Ph.D.

Monica Schaller, Ph.D.

Andreas Schnelzer, Ph.D.****

Nicolas Schrantz, Ph.D.

Alim Seit-Nebi, Ph.D.

Suganya Selvarajah, Ph.D.

Doinita Serban, Ph.D.

Leslie Sharp, Ph.D.

Xuefei Shen, Ph.D.

Fu Dong Shi, Ph.D.

Xiaoli Shi, Ph.D.****

David Shields, Ph.D.

Yingjie Si, Ph.D.****

Irina Smirnova, Ph.D.****

Laura Solforosi, Ph.D.

Michelle Solomon, Ph.D.

Xuehong Song, Ph.D.****

Sara Stanton, Ph.D.*
Department of Cell Biology, Scripps Research

Mary Stofega, Ph.D.*
Telik, Inc.
Palo Alto, California

Konstantin Stoletov, Ph.D.

Thomas Stratmann, Ph.D.*
University of Barcelona
Barcelona, Spain

Shibing Su, Ph.D.

Koichi Tabeta, Ph.D.

Joyce Tan, Ph.D.

Joie Trifilo, Ph.D.

David Valenta, Ph.D.

Sebastian Vallee, Ph.D.

Laurent Verkoczy, Ph.D.

Meng Wang, M.D.

Yinchun Wang, Ph.D.

Zhao Wang, Ph.D.

Chenghong Wei, Ph.D.

Christopher Wiethoff, Ph.D.

Dong Wu, Ph.D.

Wenyuan Wu, Ph.D.

Yue Xu, Ph.D.

Deepak Yadav, Ph.D.

Manisha Yadav, Ph.D.*
University of California
San Diego, California

Chun Yang, Ph.D.

Jian Ming Yang, Ph.D.

Jinseong Yi, Ph.D.

Kenji Yoshida, Ph.D.

Jiangiang Yu, Ph.D.

YouQing Zhang, Ph.D.

Tieming Zhao, Ph.D.

He Zhou, Ph.D.

Zuping Zhou, Ph.D.

Scientific Associates


Rosana Gonzales-Quintial, Ph.D.

Marcie Rose Kritzik, Ph.D.

Nora Leaf

Ralph Pantophlet, Ph.D.

Susan D. Revak

Dongyuan Xia, Ph.D.

VISITING INVESTIGATORS


Robert Hoch, M.D.
Sharp Rees-Stealy
San Diego, California
 

* Appointment completed; new location shown
** Joint appointment in the Department of Cell Biology
***Joint appointment in the Department of Molecular Biology
**** Appointment completed

Section Cover For The Department Of Immunology: Crystals of the human antibody KZ52 directed against Ebola virus. An unusual feature of the Ebola virus genome is its ability to encode multiple glycoproteins with largely identical sequence yet different structures that result in different roles in pathogenesis. Crystal structures of these proteins in complex with human antibodies from survivors of Ebola virus infection will guide the design of vaccines. Work performed in the laboratory of Erica Ollmann Saphire, Ph.D.

 

Crystals of the human antibody KZ52 directed against Ebola virus. An unusual feature of the Ebola virus genome is its ability to encode multiple glycoproteins with largely identical sequence yet different structures that result in different roles in pathogenesis. Crystal structures of these proteins in complex with human antibodies from survivors of Ebola virus infection will guide the design of vaccines. Work performed in the laboratory of Erica Ollmann Saphire, Ph.D.