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Scientific Report 2004

General Clinical Research Center

Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 30th year of continuous operation. Financed by a grant of about $2 million annually from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 80 such centers in the United States that is not affiliated with a university or a medical school. The GCRC aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, to elucidate pathogenetic mechanisms of disease, and to evaluate new modes of patient management.

The GCRC provides inpatient and outpatient environments in which investigators conduct studies in humans; the protocols are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in Scripps Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of Scripps Research; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery at Scripps Green Hospital.

In addition, the GCRC operates a computer center with a database and workstation environment for the management of clinical research data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis, a research subjects advocate, and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.

Last year, the GCRC provided these services for about 500 inpatient days and 3500 outpatient visits, processed about 7700 specimens, and supported several computer-based research protocols from Scripps Research and Scripps Clinic Medical Group. Forty patient-related research protocols were active in the GCRC; the titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. A total of 69 investigators made use of the GCRC facilities last year.
Investigator Protocol Title
Bernard Babior, M.D., Ph.D. Function of Normal and Malignant Phagocytes
Ernest Beutler, M.D. Hemochromatosis: Epidemiology and Molecular Mechanisms
Dennis R. Burton, Ph.D. Human Antibodies to Infectious Agents
Dennis R. Burton, Ph.D. Normal Blood Drawing for TSRI Labs
Francis Chisari, M.D. Immunobiology and Pathogenesis of Hepatitis
Cindy Ehlers, Ph.D. EEG Markers of Alcoholism Risk
Cindy Ehlers, Ph.D. Risk Factors for Alcoholism in Asian-, African-, and Native Americans
Ann Feeney, Ph.D. Polymorphisms in Genes of the Immune System
Brunehilde Felding-Habermann, Ph.D. Integrin Activation in Breast Cancer Metastasis
Mary Jo Heeb, Ph.D. Forms of Prostate-Specific Antigen and hK2 in Cancer
Jeffery Kelly, Ph.D. Diflunisal for Familial Amyloid Polyneuropathy
Lawrence Kline, D.O. Nasal Inflammation in Obstructive Sleep Apnea Treated With CPAP
Thomas Kunicki, Ph.D. Genetic Variation in Platelet Adhesion Receptors Genetic Variation in Platelet Adhesion Receptors
Thomas Kunicki, Ph.D. Genetic Basis of Platelet-Related Aspirin Resistance
Barbara Mason, Ph.D. Naltrexone in Nicotine and Alcohol Dependence
Donald E. Mosier, M.D., Ph.D. HIV Coreceptor Switching
Michael B.A. Oldstone, M.D. Long-term Immunity After Childhood Measles Vaccination in the Presence or Absence of Circulating Measles
Pascal Poignard, M.D. Viral Evasion and HIV Entry-Blocking Strategies
Zaverio M. Ruggeri, M.D. Mechanisms of Platelet Thrombus Formation
Sanford Shattil, M.D. Proteins That Relay a11bb3 Signals to the Cytoskeleton
Jack Sipe, M.D. Long-term Clinical Follow-up Study of Subjects With Multiple Sclerosis Treated With Cladribine
Donald Stevenson, M.D. Analgesic Desensitization in Aspirin-Sensitive Asthma
Eng Tan, M.D. Immune Reactivity to Autoantigens p62, DFS-70, and PINCH in Prostate Cancer and Role in Carcinogenesis
Bruce Zuraw, M.D. Anti-inflammatory Effects of Leukotriene Receptor Antagonists
Bruce Zuraw, M.D. Disease Variables in Hereditary Angioedema
Bruce Zuraw, M.D. Initiation and Propagation of Asthmatic Inflammation
Bruce Zuraw, M.D. Rhinovirus-Mediated Transcription in Airway Inflammation

Bruce Zuraw, M.D.

Signaling in Allergic Inflammation: Kinins, Signaling, and Asthma


Frank V. Chisari, M.D.