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Scientific Report 2004


Chemistry




Chairman's Overview

Staff


K.C. Nicolaou, Ph.D.*
Professor and Chairman
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry

Phil Baran, Ph.D.
Assistant Professor

Dale L. Boger, Ph.D.*
Professor
Richard and Alice Cramer Professor of Chemistry

Bruce Clapham, Ph.D.
Assistant Professor

Sheng Ding, Ph.D.
Assistant Professor

Albert Eschenmoser, Ph.D.*
Professor

M.G. Finn, Ph.D.*
Associate Professor

Valery Fokin, Ph.D.
Assistant Professor

M. Reza Ghadiri, Ph.D.*
Professor

Inkyu Hwang, Ph.D.
Assistant Professor

Kim D. Janda, Ph.D.*
Professor
Ely R. Callaway, Jr., Chair in Chemistry

Jeffery W. Kelly, Ph.D.*
Vice President, Academic Affairs, Scripps Research
Dean, Kellogg School of Science and Technology
Lita Annenberg Hazen Professor of Chemistry

Hartmuth Kolb, Ph.D.
Associate Professor

Ramanarayanan Krishnamurthy, Ph.D.
Assistant Professor

Richard A. Lerner, M.D.**
President, The Scripps Research Institute
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Masayuki Matsushita, Ph.D.
Assistant Professor

Evan Powers, Ph.D.
Assistant Professor

Julius Rebek, Jr., Ph.D.*
Professor
Director, The Skaggs Institute for Chemical Biology

Floyd E. Romesberg, Ph.D.
Assistant Professor

Peter G. Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
Professor
W.M. Keck Professor of Chemistry

Erik J. Sorensen, Ph.D.***
Princeton University
Princeton, New Jersey

Anita Wentworth, Ph.D.
Assistant Professor

Paul Wentworth, Jr., Ph.D.

Professor Peter Wirsching, Ph.D.
Associate Professor

Chi-Huey Wong, Ph.D.*
Professor
Ernest W. Hahn Professor and Chair in Chemistry

Staff Scientists


Arun Datta, Ph.D.

Lubica Supekova, Ph.D.

Andrew Bin Zhou, Ph.D.

Instrumentation/service facilities


Raj K. Chadha, Ph.D.
Director, X-ray Crystallography Facility

Dee H. Huang, Ph.D
Director, Nuclear Magnetic Resonance Facility

Gary E. Siuzdak, Ph.D.
Director, Mass Spectrometry Facility

Senior Research Associate


Tobin Dickerson, Ph.D.

Research Associates


Sara Adamski-Werner, Ph.D.***
Senomyx, Inc.
La Jolla, California

Fabio Agnelli, Ph.D.***
Department of Molecular Biology, Scripps Research

Jung-Mo Ahn, Ph.D.

Ebru Demet Akten, Ph.D.****

Lital Alfonta, Ph.D.

Nathan Allen, Ph.D.****

Mohammad Al-Sayah, Ph.D.***
American University of Sharjah
Sharjah, United Arab Emirates

Narendra Ambhaikar, Ph.D.

Edward Alexander Anderson, Ph.D.****

John Christopher Anderson, Ph.D.***
University of California
San Francisco, California

Gonen Ashkenasy, Ph.D.

Nurit Ashkenasy, Ph.D.

Masato Atsumi, Ph.D.

Christoph Behrens, Ph.D.

Michael Best, Ph.D.

Jan Bieschke, Ph.D.

Babu Boga, Ph.D.

Daryl Bosco, Ph.D.

Mohua Bose, Ph.D.Patrick Braun, Ph.D.

Ashraf Brik, Ph.D.

Andrij Buchnyskyy, Ph.D.***
Chemical Diversity Labs, Inc.
San Diego, California

Suzanne Buck, Ph.D.***
Molecular Probes, Inc.
Eugene, Oregon

Paul Bulger, Ph.D.

Kevin Bunker, Ph.D.

Giacomo Carenzi, Ph.D.

Aileen Chang, Ph.D.

David Yu-kai Chen, Ph.D.***
Merck & Co., Inc.
Rahway, New Jersey

Shawn Chen, Ph.D.

Yanping Chen, Ph.D.

Heng Cheng, Ph.D.

Wei-Chieh Cheng, Ph.D.***
Genomics Research Institute
Taipei, Taiwan

Jodie Chin, Ph.D.

Charles Cho, Ph.D.

Younggi Choi, Ph.D.

Youhoon Chong, Ph.D.

Benoit Colasson, Ph.D.

Antonella Converso, Ph.D.

Matthew Cremeens, Ph.D.

Ashton Cropp, Ph.D.

Francesco De Riccardis, Ph.D.

Alex Deiters, Ph.D.

Konstantinos Dellios, Ph.D.

Pankaj Desai, Ph.D.David Diaz-Diaz, Ph.D.

Yun Ding, Ph.D.****

Romyr Dominque, Ph.D.

Wu Du, Ph.D.

Richard Ducray, Ph.D.****

Sergio Duron, Ph.D.***
Kalypsys, Inc.
San Diego, California

Greg Elliott, Ph.D.

Laxman Eltepu, Ph.D.

Simon Eppacher, Ph.D.

Lisa Eubanks, Ph.D.

Ming Fa, Ph.D.***
Baylor College of Medicine
Houston, Texas

Fabio Fazio, Ph.D.***
GlaxoSmithKline
Verona, Italy

James Fletcher, Ph.D.

Dirk Franke, Ph.D.****

Rebecca Fraser, Ph.D.

Yanwen Fu, Ph.D.

Jun-Ichi Furukawa, Ph.D.****

Carmen Galan, Ph.D.

Roger Galve, Ph.D.***
Consejo Superior de Investigaciones Cientìficas
Barcelona, Spain

Tesmol G. George, Ph.D.****

Nora Green, Ph.D.***
Randolf Macon College
Ashland, Virginia

Sayam Sen Gupta, Ph.D.

Young Wan Ham, Ph.D.

Akiyuki Hamasaki, Ph.D.Wooseok Han, Ph.D.

Christophe Hardouin, Ph.D.

Rebecca Holmberg, Ph.D.

Philipp Holzer, Ph.D.***
Novartis Pharma AG
Basel, Switzerland

Jiyong Hong, Ph.D.

Sukwon Hong, Ph.D.

Zhangyong Hong, Ph.D.

Daniel Horne, Ph.D.

Che-Chang (Jeff) Hsu, Ph.D.

Zheng-Zheng Huang, Ph.D.

Mary Beth Huff, Ph.D.***
Amgen, Inc.
Thousand Oaks, California

Amy Hurshman, Ph.D.

Der-Ren Hwang, Ph.D.

Hayato Ishikawa, Ph.D.

Florian Kaiser, Ph.D.****

Akira Kawamura, Ph.D.***
Hunter College of New York
New York, New York

Michael Kelso, Ph.D.

Gyungyoun Kim, Ph.D.

Sang Jick Kim, Ph.D.

Yoonkyung Kim, Ph.D.

Haris Koftis, Ph.D.

Antoni Krasinski, Ph.D.

Andreas Krebs, Ph.D.

Jane Kuzelka, Ph.D.

Byoung Se Lee, Ph.D.

Hing-Ken Lee, Ph.D.Jinq-Chyi Lee, Ph.D.

Jongkook Lee, Ph.D.

Lac Lee, Ph.D.

Sang Hyeup Lee, Ph.D.

Sanghuyp Lee, Ph.D.

Chunmei Li, Ph.D.

Yongkai Li, Ph.D.

Jiayu Liao, Ph.D.

Hee-Jong Lim, Ph.D.***
Korea Research Institute of Chemical Technology
Taejon, Korea

Qing Lin, Ph.D.***
Amylin Pharmaceuticals, Inc.
San Diego, California

TaoTao Ling, Ph.D.

Antonietta M. Lillo, Ph.D.

Vladislav Litosh, Ph.D.****

Jun Liu, Ph.D.

Junjie Liu, Ph.D.

Deborah Longbottom, Ph.D.***
Cambridge University
Cambridge, England

Jon Loren, Ph.D.

Hendrik Luesch, Ph.D.

Sunil Mandal, Ph.D.

Roman Manetsch, Ph.D.

Felix Marr, Ph.D.

Andy Martin, Ph.D.***
Kalypsys, Inc.
San Diego, California

Shigeo Matsuda, Ph.D.

Casey McComas, Ph.D.***
Wyeth Pharmaceuticals
Collegeville, Pennsylvania

Kathleen McKenzie, Ph.D.

Andrew McPherson, Ph.D.

Michael Meijler, Ph.D.

Jun-Cai Meng, Ph.D.***
Department of Cell Biology, Scripps Research

Sergio Meth, Ph.D.

Stephane Meunier, Ph.D.***
GlaxoSmithKline
Paris, France

Koji Miki, Ph.D.***
Osaka University
Osaka, Japan

Robert Milburn, Ph.D.

Kyung Hoon Min, Ph.D.

Christos Mitsos, Ph.D.

Gopi Kumar Mittapalli, Ph.D.

Vani P. Mocharla, Ph.D.

Tamsyn Montagnon, Ph.D.***
University of Crete
Crete, Greece

Yasutaka Morita, Ph.D.

Mridul Mukherji, Ph.D.

John Muldoon, Ph.D.***
Toyota Technical Center
Ann Arbor, Michigan

Oscar Munoz, Ph.D.

Jyoti Prokash Nandy, Ph.D.****

Sridhar Narayan, Ph.D.

Yasuo Norikane, Ph.D.

Mehdi Numa, Ph.D.

Jong Il Park, Ph.D.***
Crystal Genomics, Inc.
Taejon, Korea

Jay Parrish, Ph.D.***
Gilead Pharmaceuticals
Foster City, California

Steven Pfeiffer, Ph.D.

Goran Petrovic, Ph.D.

Suresh Pitram, Ph.D.

Tülay Polat, Ph.D.

Sreenivas Punna, Ph.D.

Longwu Qi, Ph.D.

Nicole Rahe, Ph.D.

Shai Rahimipour, Ph.D.

Krishnaswami S. Raja, Ph.D.***
Dynavax Technologies
Berkeley, California

Yosup Rew, Ph.D.

Stefanie Röper, Ph.D.

Martha Abena Sarpong, Ph.D.****

Pradip Kumar Sasmal, Ph.D.

Petri Saviranta, Ph.D.

Patrick Schanen, Ph.D.

Gunther Otto Scheid, Ph.D.****

Stefan Schiller, Ph.D.

Daniel Schlawe, Ph.D.

Yoshi Sekijima, Ph.D.***
Shishu University School of Medicine
Matsumoto, Japan

Akira Shigenaga, Ph.D.

Dongwoo Shin, Ph.D.

Junhwa Shin, Ph.D.

Jenny Shipway, Ph.D.****

Mikael Sodergen, Ph.D.***
Biovitrum AB
Uppsala, Sweden

Ji Young Suk, Ph.D.

Daniel Summerer, Ph.D.

Chengzao Sun, Ph.D.***
Acidophil, L.L.C.
La Jolla, California

Xiaowen Sun, Ph.D.

Wenjun Tang, Ph.D.

Rajendra Tanpure, Ph.D.

Feng Tian, Ph.D.

Eric Tippmann, Ph.D.

Thomas Tolbert, Ph.D.***
Indiana University
Bloomington, Indiana

Kristian Tryggvason, Ph.D.

Meng-Lin Tsao, Ph.D.

James Turner, Ph.D.

Haridas Vattekkatt, Ph.D.***
Indian Institute of Technology,
Delhi, India

Juraj Velcicky, Ph.D.

David Vodak, Ph.D.

Stepan Vyskocil, Ph.D.***
Millennium Pharmaceuticals, Inc.
Cambridge, Massachusetts

Jiangyun Wang, Ph.D.

Qian Wang, Ph.D.***
University of South Carolina
Columbia, South Carolina

Masaki Warashina, Ph.D.***
University of Tsukuba
Tsukuba, Japan

Gregory Watt, Ph.D.Matthew Whiting, Ph.D.

Aaron Willingham, Ph.D.

Ning Wu, Ph.D.***
Harvard University
Cambridge, Massachusetts

Guowen Xing, Ph.D.****

Hui Xiong, Ph.D.

Ran Xu, Ph.D.****

Yoichi Yamada, Ph.D.***
Institute for Molecular Science
Okazaki, Japan

Ryu Yamasaki, Ph.D.

Jiong Yang, Ph.D.

Priscilla Yang, Ph.D.***
Harvard Medical School
Cambridge, Massachusetts

Robert M. Yeh, Ph.D.

Kazuhiro Yoshida, Ph.D.***
Chiba University
Chiba, Japan

Shu-Li You, Ph.D.***
Genomics Institute of the Novartis Research Foundation
San Diego, California

Ninghui (Henry) Yu, Ph.D.

Zhanqian Yu, Ph.D.

ZhongQing Yuan, Ph.D.***
AstraZeneca
Lund, Sweden

Huaqiang Zeng, Ph.D.

Qing-Hai Zhang, Ph.D.

Qisheng Zhang, Ph.D.

Zhiwen (Jonathan) Zhang, Ph.D.

Lian Xing Zheng, Ph.D.Joerg Zimmermann, Ph.D.

Alexandros Zografos, Ph.D.*****

Visiting Investigators


Elias Couladouros, Ph.D.***
Agricultural University of Athens
Athens, Greece

Joanna Davies, Ph.D.***
Torrey Pines Institute for Molecular Studies
San Diego, California

Trond Vidar Hansen, Ph.D.
University of Oslo
Oslo, Norway

Bumpei Hatano, Ph.D.
Yamagata University
Yonezawa, Japan

Geoffrey Howlett, Ph.D.***
University of Melbourne
Victoria, Australia

Takashi Kitayama, Ph.D.
Kinki University
Nara, Japan

Jie Li, Ph.D.
Genomics Institute of the Novartis Research Foundation
San Diego, California

Luigi Gomez Paloma, Ph.D.***
University di Salerno
Fisciano, Italy

Masaaki Sawa, Ph.D.
Dainippon Pharmaceuticals Co., Ltd.
Osaka, Japan

Futoshi Shiga, Ph.D.
Kyorin Pharmaceuticals
Tokyo, Japan

Vaugn Smider, Ph.D.***
IntegriGen
Novato, California

Erik Van der Eycken, Ph.D.
Catholic University of Leuven
Heverlee, Belgium

Jan Van Maarseveen, Ph.D.***
University of Amsterdam
Amsterdam, the Netherlands

Noboru Yamamoto, Ph.D.***
Eisai Co., Ltd.
Ibaraki, Japan

Scientific Associates


Jon Ashley

George Cain, Ph.D.****

Gina Dendle

Suresh Mahajan, Ph.D.




* Joint appointment in The Skaggs Institute for Chemical Biology
** Joint appointments in The Skaggs Institute for Chemical Biology and the Department of Molecular Biology
*** Appointment completed; new location shown
**** Appointment completed

 

Stephacidin: A new lead for treatment of prostate cancer. Isolated from the fungus Aspergillus ochraceus WC76466, stephacidin B is one of the most structurally complex naturally occurring alkaloids. It has 15 rings, 9 chiral centers, and the ubiquitous 6-oxyindole substructure. Stephacidin has potent in vitro cytotoxic activity against a variety of human tumor cell lines and a novel mode of action. Researchers in the laboratory of P. Baran, Ph.D., are creating synthetic stephacidin from simple chemicals for the purpose of advancing the science of chemistry and for biological collaborations. Work done by graduate students Carlos Guerrero and Ben Hafensteiner and research associate Narendra Ambhaikar, Ph.D. Graphics by Nika Brown.