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Scientific Report 2004


Cell Biology




Chairman's Overview

Staff

Sandra L. Schmid, Ph.D.*
Professor and Chairman

Francisco Asturias, Ph.D.**
Associate Professor

William E. Balch, Ph.D.*
Professor

David Calderwood, Ph.D.***
Yale University School of Medicine
New Haven, Connecticut

Bridget Carragher, Ph.D.**
Associate Professor

Benjamin F. Cravatt, Ph.D.****
Professor

Gaudenz Danuser, Ph.D.**
Assistant Professor

Philip E. Dawson, Ph.D.*****
Assistant Professor

Colin Fletcher, Ph.D.***
Genomics Institute of the Novartis Research Foundation
San Diego, California

Velia Fowler, Ph.D.**
Professor

Martin Friedlander, M.D., Ph.D.
Associate Professor

Larry R. Gerace, Ph.D.*
Professor

Mark Ginsberg, M.D.***
University of California
San Diego, California

Klaus Hahn, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Shelley Halpain, Ph.D.
Associate Professor

Jeffrey Harper, Ph.D.***
University of Nevada
Reno, Nevada

Steve Kay, Ph.D.
Professor

Natasha Kralli, Ph.D.
Assistant Professor

Peter Kuhn, Ph.D.**
Associate Professor

David Loskutoff, Ph.D.††
Professor

Pamela Maher, Ph.D.***
Salk Institute
La Jolla, California

Mari Manchester, Ph.D.**
Associate Professor

Stephen P. Mayfield, Ph.D.*****
Associate Professor

Mark Mayford, Ph.D.
Associate Professor

Alan McLachlan, Ph.D.
Associate Professor

Lindsey Miles, Ph.D.††
Associate Professor

Ronald A. Milligan, Ph.D.**
Professor

Ulrich Müller, Ph.D.
Associate Professor

Ardem Patapoutian, Ph.D.†††
Assistant Professor

Clinton Potter, B.S.**
Associate Professor

James Quigley, Ph.D.††
Professor

Fihumiya Samad, Ph.D.***
La Jolla Institute for Molecular Medicine
San Diego, California

Sanford Shattil, Ph.D.***
University of California
San Diego, California

Lisa Stowers, Ph.D.††††
Assistant Professor

Heidi Stuhlmann, Ph.D.††
Associate Professor

Kevin F. Sullivan, Ph.D.**
Associate Professor

Peter N.T. Unwin, Ph.D.**
Professor

Clare Waterman-Storer, Ph.D.**
Associate Professor

Elizabeth Winzeler, Ph.D.†††
Assistant Professor

John Yates III, Ph.D.
Professor

Mark J. Yeager, M.D., Ph.D.
Professor

Adjunct Appointments


Alan Bell, B.S.C.S.
Xerox Palo Alto Research Center
Palo Alto, California

Marshall Bern, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Richard Bruce, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Douglas Curry, B.S. (E.E.C.S.)
Xerox Palo Alto Research Center
Palo Alto, California

Bertil Daneholt, M.D.
Karolinska Institutet
Stockholm, Sweden

Scott Elrod, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

David Goldberg, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Xiaohua Gong, Ph.D.
University of California
Berkeley, California

Eric Peeters, Ph.D.
Xerox Palo Alto Research Center
Palo Alto, California

Martin Schwartz, Ph.D.
University of Virginia
Charlottesville, Virginia

Staff Scientists


Michael Bracey, Ph.D.

Anchi Cheng, Ph.D.

Hanna Damke, Ph.D.***
University of Nevada
Reno, Nevada

Elena Deryugina, Ph.D.

Robert Fischer, Ph.D.

Jaewon Han, Ph.D.***
University of California
San Diego, California

William Kiosses, Ph.D.***
Core Microscopy Facility, Scripps Research

Mary Morrison, Ph.D.***
Lycoming College
Williamsport, Pennsylvania

Thomas Schultz, Ph.D.

Byeong Doo Song, Ph.D.

Elizabeth Wilson

Yuanxin Zhu, Ph.D.

Senior Research Associates


Eyal Banin, M.D., Ph.D.

Luisa Campagnolo, Ph.D.

Sean Conner, Ph.D.

Ralf-Peter Czekay, Ph.D.

Mark Daniels, Ph.D.

Claire Delahunty, Ph.D.

Andrei Efimov, Ph.D.

Koji Eto, Ph.D.***
University of Tokyo
Minato-ku, Tokyo, Japan

Scott E. Franklin, Ph.D.

Yuichi Kamikubo, Ph.D.

Edward Korzus, Ph.D.

William Hayes McDonald, Ph.D.***
Oak Ridge National Laboratories
Oak Ridge, Tennessee

Atsushi Otani, Ph.D.***
Kyoto University Graduate School of Medicine
Kyoto, Japan

Maria C. Subauste, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Alexei Toutchkine, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Andries Zijlstra, Ph.D.

Research Associates


Ararat Ablooglu, Ph.D.***
University of California
San Diego, California

Brian D. Adair, Ph.D.

Nobuaki Akakura, Ph.D.***
University of California
Davis, California

Nicholas Andronicos, Ph.D.†††††

Angelique Aschrafi, Ph.D.

Claudia Barros, Ph.D.

Janna Bednenko, Ph.D.

Maria Beligni, Ph.D.

Richard Belvindrah, Ph.D.

Kari Bradtke, Ph.D.

Ghislain Breton, Ph.D.

Emma Brown, Ph.D.***
Cambridge University
Cambridge, England

Florence Brunel, Ph.D.

Anja Bubeck, Ph.D.

Charito Buensuceso, Ph.D.***
University of California
San Diego, California

Barbara Calabrese, Ph.D.

Luisa Campagnolo, Ph.D.***
Universida delgi Studi de Roma Tor Vergata
Rome, Italy

Gregory Cantin, Ph.D.

Aurelia Cassany, Ph.D.

Ihsiung Chen, Ph.D.

Yei Hua Chen, Ph.D.

Smita Chitnis, Ph.D.

Fan Li Chou, Ph.D.***
University of California
San Diego, California

Jill Chrencik, Ph.D.

Jessie Chu, Ph.D.

Michael Churchill, Ph.D.

Gino Cingolani, Ph.D.***
State University of New York Upstate Medical University
Syracuse, New York

Juliana Conkright, Ph.D.

Francesco Conti, Ph.D.

Amy Cullinan, Ph.D.

Maximiliano D’Angelo, Ph.D.***
Salk Institute
La Jolla, California

Leif Dehmelt, Ph.D.

Claudia Dellas, Ph.D.

Johannes De Rooij, Ph.D.

Maddalena DeVirgilio, Ph.D.***
Instituto di Biologia e Biotecnologia Agraria
Milan, Italy

Ajay Dhaka, Ph.D.

Meng-Qui Dong, Ph.D.

Michael Dorrell, Ph.D.

Kelly A. Dryden, Ph.D.

Andrei Efimov, Ph.D.

Samer Eid, Ph.D.

Eva Farre, Ph.D.

Thomas Fath, Ph.D.

Chloe Feral, Ph.D.***
University of California
San Diego, California

Michael Fitch, Ph.D.

Elena Garcia, Ph.D.***
University of California
San Diego, California

Giovanna Giandomenico, Ph.D.***
University of Milan
Milan, Italy

Angela Glading, Ph.D.***
University of California
San Diego, California

Lawrence Goldfinger, Ph.D.***
University of California
San Diego, California

Maria Gonzalez, Ph.D.

Goodarzi Goodarz, Ph.D.***
Sigma-Aldrich Corporation
St. Louis, Missouri

Sibylla Grahn, Ph.D.***
Boehmert & Boehmert
Munich, Germany

Michael Gregory, Ph.D.†††††

Dmitriy Gremyachinskiy, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Akash Gulyani, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Cemal Gurkan, Ph.D.

Wenge Han, Ph.D.***
Department of Molecular Biology, Scripps Research

Frank Harmon, Ph.D.

Samuel Hazen, Ph.D.

Johannes Hewel, Ph.D.

Edith Hintermann, Ph.D.

Hideo Hirakata, Ph.D.

Michael Hock, Ph.D.

Louis Hodgson, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Ke Hu, Ph.D.

Cai Huang, Ph.D.***
University of California
San Diego, California

Sun Wook Hwang, Ph.D.

Takato Imaizumi, Ph.D.

Miwako Ishido, Ph.D.

Lars Jansen, Ph.D.***
University of California
San Diego, California

Anass Jawhari, Ph.D.

Nadim Jessani, Ph.D.

Lin Ji, Ph.D.

Arul Joseph, Ph.D.†††††

Jeremiah Joseph, Ph.D.

Christelle Jost, Ph.D.***
Biosite, Inc.
San Diego, California

Kristin Kain-Kuzniewski, Ph.D.***
University of California
San Diego, California

Yu-Ichi Kamikubo, Ph.D.

Kimon Kanelakis, Ph.D.

Ana Kasirer-Friede, Ph.D.***
University of California
San Diego, California

Jaqaman Khuloud, Ph.D.

Claire Kidgell, Ph.D.

Jin-Hahn Kim, Ph.D.***
Department of Molecular and Experimental Medicine, Scripps Research

Kayoko Kimbara, Ph.D.***
University of California
San Diego, California

Katsuhiro Kita, Ph.D.
Atanas Koulov, Ph.D.

Joseph Krueger, Ph.D.***
University of California
San Diego, California

Christiane Kummer, Ph.D.***
University of California
San Diego, California

Paul LaPointe, Ph.D.

Donmienne Leung, Ph.D.

John Lewis, Ph.D.

Maria Lillo, Ph.D.

Chinten Lim, Ph.D.***
University of California
San Diego, California

Klara Limback-Stokin, Ph.D.

Jennifer Lin, Ph.D.

Kimberly Littlefield, Ph.D.***
University of Washington
Friday Harbor, Washington

Ryan Littlefield, Ph.D.

Chuan-Yin Liu, Ph.D.

Hongbin Liu, Ph.D.***
Agilent Technologies
Wilmington, Delaware

Songkai Liu, Ph.D.

Sergio Lizano-Gonzalez, Ph.D.***
New York Medical College
Valhalla, New York

Dinah Loerke, Ph.D.

Michael MacCoss, Ph.D.***
University of Washington
Seattle, Washington

Matthias Machacek, Ph.D.

Sankar Maiti, Ph.D.***
Brandeis University
Waltham, Massachusetts

Paloma Mas, Ph.D.***
Institute of Molecular Biology
Barcelona, Spain

Claudio Masuda, Ph.D.

Naoki Matsuo, Ph.D.

Juncai Meng, Ph.D.

Stephan Miller, Ph.D.

Helena Mira, Ph.D.

Jennifer Mitchell, Ph.D.

Karine Monier, Ph.D.†††††

Carolyn Moores, Ph.D.***
Birbeck College
London, England

Fabrice Mouche, Ph.D.

Ronan Murphy, Ph.D.†††††

Tetsuya Nakamoto, Ph.D.***
University Medical School
Osaka City, Japan

Hiroyuki Nakamura, Ph.D.***
University of California
Davis, California

Perihan Nalbant, Ph.D.***
Department of Immunology, Scripps Research

Jacobus Neels, Ph.D.

Claire Nguyen, Ph.D.

Sherry Niessen, Ph.D.

Naoyuki Nishiya, Ph.D.***
University of California
San Diego, California

John Offer, Ph.D.

Lesley Page, Ph.D.

Ning Pan, Ph.D.

Jessica Pankuch, Ph.D.

Zee-Yong Park, Ph.D.***
Kwangju Institute of Science and Technology
Kwangju, Korea

Anthony Partridge, Ph.D.***
University of California
San Diego, California

Oliver Pertz, Ph.D.***
Department of Immunology, Scripps Research

Brian Petrich, Ph.D.

Mathew Pletcher, Ph.D.***
Genomics Institute of the Novartis Research Foundation
San Diego, California

Aaron Ponti, Ph.D.

Barbie Pornillos, Ph.D.

Natalie Prigozhina, Ph.D.

Jose Pruneda-Paz, Ph.D.

Boris Ratnikov, Ph.D.***
University of California
San Diego, California

Leon Reijmers, Ph.D.

Gang Ren, Ph.D.

Christopher Reyes, Ph.D.

Anna Reynolds, Ph.D.

Matthew Ritter, Ph.D.

Olga Rodriguez, Ph.D.

Benoit Roger, Ph.D.

Edwin Romijn, Ph.D.

Cristian Ruse, Ph.D.

Alan Saghatelian, Ph.D.

Trey Sato, Ph.D.

Mika Scharber, Ph.D.***
University of California
San Diego, California

Susann Schenk, Ph.D.***
University of Southern Denmark
Odense, Denmark

Eric C. Schirmer, Ph.D.

Dirk Schmidt, Ph.D.***
Aventis Pharma Germany
Frankfurt, Germany

Thomas Schroeter, Ph.D.

Martin Schwander, Ph.D.

Feimo Shen, Ph.D.***
University of North Carolina
Chapel Hill, North Carolina

Yoko Shiraishi, Ph.D.

Stephan Sieber, Ph.D.

Pratik Singh, Ph.D.

Alessandra Soriani, Ph.D.***
University of California
San Diego, California

Fabienne Soulet, Ph.D.

Scott Stagg, Ph.D.

Sarah Stanton, Ph.D.

Gina Story, Ph.D.

Seiji Tadokoro, Ph.D.†††††

Florian Topert, Ph.D.

Hien Tran, Ph.D.

Eleni Tzima, Ph.D.†††††

Tuija Uusitalo, Ph.D.

Agatha Van Wees, Ph.D.***
University of Amsterdam
Amsterdam, the Netherlands

John Venable, Ph.D.

Josep Villena, Ph.D.

Astrid Visser, Ph.D.***
University of Amsterdam
Amsterdam, the Netherlands

Xiaodong Wang, Ph.D.

Yan Wang, Ph.D.***
Peptimmune, Inc.
Cambridge, Massachusetts

Robert Watson, Ph.D.***
State University of New York
Stony Brook, New York

BinQing Wei, Ph.D.

Robert Williams, Ph.D.

Torsten Wittmann, Ph.D.

Harald Wodrich, Ph.D.***
Institut de Genetique Moleculaire de Montpellier
Montpellier, France

Lily Wong, Ph.D.***
University of Oklahoma College of Medicine
Oklahoma City, Oklahoma

James Wohlschlegel, Ph.D.

Christine Wu, Ph.D.

Chen Xu, Ph.D.†††††

Yun Yamanouchi, Ph.D.***
University of California
San Diego, California

Ge Yang, Ph.D.

Defne Yarar, Ph.D.

Masahiro Yasuda, Ph.D.

Rie Yasuda, Ph.D.

Quansheng Zhu, Ph.D.***
University of California
San Diego, California

Wenhong Zhu, Ph.D.

Zhongmin Zou, Ph.D.

Scientific Associates


Hilda Edith Aguilar de Diaz, M.D.

Galina Eroshkina, Ph.D.

Tinglu Guan, Ph.D.

Michael Hanson, Ph.D.

Anand Kolatkar, Ph.D.

Fakhruddin Palida, Ph.D.

Kathryn Spencer, Ph.D.

Marlon Watson, Ph.D.




* Joint appointment in the Department of Molecular Biology
** Joint appointment in the Center for Integrative Molecular Biosciences
*** Appointment completed; new location shown
**** Joint appointments in the Department of Chemistry, The Skaggs Institute for Chemical Biology, and the Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute
***** Joint appointment in The Skaggs Institute for Chemical Biology
Joint appointment in the Institute for Childhood and Neglected Diseases
††Division of Vascular Biology
†††Joint appointments in the Institute for Childhood and Neglected Diseases and the Genomics Institute of the Novartis Research Foundation
††††Joint appointment in the Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute
†††††Appointment completed


 

Stephacidin: A new lead for treatment of prostate cancer. Isolated from the fungus Aspergillus ochraceus WC76466, stephacidin B is one of the most structurally complex naturally occurring alkaloids. It has 15 rings, 9 chiral centers, and the ubiquitous 6-oxyindole substructure. Stephacidin has potent in vitro cytotoxic activity against a variety of human tumor cell lines and a novel mode of action. Researchers in the laboratory of P. Baran, Ph.D., are creating synthetic stephacidin from simple chemicals for the purpose of advancing the science of chemistry and for biological collaborations. Work done by graduate students Carlos Guerrero and Ben Hafensteiner and research associate Narendra Ambhaikar, Ph.D. Graphics by Nika Brown.