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Chisari/Last Section General Clinical Research Center

Francis V. Chisari, M.D.

E. Beutler, F.V. Chisari, B.L. Zuraw, D.R. Salomon, J.A. Koziol, S.L. Mirkis, V.B. Bagwell, E.A. Bieger, K.H. Cox

Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 26th year of continuous operation. Financed by an annual grant of about $2 million from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 75 such centers in the United States that is not affiliated with a university or medical school. The GCRC aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, elucidate pathogenetic mechanisms of disease, and evaluate new modes of patient management.

The GCRC provides inpatient and outpatient environments in which investigators conduct studies in humans; the protocols followed are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in the Scripps Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of TSRI; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery.

In addition, the GCRC operates a computer center with a Unix workstation environment for the management of clinical data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.

Last year, the GCRC provided these services for about 5800 outpatient visits, processed about 15,200 specimens, and supported 57 computer-based research protocols from TSRI and the Scripps Clinic Medical Group. Seventy-one patient-related research protocols were carried out in the GCRC; the titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. A total of 115 investigators made use of the GCRC's facilities, and 110 peer-reviewed papers and abstracts resulting from GCRC-assisted research were published last year.

Ernest Beutler, MDStudies and Enzyme Replacement Therapy in Gaucher Disease
Dennis R. Burton, PhDHuman Antibodies to Infectious Agents
Francis Chisari, MDImmunobiology and Pathogenesis of Hepatitis
Sandra C. Christiansen, MDAsthma Counseling Outcomes in School-Associated Clinics
Sandra C. Christiansen, MDFunctional Consequences of B1 BK Receptor Expression During Allergic Airway Inflammation
Denis Darko, MDFatigue and Sleep Abnormalities in HIV Infection: Identification of Therapies
Arthur Dawson, MDHypoxemia and Pulmonary Hypertension in Gaucher Disease
Cindy Ehlers, PhDEEG Markers of Alcoholism Risk
Cindy Ehlers, PhDFetal Alcohol Syndrome Studies
Cindy Ehlers, PhDResponse to Ethanol in Asian-, African-, and Native Americans
Ann Feeney, PhDMolecular Analysis of H influenzae Response
Mary Jo Heeb, PhDForms of Prostate-Specific Antigen and hK2 in Cancer
Steve Kay, PhDThe Etiology of Circadian Rhythm Sleep Disorders
Lawrence Kline, DODPAP for Obstructive Sleep Apnea
Thomas Kunicki, PhDRelationship Between Membrane Density of a2ß1 Integrin and CAD
Martin Lotz, MDPathogenetic Mediators in Arthritis
Nigel Mackman, PhDEstablishment of a New Assay to Measure Tissue Factor Activity in Whole Blood
James R. Mason, MDDICEP and Amifostine in Cancers
David A. Mathison, MDGenomic and Molecular Determinants of Airway Hyperreactivity in Human Asthma
John McHutchison, MDIntron A and Alferon-N for Hepatitis C
Lindsey Miles, PhDProthrombotic Effects in Lipoprotein(a)
Donald E. Mosier, MD, PhDAdoptive Immune Therapy in the hu-PBL-SCID Model
Donald E. Mosier, MD, PhDCoreceptor Usage and HIV Disease Kinetics
Donald E. Mosier, MD, PhDT-Cell Changes in HIV-1 Infection
Steven J. Poceta, MDEffect of Nicotine and Cigarette Smoke on Respiration
Paul Pockros, MDStudies of Interferon in Hepatitis B and Hepatitis C
Vance Rodgers, MD2-CdA for Crohn's Disease and Ulcerative Colitis
Daniel R. Salomon, MDNormal Blood-Drawing for TSRI Labs
Jack Sipe, MDCladribine (2-CdA) Treatment of Multiple Sclerosis
Donald Stevenson, MDAnalgesic Desensitization in Aspirin-Sensitive Asthma
Bruce Torbett, PhDDisruption of Human Hematopoiesis by HIV-1
Katharine Woessner, MDGene Expression of Airway Epithelial Cells in Allergic Rhinitis
Bruce Zuraw, MDAngioedema and Hageman Factor



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