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News and Publications
The Skaggs Institute For Chemical Biology
Scientific Report 1997-1998
On the front cover: The structure of the complex formed between the yeast ribosomal protein L30 (white, center) and the 5´ end of the L30 mRNA (red, foreground). One function of this protein is to autoregulate translation of its own mRNA by blocking access of the ribosome to the translational initiation codon. The ribosome (green, background), which is responsible for synthesis of proteins, is schematically shown in the distance as it scans along the mRNA (red ribbon) toward the inhibitory L30-mRNA complex, which functions as a doorstop. The L30-mRNA structure was determined by Hongyuan Mao in the laboratory of James R. Williamson by using NMR spectroscopy. Image produced by Mike Pique and James R. Williamson, Ph.D., with AVS software and Adobe Photoshop.
Investigators' Reports
Molecular Recognition and Assembly
From Catalytic Asymmetric Synthesis to the Regulation of Genes: In Vivo and In Vitro Evolution of Proteins
Studies in Molecular and Experimental Medicine
Synthetic and Bioorganic Chemistry
Chemical Physiology
Bioorganic Chemistry of Proteins
Regulation, Function, and Signaling Mechanisms of Cell Adhesion Molecules
Chemical Etiology of the Structure of Nucleic Acids
Intracellular RNA Assembly and Catalysis
Principles of Protein Structure for Chemical Recognition, Complementarity, and Catalysis
Self-Organized Autocatalytic Networks
Catalytic Antibodies and the Application of Soluble Polymers in Organic Synthesis
Catalytic Nucleic Acids for Treating the Molecular Basis of Disease
Antibody-Catalyzed Organic and Organometallic Transformations and Chemical Libraries of Annonaceous Acetogenins
Bioorganic Chemistry and Neurochemistry
Expression of Antibodies and Novel Enzymatic Functions in Algae
Chemical Synthesis and Chemical Biology
Decoding Genetic Information in Translation
Catalysis Discovery
Studies in Organic Synthesis and Bioorganic Chemistry
Master Keys for Chemical Molecular Biology From Macromolecular Structures
RNA Folding
X-ray Crystallography of Therapeutically Important Macromolecules
Bioorganic Chemistry and Biocatalysis
Studies of Macromolecular Recognition by Multidimensional Nuclear Magnetic Resonance
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