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The Skaggs Institute For Chemical Biology
Scientific Report 1997-1998


On the front cover: The structure of the complex formed between the yeast ribosomal protein L30 (white, center) and the 5´ end of the L30 mRNA (red, foreground). One function of this protein is to autoregulate translation of its own mRNA by blocking access of the ribosome to the translational initiation codon. The ribosome (green, background), which is responsible for synthesis of proteins, is schematically shown in the distance as it scans along the mRNA (red ribbon) toward the inhibitory L30-mRNA complex, which functions as a doorstop. The L30-mRNA structure was determined by Hongyuan Mao in the laboratory of James R. Williamson by using NMR spectroscopy. Image produced by Mike Pique and James R. Williamson, Ph.D., with AVS software and Adobe Photoshop.

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Molecular Recognition and Assembly 
From Catalytic Asymmetric Synthesis to the Regulation of Genes: In Vivo and In Vitro Evolution of Proteins 
Studies in Molecular and Experimental Medicine 
Synthetic and Bioorganic Chemistry 
Chemical Physiology 
Bioorganic Chemistry of Proteins 
Regulation, Function, and Signaling Mechanisms of Cell Adhesion Molecules 
Chemical Etiology of the Structure of Nucleic Acids 
Intracellular RNA Assembly and Catalysis 
Principles of Protein Structure for Chemical Recognition, Complementarity, and Catalysis 
Self-Organized Autocatalytic Networks 
Catalytic Antibodies and the Application of Soluble Polymers in Organic Synthesis 
Catalytic Nucleic Acids for Treating the Molecular Basis of Disease 
Antibody-Catalyzed Organic and Organometallic Transformations and Chemical Libraries of Annonaceous Acetogenins 
Bioorganic Chemistry and Neurochemistry 
Expression of Antibodies and Novel Enzymatic Functions in Algae 
Chemical Synthesis and Chemical Biology 
Decoding Genetic Information in Translation 
Catalysis Discovery 
Studies in Organic Synthesis and Bioorganic Chemistry 
Master Keys for Chemical Molecular Biology From Macromolecular Structures 
RNA Folding 
X-ray Crystallography of Therapeutically Important Macromolecules 
Bioorganic Chemistry and Biocatalysis 
Studies of Macromolecular Recognition by Multidimensional Nuclear Magnetic Resonance 

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