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The Skaggs Institute For Chemical Biology
Scientific Report 1999-2000

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On the front cover: Vancomycin is a clinically indispensable antibiotic and is the drug of last resort for treatment of multidrug-resistant infections. Bacterial resistance to vancomycin is now emerging. The chemical structure depicted here is a vancomycin dimer that is potent against vancomycin-resistant bacteria. The molecule was designed and synthesized in the laboratories of K.C. Nicolaou and Dale Boger, members of the Skaggs Institute. Work continues on vanomycin in these 2 laboratories and in other laboratories at TSRI (see Nicolaou et al., Angew. Chem. Int. Ed. 39:3823, 2000).


THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY

President's Introduction
Director's Overview
Staff Awards and Activities


STAFF

Julius Rebek, Jr., Ph.D.*Director and Professor
Carlos F. Barbas III, Ph.D.**Professor, Janet and W. Keith Kellogg II Chair in Molecular Biology
Ernest Beutler, M.D.***Professor, Chairman, Department of Molecular and Experimental Medicine, TSRI
Dale L. Boger, Ph.D.*Richard and Alice Cramer Professor of Chemistry
Benjamin F. Cravatt, Ph.D.****Assistant Professor
Philip Dawson, Ph.D.****Assistant Professor
Gerald M. Edelman, M.D., Ph.D.*****Professor, Chairman, Department of Neurobiology, TSRI
Albert Eschenmoser, Ph.D.*Professor
Martha J. Fedor, Ph.D.**Associate Professor
M.G. Finn, Ph.D.*Associate Professor
Elizabeth D. Getzoff, Ph.D.+Professor
M. Reza Ghadiri, Ph.D.*Professor
Kim D. Janda, Ph.D.++Professor, Ely R. Callaway, Jr., Chair in Chemistry
Gerald F. Joyce, M.D., Ph.D.++Professor
Ehud Keinan, Ph.D.**Adjunct Professor
Jeffery W. Kelly, Ph.D.*Lita Annenberg Hazen Professor of Chemistry
Richard A. Lerner, M.D.++President, TSRI, Lita Annenberg Hazen Professor of Immunochemistry, Cecil H. and Ida M. Green Chair in Chemistry
Stephen P. Mayfield, Ph.D.****Associate Professor
K.C. Nicolaou, Ph.D.*Aline W. and L.S. Skaggs Professor of Chemical Biology, Darlene Shiley Chair in Chemistry, Chairman, Department of Chemistry, TSRI
Dmitry Rudkevich, Ph.D.Assistant Professor
Paul R. Schimmel, Ph.D.++Ernest and Jean Hahn Professor and Chair of Molecular Biology and Chemistry
Peter Schultz, Ph.D.*Professor, Scripps Family Chair
K. Barry Sharpless, Ph.D.*W.M. Keck Professor
Subhash C. Sinha, Ph.D.**Associate Professor
Erik J. Sorensen, Ph.D.*Assistant Professor
John A. Tainer, Ph.D.**Professor
James R. Williamson, Ph.D.**Professor
Ian A. Wilson, D.Phil.**Professor
Chi-Huey Wong, Ph.D.*Ernest W. Hahn Professor and Chair in Chemistry
Peter E. Wright, Ph.D.**Professor, Cecil H. and Ida M. Green Investigator in Medical Research, Chairman, Department of Molecular Biology, TSRI


RESEARCH ASSOCIATES+++

Ulf Bremberg, Ph.D.
Marcus Brody, Ph.D.
Young Lag Cho, Ph.D.
Stephen L. Craig, Ph.D.
Adel Rafai Far, Ph.D.
Gebhard Haberhauer, Ph.D.
Takeharu Haino, Ph.D.
Peter Iovine, Ph.D.
Steffi Körner, Ph.D.
Ulrich Lücking, Ph.D.
Csaba Nemes, Ph.D.
Colin P. Nuckolls, Ph.D.
Adam R. Renslo, Ph.D.
Shoichi Saito, Ph.D.
Lubomir Sebo, Ph.D.
Laszlo Somogyi, Ph.D.
Stephen Starnes, Ph.D.
Niels Svenstrup, Ph.D.
Paul Wash, Ph.D.


* Joint appointment in Department of Chemistry

** Joint appointment in Department of Molecular Biology
*** Joint appointment in Department of Molecular and Experimental Medicine
**** Joint appointment in Department of Cell Biology
***** Joint appointment in Department of Neurobiology
+ Joint appointments in Departments of Molecular Biology and Immunology
++ Joint appointments in Departments of Chemistry and Molecular Biology
+++ Research associates in the laboratories of staff other than Dr. Rebek are included in the lists of authors in the individual reports.

Investigators' Reports

Cancer, AIDS, Catalysis, and the Regulation of Genes: Building Molecules With Defined Functions

Studies in Molecular and Experimental Medicine

Synthetic, Medicinal, and Bioorganic Chemistry

Chemical Physiology

Bioorganic Chemistry of Proteins

Regulation, Function, and Signaling Mechanisms of Cell Adhesion Molecules

Chemical Etiology of the Structure of Nucleic Acids

Intracellular RNA Assembly and Catalysis

Organic Chemistry With Biological Molecules

Principles of Protein Structure for Chemical Recognition, Complementarity, and Catalysis

Understanding the Complexity of Living Chemical Networks

Catalytic Antibodies: Organic Synthesis, Catalysis, and New Hapten Strategies

Catalytic Nucleic Acids for Treating the Molecular Basis of Disease

Catalytic Antibodies, Synthetic Proteins, and Annonaceous Acetogenins

Bioorganic Chemistry

Expression of Antibodies in Microalgae

Chemical Synthesis and Chemical Biology

Molecules Inside Molecules

Decoding Genetic Information in Translation

Biological Chemistry

Click Chemistry

Synthesis and Activation of Prodrugs by Antibody Catalysis

Studies in Organic Synthesis and Chemical Biology

Master Keys for Chemical Molecular Biology From Macromolecular Structures

RNA Folding

The Immune Response and the Purine Biosynthesis Pathway as Targets for Therapeutic Intervention

Bioorganic Chemistry

Studies of Macromolecular Recognition by Multidimensional Nuclear Magnetic Resonance


The Skaggs Institute For Chemical Biology Website


 

 







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