News and Publications

The Skaggs Institute For Chemical Biology
Scientific Report 1999-2000

On the front cover: Vancomycin is a clinically indispensable antibiotic and is the drug of last resort for treatment of multidrug-resistant infections. Bacterial resistance to vancomycin is now emerging. The chemical structure depicted here is a vancomycin dimer that is potent against vancomycin-resistant bacteria. The molecule was designed and synthesized in the laboratories of K.C. Nicolaou and Dale Boger, members of the Skaggs Institute. Work continues on vanomycin in these 2 laboratories and in other laboratories at TSRI (see Nicolaou et al., Angew. Chem. Int. Ed. 39:3823, 2000).

THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY

President's Introduction

Director's Overview

Staff Awards and Activities

STAFF

Julius Rebek, Jr., Ph.D.* Director and Professor

Carlos F. Barbas III, Ph.D.** Professor, Janet and W. Keith Kellogg II Chair in Molecular Biology

Ernest Beutler, M.D.*** Professor, Chairman, Department of Molecular and Experimental Medicine, TSRI

Dale L. Boger, Ph.D.* Richard and Alice Cramer Professor of Chemistry

Benjamin F. Cravatt, Ph.D.**** Assistant Professor

Philip Dawson, Ph.D.**** Assistant Professor

Gerald M. Edelman, M.D., Ph.D.***** Professor, Chairman, Department of Neurobiology, TSRI

Albert Eschenmoser, Ph.D.* Professor

Martha J. Fedor, Ph.D.** Associate Professor

M.G. Finn, Ph.D.* Associate Professor

Elizabeth D. Getzoff, Ph.D.⁺ Professor

M. Reza Ghadiri, Ph.D.* Professor

Kim D. Janda, Ph.D.⁺⁺ Professor, Ely R. Callaway, Jr., Chair in Chemistry

Gerald F. Joyce, M.D., Ph.D.⁺⁺ Professor

Ehud Keinan, Ph.D.** Adjunct Professor

Jeffery W. Kelly, Ph.D.* Lita Annenberg Hazen Professor of Chemistry

Richard A. Lerner, M.D.⁺⁺ President, TSRI, Lita Annenberg Hazen Professor of Immunochemistry, Cecil H. and Ida M. Green Chair in Chemistry

Stephen P. Mayfield, Ph.D.**** Associate Professor

K.C. Nicolaou, Ph.D.* Aline W. and L.S. Skaggs Professor of Chemical Biology, Darlene Shiley Chair in Chemistry, Chairman, Department of Chemistry, TSRI

Dmitry Rudkevich, Ph.D. Assistant Professor

Paul R. Schimmel, Ph.D.⁺⁺ Ernest and Jean Hahn Professor and Chair of Molecular Biology and Chemistry

Peter Schultz, Ph.D.* Professor, Scripps Family Chair

K. Barry Sharpless, Ph.D.* W.M. Keck Professor

Subhash C. Sinha, Ph.D.** Associate Professor

Erik J. Sorensen, Ph.D.* Assistant Professor

John A. Tainer, Ph.D.** Professor

James R. Williamson, Ph.D.** Professor

Ian A. Wilson, D.Phil.** Professor

Chi-Huey Wong, Ph.D.* Ernest W. Hahn Professor and Chair in Chemistry

Peter E. Wright, Ph.D.** Professor, Cecil H. and Ida M. Green Investigator in Medical Research, Chairman, Department of Molecular Biology, TSRI

RESEARCH ASSOCIATES⁺⁺⁺

Ulf Bremberg, Ph.D.

Marcus Brody, Ph.D.

Young Lag Cho, Ph.D.

Stephen L. Craig, Ph.D.

Adel Rafai Far, Ph.D.

Gebhard Haberhauer, Ph.D.

Takeharu Haino, Ph.D.

Peter Iovine, Ph.D.

Steffi Körner, Ph.D.

Ulrich Lücking, Ph.D.

Csaba Nemes, Ph.D.

Colin P. Nuckolls, Ph.D.

Adam R. Renslo, Ph.D.

Shoichi Saito, Ph.D.

Lubomir Sebo, Ph.D.

Laszlo Somogyi, Ph.D.

Stephen Starnes, Ph.D.

Niels Svenstrup, Ph.D.

Paul Wash, Ph.D.

* Joint appointment in Department of Chemistry

** Joint appointment in Department of Molecular Biology

*** Joint appointment in Department of Molecular and Experimental Medicine

**** Joint appointment in Department of Cell Biology

***** Joint appointment in Department of Neurobiology

⁺ Joint appointments in Departments of Molecular Biology and Immunology

⁺⁺ Joint appointments in Departments of Chemistry and Molecular Biology

⁺⁺⁺ Research associates in the laboratories of staff other than Dr. Rebek are included in the lists of authors in the individual reports.