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The Skaggs Institute
for Chemical Biology


Scientific Report 2006




President's Introduction

Director's Overview

Staff Awards and Activities

Staff



Julius Rebek, Jr., Ph.D.*
Professor and Director

Carlos F. Barbas III, Ph.D.**
Professor
Janet and W. Keith Kellogg II Chair in Molecular Biology

Tamas Bartfai, Ph.D.
Professor
Chairman, Molecular and Integrative Neurosciences Department, Scripps Research
Director, Harold L. Dorris Neurological Research Institute

Ernest Beutler, M.D.***
Professor
Chairman, Department of Molecular and Experimental Medicine, Scripps Research

Dale L. Boger, Ph.D.*
Richard and Alice Cramer Professor of Chemistry

Geoffrey Chang, Ph.D.**
Associate Professor

Benjamin F. Cravatt, Ph.D.****
Professor
Director, Helen L. Dorris Child and Adolescent Neuro-Psychiatric Disorder Institute

Philip Dawson, Ph.D.*****
Associate Professor

Gerald M. Edelman, M.D., Ph.D.
Professor
Chairman, Department of Neurobiology, Scripps Research

Albert Eschenmoser, Ph.D.*
Professor

Martha J. Fedor, Ph.D.**
Associate Professor

M.G. Finn, Ph.D.*
Associate Professor

Elizabeth D. Getzoff, Ph.D.††
Professor

M. Reza Ghadiri, Ph.D.*
Professor

Kim D. Janda, Ph.D.*
Professor
Ely R. Callaway, Jr., Chair in Chemistry
Director, The Worm Institute for Research and Medicine

Gerald F. Joyce, M.D., Ph.D.†††
Professor
Dean, Faculty

Ehud Keinan, Ph.D.**
Adjunct Professor

Jeffery W. Kelly, Ph.D.*
Lita Annenberg Hazen Professor of Chemistry
Dean, Graduate and Postgraduate Studies

Richard A. Lerner, M.D.†††
President, Scripps Research
Lita Annenberg Hazen Professor of Immunochemistry
Cecil H. and Ida M. Green Chair in Chemistry

Stephen P. Mayfield, Ph.D.*****
Professor
Associate Dean, Kellogg School of Science and Technology

K.C. Nicolaou, Ph.D.*
Aline W. and L.S. Skaggs Professor of Chemical Biology
Darlene Shiley Chair in Chemistry
Chairman, Department of Chemistry, Scripps Research

Paul R. Schimmel, Ph.D.†††
Ernest and Jean Hahn Professor and Chair in Molecular Biology and Chemistry

Peter Schultz, Ph.D.*
Professor
Scripps Family Chair

K. Barry Sharpless, Ph.D.*
W.M. Keck Professor of Chemistry

Subhash C. Sinha, Ph.D.**
Associate Professor

John A. Tainer, Ph.D.**
Professor

James R. Williamson, Ph.D.†††
Professor
Associate Dean, Kellogg School of Science and Technology

Ian A. Wilson, D.Phil.**
Professor

Chi-Huey Wong, Ph.D.*
Ernest W. Hahn Professor and Chair in Chemistry

Peter E. Wright, Ph.D.**
Professor
Cecil H. and Ida M. Green Investigator in Biomedical Research
Chairman, Department of Molecular Biology, Scripps Research

Kurt Wüthrich, Ph.D.†††
Cecil H. and Ida M. Green Visiting Professor of Structural Biology

Research Associates


Dariush Ajami, Ph.D.

Elizabeth Barrett, Ph.D.

Sara Butterfield, Ph.D.

Alexandre Carella, Ph.D.

Naran Gombosuren, Ph.D.

Clemens Haas, Ph.D.

Richard J. Hooley, Ph.D.

Junli Hou, Ph.D.

Tetsuo Iwasawa, Ph.D.

Enrique Mann, Ph.D.

Lionel Moisan, Ph.D.

Andrew Myles, Ph.D.

Severin Odermatt, Ph.D.

Riccardo Salvio, Ph.D.

Michael Schramm, Ph.D.

Siddhartha Shenoy, Ph.D.

Alessandro Volonterio, Ph.D.

Felix Zelder, Ph.D.

* Joint appointment in the Department of Chemistry
** Joint appointment in the Department of Molecular Biology
*** Joint appointment in the Department of Molecular and Experimental Medicine
**** Joint appointments in the Departments of Cell Biology and Chemistry
***** Joint appointment in the Department of Cell Biology
Joint appointment in the Department of Neurobiology
†† Joint appointments in the Departments of Molecular Biology and Immunology
††† Joint appointments in the Departments of Chemistry and Molecular Biology

 

Front cover: Ribbon diagram of the crystal structure of an influenza hemagglutinin from a recent highly pathogenic “bird flu” virus that killed a 10-year-old Vietnamese boy in 2004. The recombinant expression system was developed by J. Stevens, Ph.D., an assistant professor in the laboratory of I.A. Wilson, D.Phil. In collaboration with O. Blixt, Ph.D., an assistant professor in the laboratory of J. Paulson, Ph.D., Scripps Research, the technology has been integrated with a recently developed glycan microarray. The microarrays are used to assess binding of these molecules to avian and human glycan receptors and, when combined with mutations, the possible routes a virus may take to adapt from birds to the human population. Future development of these glycan microarray technologies could enable rapid assessment of emerging viruses to detect receptor specificities that increase risk to the human population. Figure provided by Dr. Stevens.