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News Release Archives

1987 - 2016

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2006
  • December 26, 2006
    Study Identifies Glucose "Sensor" That Plays Dual Role in Glucose Metabolism and Fat Synthesis
    In a new study, scientists at The Scripps Research Institute have described for the first time a glucose activated sensor that acts as a switch to decrease production of endogenous glucose in the liver, and increase conversion of glucose to fat for storage in adipose tissue.

  • December 20, 2006
    Scripps Research Study Questions Need for Potential Vaccine Additive
    A team of scientists at The Scripps Research Institute has published a study that questions the need for incorporating an ingredient—TLR ligands— in vaccines to increase their effectiveness. Excluding TLR ligands would help keep down manufacturing costs and would avoid this ingredient’s potential side effects, such as inflammation and autoimmune syndromes.

  • November 30, 2006
    The Scripps Research Institute Enters Major Five-Year $100 Million Collaboration with Pfizer
    The Scripps Research Institute announced it has entered into a five year research collaboration with Pfizer Global Research and Development to advance scientific knowledge of uncured diseases and novel ways to treat them, making full use of emerging technologies and resident talent from both organizations.

  • November 17, 2006
    Scientists Identify Cells That Promote Repair of Blood Vessels in the Eye
    Scientists at The Scripps Research Institute have discovered a method of repairing and normalizing blood vessels in the eye through the use of stem cells derived from bone marrow. These findings may point to a new approach for developing treatments for a certain type of eye diseases.
  • November 16, 2006
    Protein "Chaperone" Interactions Found to Play Major Role in Cystic Fibrosis
    Scientists at The Scripps Research Institute have described for the first time key protein interactions that contribute to the development of cystic fibrosis. These findings may provide a new framework for the correction of cystic fibrosis and other protein folding diseases.

  • November 2, 2006
    Reduced Body Temperature Extends Lifespan in Study from The Scripps Research Institute
    Scientists at The Scripps Research Institute have found that reducing the core body temperature of mice extends their median lifespan by up to 20 percent. This is the first time that changes in body temperature have been shown to affect lifespan in warm-blooded animals.

  • October 31, 2006
    Scientists Identify Synthetic Compound That Keeps Stem Cells Young
    A team of scientists from The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation, and the Max Planck Institute for Molecular Biomedicine has discovered a new synthetic compound that can support growth and self-renewal of mouse embryonic stem cells, offering a simple alternative to current growth conditions that may vary batch-to-batch and confuse experimental results.

  • October 20, 2006
    Study Offers Innovative Profile of Enzyme That Aids Tumor Growth
    Using an innovative profiling strategy, scientists at The Scripps Research Institute have characterized an enzyme that is "highly elevated" in aggressive human tumor cells. When the enzyme, KIAA1363, was inactivated, it impaired tumor growth and migration in both ovarian and breast cancer cells, suggesting that inhibitors of this enzyme may prove valuable in the treatment of multiple types of cancer.

  • October 19, 2006
    New Study Shows How Genetic Repair Mechanism Helps Seal DNA Breaks
    A new study by researchers from The Scripps Research Institute, Lawrence Berkeley National Laboratory, the Washington University School of Medicine, and the University of Maryland has provided a clearer picture of the final steps of a critical DNA repair process. When these repair processes go awry, cells can malfunction, die, or become cancerous.

  • October 5, 2006
    $38 Million Grant Awarded to Alcohol Research Consortium Led by Scripps Research Institute Scientist
    The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has funded a five-year, $38 million Integrative Neuroscience Initiative on Alcoholism grant to support a consortium led by a scientist at The Scripps Research Institute. The multi-institutional group aims to identify the molecular basis of alcoholism, establishing a platform upon which future treatments can be built.

  • September 19, 2006
    Study Details Structural Changes of a Key Catalytic Enzyme
    Scientists at The Scripps Research Institute have detailed a new hypothesis of how a key catalytic enzyme, dihydrofolate reductase (DHFR)--which is the target of several anticancer and antibiotic therapies--cycles through structural changes as it plays a critical role in promoting cell growth and proliferation.

  • September 14, 2006
    New Study Pinpoints Unique Genetic Susceptibility for Viral Encephalitis
    Working in close collaboration with a group of French researchers, scientists from The Scripps Research Institute have helped uncover a unique genetic immunodeficiency that leaves patients vulnerable to herpes simplex encephalitis, a rare yet devastating infection of the brain that affects a small minority of people infected with a common virus.

  • September 13, 2006
    The Scripps Research Institute, McDonald's Align to Fight Childhood Obesity and Type 2 Diabetes
    The Scripps Research Institute and McDonald's today announced a collaboration regarding research and educational initiatives to drive progress toward a solution to childhood obesity and Type 2 diabetes. McDonald's will contribute $2 million to The Scripps Research Institute to address these critical health issues facing America's youth.

  • September 8, 2006
    Study Shows Enzyme Builds Neurotransmitters Via Newly Discovered Pathway
    Scientists at The Scripps Research Institute have uncovered a previously unknown function of an enzyme that appears to play a primary role in the biosynthesis of a large class of lipids that help modulate diverse physiological processes, including anxiety, inflammation, learning and memory, and appetite.

  • September 7, 2006
    Consortium for Functional Glycomics Awarded $40.7 Million "Glue" Grant
    The Scripps Research Institute's Consortium for Functional Glycomics has received a $40.7 million "glue" grant for the international group of some 300 participating scientists to continue collaborative study of the complex dynamics of protein-carbohydrate interactions.

  • August 31, 2006
    New Study Unveils Structure of Key Component of Antibiotic Resistant Bacteria
    Working in close collaboration with other researchers, scientists from The Scripps Research Institute have uncovered for the first time the structural chemistry behind the "astonishing multi-functionality" of the bacterial GC (for gonococcal) Type IV pilus filament, which plays an essential role in Neisseria gonorrhoeae pathogenesis.

  • August 20, 2006
    Scripps Research Team Reverses Friedreich's Ataxia Defect in Cell Culture
    A team from The Scripps Research Institute and the University of California School of Medicine has developed compounds that reactivate the gene responsible for the neurodegenerative disease Friedreich's ataxia, offering hope for an effective treatment for this devastating and often deadly condition.

  • August 18, 2006
    Media Advisory
    Local High School Students and Teachers Present Results of Summer Science Projects at The Scripps Research Institute.

  • August 10, 2006
    Scientists Discover Age-Regulated Cellular Activities That Protect Against Protein Aggregation
    By disrupting the aging process in an organism, scientists at The Scripps Research Institute and the Salk Institute for Biological Studies have discovered two mechanisms in an animal model of Alzheimer's disease that protect cells against protein aggregation that leads to damage called "proteotoxicity." .

  • August 9, 2006
    Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease
    Scientists at The Scripps Research Institute have found that the active ingredient in marijuana, tetrahydrocannabinol or THC, inhibits the formation of amyloid plaque, the primary pathological marker for Alzheimer's disease. In fact, the study said, THC is "a considerably superior inhibitor of [amyloid plaque] aggregation" to several currently approved drugs for treating the disease.

  • July 31, 2006
    Scripps Research Scientists Successfully Test New Anti-Obesity Vaccine
    In what may be the first published breakthrough of its kind in the global battle against obesity, scientists at The Scripps Research Institute have developed an anti-obesity vaccine that significantly slowed weight gain and reduced body fat in animal models.

  • July 30, 2006
    Newly Discovered Genetic Abnormality Shown to Cause Acute Myeloid Leukemia
    Working in collaboration with international researchers, scientists from The Scripps Research Institute have uncovered a new genetic abnormality that results in the rapid development of acute myeloid leukemia (AML) in animal models. These findings could lead to new ways of diagnosing and controlling development of a variety of human diseases, including leukemia and other cancers that result from certain types of genetic defects.

  • July 24, 2006
    "An Intimate Evening with Craig Chaquico"
    Craig Chaquico, the renowned lead guitarist of Jefferson Airplane/Starship and highly acclaimed contemporary instrumental artist, will perform at a dinner on August 13 to benefit the Molly Baber Research Fund at The Scripps Research Institute.

  • July 10, 2006
    Researchers Unveil Strategy for Creating Actively Programmed Anti-Cancer Molecules
    Scientists at The Scripps Research Institute and The Skaggs Institute for Chemical Biology have developed a unique assembly strategy to produce an anti-cancer targeting antibody, an approach that combines the merits of small molecule drug design with immunotherapy.

  • July 9, 2006
    Researchers Use New Chemical Probe to Manipulate Protective Inner Barriers
    Scientists at The Scripps Research Institute and the University of California, Irvine, have developed a chemical tool that allows them to manipulate control of the passage of substances through the barriers between blood and organ tissues.

  • July 6, 2006
    Prion Disease Agent Causes Heart Damage in Mouse Study
    A team of researchers at The Scripps Research Institute, the University of California, San Diego (UCSD), and Rocky Mountain Laboratories of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH), has shown for the first time that laboratory mice infected with the agent of scrapie—a brain-wasting disease of sheep—demonstrate high levels of the scrapie agent in their heart 300 days after being infected in the brain.

  • June 26, 2006
    Biogen Idec Foundation Funds Summer Teacher Internship Program At The Scripps Research Institute
    The Biogen Idec Foundation has donated $25,000 to support three teachers from San Diego public schools in The Scripps Research Institute's Summer Internship Program for Teachers.

  • June 22, 2006
    Researchers Map Infectious Hepatitis B Virus
    Scientists at The Scripps Research Institute have analyzed the structure of hepatitis B virus and found that it has unique features that distinguish it from other enveloped viruses such as influenza and herpes virus.

  • June 15, 2006
    Study Points to Genes Responsible for Malaria Parasite's Survival in Face of Attempts to Eradicate It
    A team of scientists at The Scripps Research Institute, Harvard University, the University of Chicago, the Genomics Institute of the Novartis Research Foundation, and Cheik Anta Diop University (Senegal) has discovered hundreds of novel genes that may help the malaria parasite evade destruction by the human immune system and anti-malarial drugs.

  • June 8, 2006
    Study Uncovers "Significant" Functional Differences of Novel Estrogen Receptor
    Scientists at The Scripps Research Institute, working in collaboration with researchers from Creighton University and the Medical College of Zhejiang University (P.R. China), have discovered a novel variant of a known human estrogen receptor (hER-a66).

  • May 31, 2006
    Study Links Effects of Withdrawal to Compulsive Drug Use and Craving
    A team of scientists at The Scripps Research Institute; the National Institutes of Health Animal Center; and the University of Tokushima Graduate School (Japan) has provided some of the first evidence that compulsive drug use stems not from obtaining a drug’s pleasurable effects, but from an aversion to drug withdrawal.

  • May 22, 2006
    John J. Moores Elected Chair of Scripps Research Institute Board of Trustees
    The Scripps Research Institute Board of Trustees today elected San Diego business leader and philanthropist John J. Moores as its new chair. Mr. Moores has been a Scripps Research trustee since 1997.

  • May 19, 2006
    Scripps Research Institute Honors Alice Sullivan and Alexander Dreyfoos During Commencement Ceremonies Today
    The Scripps Research Institute's Kellogg School of Science and Technology awards honorary degrees today to retired California Superior Court Judge Alice D. Sullivan, outgoing chair of the Institute's Board of Trustees, and to entrepreneur, inventor, and philanthropist Alexander W. Dreyfoos, a member of the board.

  • May 19, 2006
    Media Advisory
    The Scripps Research Institute to Award Doctoral Degrees to 31 Young Scientists; Honorary Doctorates to Go to Retiring Board Chair, Judge Alice D. Sullivan, and to Inventor, Entrepreneur, and Philanthropist Alexander W. Dreyfoos

  • May 18, 2006
    New Study Suggests Virus Uses Pressure to Sense when Full of DNA
    A team of scientists from The Scripps Research Institute, the University of Alabama, and the University of Utah have created a three-dimensional reconstruction of the complete structure of the virus P22. This structure suggests that the virus uses a pressure mechanism to stop DNA loading, a mechanism that offers a potential drug target.

  • May 17, 2006
    Study Details Hepatitis C Ability to Block Immune System Response
    A team of scientists at The Scripps Research Institute has shed light on one mechanism the hepatitis C virus uses to inhibit the immune system and promote its own survival. Results of the study may help in the development of new approaches to the treatment of hepatitis C virus.

  • May 15, 2006
    New Study Reveals Signaling Pathways Required for Expansion of Pancreas Stem Cells
    A team of scientists at The Scripps Research Institute has published a new study of important signaling pathways that are required for the expansion of pancreas stem cells, work that may lead to strategies to prevent or reverse insulin-dependent diabetes mellitus (IDDM).

  • May 4, 2006
    New Study Reveals Structure of E. Coli multidrug Transporter Protein
    Scientists at The Scripps Research Institute have determined the x-ray structure of EmrD, a multidrug transporter protein from Escherichia coli (E. coli), a common bacteria known to cause several food-borne illnesses.

  • May 2, 2006
    Study Results Offer Guidance in Treatment of Alcohol Dependence
    A large-scale study of different treatment approaches for alcohol dependence underlines that medication can play a key role in treatment.

  • April 26, 2006
    Immune Response to HIV in the Brain a "Double-Edged Sword"
    A team of researchers at The Scripps Research Institute has shed new light on the molecular basis of problems with brain function in models chronically infected with an immune deficiency virus similar to human immunodeficiency virus (HIV), the cause of acquired immune deficiency syndrome (AIDS). The findings may ultimately lead to new therapeutic interventions to prevent or reverse nervous system disorders in HIV-infected individuals.

  • April 25, 2006
    Revealing the Secrets of WRN
    A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.

  • April 20, 2006
    Lack of a Key Enzyme Dramatically Increases Resistance to Sepsis
    Scientists at The Scripps Research Institute, The La Jolla Institute of Allergy and Immunology, and Merck Research Laboratories have uncovered a "fundamentally new role" for an enzyme that when present in vivo in certain forms impedes the immune response to bacterial infection.

  • April 18, 2006
    Study Shows Gene Candidates for Predisposition to Alcohol Abuse
    A collaborative study by scientists at The Scripps Research Institute as part of the Integrative Neuroscience Initiative on Alcoholism Consortium (INIA) have identified some 3,800 "unique genes" that may determine a predisposition for a high degree of alcohol intake.

  • April 6, 2006
    Enzyme Crystal Structure Reveals "Unexpected" Genome Repair Functions
    Scientists at The Scripps Research Institute and Lawrence Berkeley National Laboratory have determined the crystal structure of an enzyme called xeroderma pigmentosum group B (XPB) helicase, identifying several unexpected functions and helping to address important questions about the enzyme's role in DNA transcription and repair.

  • March 31, 2006
    Dyadic Partners with Scripps Florida to Annotate Dyadic's Proprietary Cl Genome
    Dyadic International, Inc. (AMEX: OIL), a biotechnology company, announced today that it has engaged The Scripps Research Institute to work with Dyadic scientists to provide a complete annotation of the genome of Dyadic's proprietary fungal organism, Chrysosporium lucknowense ("Cl"), which was sequenced by another vendor last year.

  • March 24, 2006
    New Class of Enzyme Inhibitors Block Replication of SARS Virus
    Scientists at The Scripps Research Institute have discovered a class of compounds that block the SARS virus from replicating, a finding that may open the door to new drug targets against the deadly disease.

  • March 24, 2006
    "Accelerated Evolution" Converts RNA Enzyme to DNA Enzyme In Vitro
    Scientists at The Scripps Research Institute have successfully converted an RNA enzyme (ribozyme) into a DNA enzyme (deoxyribozyme) through a process of accelerated in vitro evolution.

  • March 17, 2006
    Four of the Nation's Preeminent Research Institutions Announce Stem Cell Research Alliance
    Four of the nation's preeminent research institutions, all based in San Diego, have announced their commitment to join forces in establishing an independent, non-profit consortium dedicated to stem cell research.

  • March 16, 2006
    Minor Mutations in Avian Flu Virus Increase Chances of Human Infection
    Scientists at The Scripps Research Institute, the Centers for Disease Control, and the Armed Forces Institute of Pathology have identified what the researchers described as a possible pathway for a particularly virulent strain of the avian flu virus H5N1 "to gain a foothold in the human population."

  • March 14, 2006
    Newly Discovered Small Molecules "Superactivate" Botox
    Scientists at The Scripps Research Institute have discovered several small molecules that can "superactivate" the botulinum neurotoxin (BoNT), the commonly used cosmetic treatment for wrinkles known as Botox that has a number of therapeutic uses.

  • March 9, 2006
    Novel Method Reveals How Menthol Creates Cold Sensations
    Scientists at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have developed a method that can aid in understanding how certain proteins can be activated.

  • February 27, 2006
    Scripps Research Institute's Dr. Charles G. Cochrane to Lecture on a New Therapy to Save Lives of Infants with Lung Disease
    The Scripps Research Institute will present a lecture by Charles G. Cochrane, M.D., Professor Emeritus in the Institute's Department of Immunology, this Sunday, March 5 at 2 p.m. at The Estancia La Jolla Hotel and Spa.

  • February 27, 2006
    Fluorescent Viral Nanoparticles Permit High Resolution In Vivo Vascular Imaging
    Scientists at The Scripps Research Institute have shown that cowpea mosaic virus (CPMV) can be used as an "exceptionally bright" imaging agent that permits high resolution in vivo visualization of the vascular endothelium, the cells that line the inside of blood vessels, for as long as 72 hours.

  • February 20, 2006
    New Study Shows Antibody-Interleukin Complexes Stimulate Immune Responses
    Scientists at The Scripps Research Institute have shown that injections of a certain cytokine together with the right monoclonal antibody increases white blood cells that coordinate immune responses to tumor and infected cells.

  • February 16, 2006
    IBM and Scripps Research Institute to Collaborate on Pandemic Research
    IBM and The Scripps Research Institute today announced a collaborative initiative to conduct advanced research on pandemic viruses leveraging the industry-leading talent and technology from both organizations. The objective of "Project Check-mate" is to develop means to anticipate, manage and contain infectious diseases.

  • February 15, 2006
    New Research from Magnet lab, Scripps Florida Gives Scientists Powerful Tool for Drug Discovery
    Researchers at Florida State University's National High Magnetic Field Laboratory and Scripps Florida have developed and evaluated a robust new system for analyzing how drugs bind to proteins. This groundbreaking work could speed the delivery of potential new drugs and improve existing ones.

  • February 12, 2006
    Study Reveals Mechanism for Maintaining Circadian Rhythms in Mammals
    Scientists from The Scripps Research Institute and RIKEN, a Japanese research institute, have validated a key step in the mechanism of the circadian clock in mammals. Many critical human activities including sleeping, eating, and even hormonal activity are determined by circadian rhythms, fundamental functions that adapt to the cycle of light and dark and are controlled at the genetic level.

  • February 7, 2006
    High Resolution "Snapshots" Detail Dynamics of a Cocaine Antibody
    Scientists at The Scripps Research Institute have revealed for the first time a series of molecular structures of a specific cocaine-degrading monoclonal antibody Fab' fragment during the complete catalytic process—a chain of events that breaks the drug into nontoxic pieces.

  • February 6, 2006
    Scientists Re-engineer a Well-Known Antibiotic to Counter Drug Resistance
    Scientists at The Scripps Research Institute have successfully re-engineered a well-known antibiotic to insure its effectiveness against sensitive as well as resistant enterococci, a common strain of bacteria responsible for widespread hospital infections.

  • January 31, 2006
    Protein Found to Control Tumor Growth in Certain Breast Cancers
    Scientists from The Scripps Research Institute and the Xiamen University School of Life Sciences, Fujian, People's Republic of China, have uncovered a new and potentially important function for the protein Nod1, inhibiting the growth of estrogen sensitive human breast cancer cells.

  • January 20, 2006
    Scripps Florida Opens Its Cutting-edge Screening Technology to Florida Scientists
    Officials at Scripps Florida today announced the launch of the biomedical research institute's "Access to Technologies" program, which invites scientists from Florida universities and other academic research institutions to use state-of-the-art screening technologies at Scripps Florida's facilities in Jupiter for qualifying projects.

  • January 16, 2006
    New Technology Effectively Gauges Specificity of Influenza Strains, Including 1918 Spanish Flu
    A team of researchers led by scientists from The Scripps Research Institute has used a new technology called a glycan array to survey samples of coat proteins from various strains of human and avian viruses, including from the deadly 1918 influenza outbreak know as the Spanish Flu.

  • January 13, 2006
    Study Reveals Unusual Structure of Cellular Transport Nanocage
    A new study by scientists at The Scripps Research Institute has revealed for the first time the structure of Sec13/31, a "nanocage" that transports a large body of proteins from the endoplasmic reticulum (ER), which makes up more than half the total internal cell membrane, to other regions of the cell.
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  • October 26, 2000
    TSRI Scientist Wins Presidential Early Career Award
    Geoffrey Chang, Ph.D., Assistant Professor, Department of Molecular Biology, was named by President Clinton as one of the recipients of the fifth annual Presidential Early Career Awards for Scientists and Engineers.

  • September 26, 2000
    New Genomic Center Funded To Advance HighThroughput Protein Structure Determination
    The Joint Center for Structural Genomics (JCSG), a consortium of California scientific research organizations, has received a National Institutes of Health (NIH) grant of $24 million over a five- year period to expand on the body of knowledge made av ailable by the completion of the human and other genome sequencing projects.

  • August 4, 2000
    TSRI Scientists Clone Gene that Regulates Circadian Rhythms in Plants
    Scientists at TSRI have cloned a gene that regulates circadian rhythms in plants, providing an increased understanding -- on a molecular level -- of the processes that enable organisms to anticipate and adapt to daily variations in the environment.

  • July 6, 2000
    Chi-Huey Wong, Ph.D., Receives 2000 Presidential Green Chemistry Award
    Chi-Huey Wong, Ph.D., Professor, Department of Chemistry and The Skaggs Institute at The Scripps Research Institute (TSRI), has been selected to receive a 2000 Presidential Green Chemistry Challenge Award, jointly presented by the Director of the United States Environmental Protection Agency, the Director of the White House Office of Science and Technology and President of the American Chemical Society.

  • June 1, 2000
    Sandra L. Schmid, Ph.D., Named to Head Department of Cell Biology
    Professor Sandra L. Schmid, Ph.D., The Scripps Research Institute (TSRI), has been named Chairman of the Department of Cell Biology, effective July 1, 2000, according to Richard A. Lerner, M.D., TSRI President.

  • May 25, 2000
    Ian A. Wilson, D.Phil., Elected to Royal Society
    Ian A. Wilson, D.Phil., Professor, Department of Molecular Biology and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI), has been elected to fellowship in the Royal Society, the independent scientific academy of the United Kingdom, dedicated to promoting excellence in science.

  • March 31, 2000
    The Genetics of Aging
    Gradual genetic changes may be the source of many, if not all illnesses of aging, including breast cancer, osteoporosis, Alzheimer's disease and arthritis. A new study by scientists in The Skaggs Institute for Chemical Biology at The Scripps Research Institute in La Jolla and the Genomics Institute of the Novartis Research Foundation, published in the March 31 issue of Science, concludes that human aging and its associated diseases and conditions can be traced to a gradual increase in cell division errors in tissues throughout the body.

  • January 28, 2000
    Software for the Genome Created by TSRI Scientists
    Scientists at TSRI have developed a method of producing and combining proteins as modular building blocks capable of functioning as genetic switches to turn on or off genes on demand.

  • January 26, 2000
    Scientists Discover Evolutionary Adaptation to DNA Repair in Human Cells
    Researchers studying a key human DNA repair enzyme have discovered an evolutionary adaptation that highlights a fundamental advantage in the way human cells repair damage to their DNA.

  • January 21, 2000
    K. Barry Sharpless Receives National Academy of Sciences Award in Chemical Sciences
    K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry in the Department of Chemistry and The Skaggs Institute for Chemical Biology, has been selected to receive the National Academy of Sciences Award in Chemical Sciences.

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