The Mowen Laboratory
Publications
Dillon M. B. C., Bachovchin, D. A., Brown S. J., Finn M.G., Rosen H., Cravatt III B.F., and Mowen K.A. (in press, ACS Chemical Biology) High-Throughput Screening for Novel PRMT1 Inhibitors by Activity-Based Fluorescent Polarization.
Hemmers S., Teijaro J., Arandjelovic S., and Mowen K.A. (Jul 2011). Regulation of Influenza Infection by Neutrophil-expressed Peptidylarginine Deiminase 4. PlosOne 6(7):e22043.
Weerapana E., Wang C., Simon G.M., Khare S., Richter F., Dillon M.B.D., Bachovchin D.A., Mowen K.A., Baker D., and Cravatt B.F. (2010) Quantitative reactivity profiling predicts functional cysteines in native and designed proteins. Nature 468 (7325):790-5.
Arandjelovic S., Leming S., Wickramarachchi D., Kono D. H., and Mowen K. A. (2010). Coronin-1 is not required for mast degranulation. J of Leukocyte Biology 88(4):737-45.
Fathman J.W., Gurish M.F., Hemmers S., Bonham K., Friend D.S., Grusby M.J., Glimcher L.H, and Mowen K. A. (2010). NIP45 Controls the Magnitude of the Type 2 T Helper Cell Response. Proc Natl Acad Sci. 107(8):3663-3668.
Bonham K., Lim Y-H., Hill D.H., Finn M.G., and Mowen K.A. (2010). Effects of a Novel Arginine Methyltransferase Inhibitor on T Helper Cell Cytokine Production. Febs Journal. 277(9):2096-108.
Hemmers S. and Mowen K.A. (2009). T(H)2 bias: Mina tips the balance. commentary. Nat Immunol 10:806-809.
Mowen K.A. and Glimcher L. H. (2004) Signaling Pathways in Th2 Development. Immunological Reviews. 202:203.
Mowen K.A., Schurter B.T., Fathman J., David M, and Glimcher L. H. (2004) . Arginine Methylation of NIP45 Modulates Cytokine Gene Expression in Effector T Lymphocytes. Molecular Cell. 15:559.
Rengarajan J., Mowen K., McBride K. D., Smith E. D., Singh H., and Glimcher L. H. (2002). Interferon regulatory factor (IRF4) interacts with NFATc2 to modulate IL-4 gene expression. J Exp Med. 195:1003-1012.
Mowen, KA and David M. (2001). Analysis of protein arginine methylation and protein arginine methyltransferase activity. Sci STKE. Jul 31;2001 (93).
Blesofsky, WA, Mowen K., Arduini RM, Baker DP, Murphy MA, Bowtell DD, David M. (2001). Regulation of STAT protein synthesis by c-Cbl. Oncogene. 20:7326-7333.
Mowen KA, and David, M. (2001). Cytokine activation of transcription. Genet Engineering, Principles and Methods. Ed. J. K. Setlow, Kluwer Academic/Plenum Press.
Lieberson R., Mowen KA, McBride, KD, Leautaud, V, Zhang X, Suh WK, Wu L, and Glimcher, LH. (2001). Tumor necrosis factor receptor-associated (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45). J Exp Med. 194:89-98.
Mowen K., Tang J., Zhu W., Schurter B T, Shuai K, Herschman H., and David M. (2001) Arginine Methylation of STAT1 modulates IFNa/b induced Transcription. Cell. 104:731-741.
Mowen K., and David, M. (2000). Regulation of STAT1 Nuclear Export by Jak1. Mol Cell Biol. 20:7273-7281.
Mowen K. and David M. (1998). Role of the STAT1-SH2 Domain and STAT2 in the Activation and Nuclear Translocation of STAT1. JBC. 273:30073-30076.
Navarro L., Mowen K., Rodems S., Weaver B., Reich, N., Spector S., and David M. (1998). Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3 – Containing Interferon Stimulated Response Element-Binding Complex. MCB 18: 3796-3802.
Huggenvik, J., Michelson, R. J., Collard M.W., Ziemba A. J., Gurley P., and Mowen K. A. (1998). Characterization of a Nuclear Deformed Epidermal Autoregulatory Factor-1 (DEAF-1) Related (NUDR) Transcriptional Regulator Protein. Mol. Endo. 12: 1619-1639.
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