Bruce Torbett

Departments of Molecular and Experimental Medicine and Immunology The Scripps Research Institute

Head, Molecular and Cellular Therapy, The Scripps Cancer Center

Adjunct Associate Professor, Graduate Program in Molecular Pathology, Department of Pathology, School of Medicine, UCSD


10550 North Torrey Pines Road, MEM-131
La Jolla, CA 92037
Phone: (858) 784-9123
FAX: (858) 784-7714

betorbet@scripps.edu

 

 

Quick Search

1980- 1985- 1990- 1995- 2000- 2005

 

1980-1984

1. Torbett, B.E., Carey, A.B. and Marquardt, W.C. A new species of Eimeria from the Golden-Mantled ground squirrel, Spermophilus lateralis, in Northern Colorado. J. Proto. Zool. 29:157, 1982.

top- 1980- 1985

1985-1989

2. Torbett, B.E., Skidmore, B. and Clark, W.R. Multiple pathways for antigen-independent activation of a T-helper hybridoma. Eur. J. Immunol. 16:933, 1986.

3. Torbett, B.E. and Clark, W.R. The role of accessory molecules in T-helper activation induced by antigen, lectin, or CD3 antibodies. Cell. Immunol. 115:352, 1988.

4. Clark, W.R., Ostergaard, H., Gorman, K.C. and Torbett, B.E. Molecular mechanisms of CTL-mediated lysis: A cellular perspective. Immunol. Rev. 103:37, 1988.

5. Gorman, K.C., Blakely, A., Liu, C.-C., Young, J.D., Torbett, B.E. and Clark, W.R. Cloned cytotoxic T lymphocytes as target cells. Polarity of lysis revisited. J. Immunol. 141:2211, 1988.

6. Saxton, R.E., Burke, M.W., Torbett, B.E., Fairhurst, M., Morton, D.L. and Cochran, A.J. Detection of malignant melanoma with monoclonal antibodies. Disease Markers. 6:97, 1988.

7. Firestein, G.S., Roeder, W.D., Laxer, J.A., Townsend, K.S., Weaver, C.T., Horn, J.T. Linton, H.J., Torbett, B.E. and Glasebrook, A.L. A new murine CD4 T cell subset with an unrestricted cytokine profile. J. Immunol. 143:518, 1989.

top- 1980- 1985- 1990-

1990-1994

8. Torbett, B.E. and Glasebrook, A.L. Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 populations. Immunol. Letters 23:227, 1990.

9. Ernst, D.N., Hobbs, M.V., Torbett, B.E., Glasebrook, A.L., Rehse, M.A., Bottomly, K., Hayakawa, K., Hardy, R.R. and Weigle, W.O. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4 T cells from young and aged mice. J. Immunol. 145:295, 1990.

10. Hobbs, M.V., Ernst, D.N., Torbett, B.E., Glasebrook, A.L., Rehse, M.A., McQuitty, D.M., Thoman, M.A., Bottomly, K., Rothermel, A.L., Noonan, D. and Weigle, W.O. Cell proliferation and cytokine production by CD4 cells from old mice. J. Cell. Biochem. 46:312, 1991.

11. Mosier, D.E., Gulizia, R.J., Torbett, B.E., Baird, S.M. and Wilson, D. Break For SCIDs. Nature. 353:509, 1991.

12. Torbett, B.E., Picchio, G. and Mosier, D.E. hu-PBL-SCID mice: A model for human immune function, AIDS and lymphomagenesis. Immunol. Rev. Vol. 124:139, 1992.

13. Wineman, J.P., Gilmore, G. Gritzmacher, C., Torbett, B.E. and Muller-Siegberg, C.E. CD4 is expressed on murine pluripotent stem cells. Blood 80:1717, 1992.

14. Mosier, D.E., Picchio, G., Kirven, M.B., Garnier, J.L., Torbett, B.E., Baird, S.M. Kobayashi, R. and Kipps, T.J. EBV-induced human B cell lymphomas in hu-PBL-SCID mice. AIDS Res. and Human Retrovirus 8:735, 1992.

15. Mosier, D.E., Stell, K.L., Gulizia, R.J., Torbett, B.E. and Gilmore, G. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J. Exp. Med. 177:191, 1993.

16. Gahring, L.C., Ernst, D.N., Romball, C.G., Hobbs, M., Torbett, B.E. and Wiegle,W.O. The expression of CD45RB on CD4 lymphocytes: Mouse strain polymorphism and different responses to distinct antigens. Cell. Immunol. 148:269, 1993.

17. Mosier, D.E., Gulizia, R.J., MacIsaac, P.D. and Torbett, B.E. HIV-1 strain-dependent CD4 T cell depletion in hu-PBL-SCID mice. Prog. in Immunol. 725, 1993.

18. Mosier, D.E., Gulizia, R.J., MacIsaac, P.D., Torbett, B.E. and Levy, J.A. HIV-1 rapid CD4 T cell depletion in human-PBL-SCID mice by non-cytopathic macrophage-tropic isolates of HIV. Science 260:689, 1993.

19. Hobbs, M.V., Weigle, W.O., Noonan, D.J., Torbett, B.E., McEvilly, R.J., Koch, R.J., Cardenas, G.J. and Ernst, D.N. Cytokine gene expression by CD4 T cells from young and old mice. J. Immunol. 150:3602, 1993.

20. Reinhardt, B., Torbett, B.E., Gulizia, R.J, Reinhardt, P.P., Spector, S.A. and Mosier, D.E. Human immunodeficiency virus type 1 infection of neonatal severe combined immunodeficient mice xenografted with human cord blood cells. AIDS Res and Human Retrovirus 10:131, 1994.

21. Van Kyuk, R., Torbett, B.E., Gulizia, R.J., Leath, S., Mosier, D.E. and Koenig, S. Cloned human CD8+ cytotoxic T lymphocytes protect human-PBL-SCID mice against HIV-1 infection by an HLA-unrestricted mechanism. J. Immunol. 153:4826, 1994.

22. Ucker, D.S., Hebshi, L.D., Blomquist, J.F. and Torbett, B.E. Physiological T cell death: Susceptibility is modulated by activation, aging, and transformation, but the mechanism is constant. Immunol. Rev. 142:273, 1994.

23. Torbett, B.E. and Mosier, D.E. Does preferential Th subset activation contribute to the murine acquired immunodeficiency disease MAIDS? Forum Immunol., 145:696, 1994.

top- 1980- 1985- 1990- 1994-

1995-1999

24. McKercher, S., Torbett, B.E., Anderson, K.L., Henkel, G., Vestal, D.J., Klemsz, M., Feeney, A.J., Wu, G.E., Paige, C.J. and Maki, R.A. Targeted disruption of the PU.1 gene results in hematopoietic abnormalities. EMBO. J., 15:5647, 1996.

25. Anderson, K.L., Smith, K.A., Conners, K., McKercher, S., Maki, R.A. and Torbett, B.E. Myeloid development is selectively disrupted in PU.1 null mice. Blood, 91:3702, 1998.

26. Lee, T., Laco, G.S., Torbett, B.E., Fox, H.S., Lerner, D.L., Elder, J.H. and Wong, C-H. Analysis of the S3 and S3’ subsite Specificities of the FIV Protease; Development of a broad-0-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo. P.N.A.S. 95:939, 1998.

27. Anderson, K.L, Smith, K. A., Pio, F., Torbett, B.E. and Maki, R.A. PU.1 null neutrophils are functionally deficient and fail to terminally differentiate. Blood, 92:1576, 1998.

28. Pedroza-Martins, L., Gurney, K., Torbett, B.E. and Uittenbogaart, C.H. Differential tropism and replication kinetics of HIV-1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the post-entry level. J. Virol. 12:9441, 1998.

29. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M. and Torbett, B.E. HIV vectors efficiently transduce human CD34+ cells that mediate long-term engraftment of NOD/SCID mice. Science, 283:682, 1999.

30. Anderson, K.L., Smith, K.A., Perkin, H., Anderson, C.-G., Hermanson, G., Jolly, D.J., Maki, R.A. and Torbett, B.E. PU.1 and the M-CSF and G-CSF receptors play distinct roles in late-stage myeloid differentiation. Blood, 94: 1999.

31. Kim, Y.-M., Kang, H.-S., Paik, S.-Gi., Pyun, K.-H., Anderson, K.L., Torbett, B.E. and Choi, I. Roles of ICSBP and PU.1 in regulating IL-18 gene expression. J. Immunol., 163:200, 1999.

32. Crisa, L.C., Cirulli, V., Smith, K.A., Ellisman, M., Torbett, B.E. and Salomon, D.R. Human cord blood progenitors sustain thymic T-cell development and a novel form of angiogenesis. Blood, 943:298, 1999.

top- 1980- 1985- 1990- 1995-1999

2000-2004

33. Anderson, K.L., Perkin, H., Smith, K.A., Surh, C.D., Venturini, S., Maki, R.A. and Torbett, B.E. PU.1 regulates development of thymic and hematopoietic progenitor derived (myeloid) dendritic cell populations. J. Immunol., 164:1855, 2000.

34. Steinberger, P., Widhopf-Andris, J., Bühler, B., Torbett, B.E. and Barbas, III, C.F. Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion. P.N.A.S., 97:805, 2000.

35. Mayrand, S.M., Healy, P.A., Torbett, B.E. and Green, W.R. Genetic resistance to the MAIDS virus, LP-BM5, maps to H-2d. Virology, 272:438, 2000.

36. Pelletier, A.J., van der Laan, L., Siani, M.A., Thompson, D.A., Torbett, B.E. and Salomon, D.R. Presentation of Chemokine SDF-1a by fibronectin mediates directed migration of T cells. Blood, 96;2683, 2000.

37. van der Laan, J.W., Lockey, C., Griffeth, B.C., Frasier, F.S., Wilson, C.A., Onions, D.E., Hering, B.J., Long, Z., Otto, E., Torbett, B.E. and Salomon, D.R. Infection by porcine endogenous retrovirus after islet xenotransplantation. Nature, 407:90, 2000.

38. Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K.A., Mueller, B., Narravula, S., Torbett, B.E., Orkin, S.H. and Tenen, D.G. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood, 96:2682, 2000.

39. Anderson, K.L., Nelson, S., Perkin, H., Smith, K.A., Klemsz, M.J. and Torbett, B.E. PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45. J. Biol. Chem., 276:7637, 2001.

40. Bühler, B., Lin, Y-C., Morris, G., Olson, A., Wong, C.-H., Richman, D.D., Elder, J.H. and Torbett, B.E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3. J. Virol., 75:9502, 2001.

41. Manchester, M., Smith, K.A., Eto, D.S., Perkin, H. and Torbett, B.E. Targeting and hematopoietic suppression of human CD34+ cells by measles virus. J. Virol. 76:6636, 2002.

42. Torbett, B.E. Reporter Genes: Too much of a good thing? J. Gene Med. 4:478, 2002.

43. Beutler, E., West, C., Torbett, B.E. and Deguchi, H.A. Chimeric mouse model of Gaucher disease. Mol. Med., 8:247, 2002.

44. Gombat, A.F., Kwok, S.H., Anderson, K.L., Yamaguchi, Y., Torbett, B.E. and Koeffler, H.P. Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP and PU.1. Blood, 101:3265, 2003.

45. Tschan, M.P., Fischer, K.M., Fung, V.S, Pirnia, F., Borner, M.M., Fey, M. F. Tobler, A. and Torbett, B.E. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. J. Biol. Chem., 278:42750, 2003.

46. Kutilek, V.D., Sheeter, D.A., Elder, J.H. and Torbett, B.E. Is Resistance Futile? Current Drug Targets-Infectious Disorders, 3:295, 2003.

47. Criscuoli, M., Reddy, V., Torbett, B.E., and Eliceiri, B.P. Src kinase requirement for Erk1/2 activation in blood vessels during stroke. Endothelium, 10:341, 2003.

48. Huitron-Resendiz, S., de Rozieres, S., Sanchez-Alavez, M., Bühler, B., Lin, Y-C., Lerner, D.A., Henriksen, N.W., Burudi, M., H.S., Torbett, B.E., Henriksen, S. Elder, J.H. Resolution and prevention of FIV-induced neurological deficits by treatment with the protease inhibitor, TL-3. J, Virol., 78:4525, 2004.

49. Segal, D.J., Gonclaves, J., Eberhardy, S., Swan, C.H., Torbett, B.E., Barbas, C.F. 3rd. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J. Biol. Chem., 279:14509, 2004.

50. Hildbrand, P., Cirulli, V., Prinsen, R. C., Smith, K. A., Torbett, B. E., Salomon, D. R., Crisa, L. The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors. Blood, 104:2010, 2004.

51. de Rozieres, S., Swan, C. H., Sheeter, D.A., Clingerman, K.J., Lin-Y.-C., Huitron-Resendiz, S., Henriksen, S., Torbett, B.E. and Elder, J.H. Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3. Retrovirology 1:38, 2004.

top- 1980- 1985- 1990- 1995-1999-2005

2005-2008

52. Britschgi, C., Rizzi, M., Grob, T.J., Tschan, M.P., Hugli, B., Reddy, V.A., Andres, A-C., Torbett, B.E., Tobler, A., and Fey, M.F. Identification of the p53 family-responsive element in the promoter region of the tumor osuppressor gene hypermethylataed in cancer 1. Oncogene 25: 2030, 2006.

53. Heaslet, H., Kutilek, V.D., Morris, G., Elder, J.H., Lin, Y-C., Torbett, B.E., and Stout, D.C. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3. J. Mol. Biol., 356:967, 2006.

54. Swan, C.H. and Torbett, B.E. Can gene delivery close the door to HIV-1 entry after escape? J. Med. Primatology 35:236, 2006.

55. Swan, C.H., Buhler, B., Tschan, M.P., Barbas, C.F. III, and Torbett, B.E. T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery. Gene Therapy, 13: 1480, 2006.

56. Cirulli, V., Zalatan, J., McMaster, M., Prinsen, R., Salomon, D.R., Ricordi, C., Meda, P., Torbett, B.E. and Crisa, L. The class I HLA repertoire of pancreatic islets comprises the non-classical class 1b antigen HLA-G. Diabetes 55: 1214-22, 2006.

57. Lin, Y-C., Brik, A., Parseval, A., Tam, K., Torbett, B.E., Wong, C.H., and Elder, J.H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. J. Virol. 80:7832, 2006.

58. Manuel, E.R., Charini, W.A., Sen, P., Peyerl, F.W., Kuroda, M.J., Schmitz, J.E., Autissier, P., Sheeter, D.A., Torbett, B.E., Letvin, N.L. Contribution of TCR Repertoire Breadth to the Dominance of Epitopoe-Specific CD8+ T Lymphocyte Responses. J. Virol. 80:12032, 2006.

59. Heaslet, H., Lin, Y.-C., Tam, K., Torbett, B.E., Elder, J.H., and Stout, C.D. Crystal structure of an FIV/HIV chimeric protease complexled with the broad-based inhibitor, TL-3. Retrovirology 4:1, 2007.

60. Rizzi, M., Tschan, M.P., Britschgi, C., Britschgi, A., Grob, T.J., Hugli, B., Leupin, N., Torbett, B.E., Ziemiecki, A., Fey, M.F., and Tobler, A. The death-associated protein kinase 2 (DAPK2) is upregulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. J. Leukocyte Biol. 81:1599, 2007.

61. Heaslet, H., Rosenfeld, R., Giffin, M., Lin, Y.C., Tam, K., Torbett, B.E., Elder, J.H., McRee, D.E., Stout, C.D. Conformation flexibility in the flap domains of ligand-free HIV protease. Acta. Crystallogr. D. Biol. Crystallogr. 63:866, 2007.

62. Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B.E., Tenen, D.G., Friedman, A.D. C/EBPa binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood 110:3136, 2007.

63. Tschan, M.P., Gullberg, U., Shan, D., Torbett, B.E., Fey, M.F., Tobler, A. The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Leukemia 22: 1087, 2007.

64. Tschan, M.P., Britschgi, C., Moser, B.A., Reddy, V.A., Sheeter, D.A., Fischer, K.M., Sun, P. and Torbett, B.E. Human DMP1beta is a Negative Regulator of the p14ARF Tumor Suppressor and Promotes Cellular Proliferation. Accepted, J. Biol. Chem., 2008.

65. Tschan, M.P., Reddy, V.A., Torbett, B.E. PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity. Oncogene 27:3489, 2008.

66. Blancafort, P., Tschan, M.P., Bergquist, S., Guthy, D., Brachat, A., Sheeter, D.A., Torbett, B.E., Edrman, D., Barbas, C.F. III. Modulation of drug resistance by artificial transcription factors. Mol. Cancer Ther. 7:688, 2008.

67. Britschgi, C., Jenal, M., Arvidsson, G., Rizzi, M., Torbett, B.E., Mueller, B.U., Andres, A.-C., Tobler, A., Fey, M.F., Tschan, M.P. HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation. Brit. J. of Haem. 141: 179, 2008.

68. Miller, R., Cirulli, V., Diaferia, G.R., Ninniri, S., Hardiman, G., Torbett, B.E., Benezra, R., and Crisa, L. Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes 57:2402, 2008.

69. Fang, J., Menon, M., Zhang, D., Torbett, B., Oxburgh, L., Tschan, M., Houde, E., and Wojchowski, D.M. Attenuation of EPO-dependent erythroblast formation by death associated protein kinase 2. Blood 112:886, 2008.

70. Thrash, J.C., Torbett, B.E., Carson, M.J. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: Implications for Nasu-Hakola Disease. Accepted, Neurochem. Res., 2008.

71. Giffin, MJ., Heaslet, H., Cauvi, G., Brik, A., Lin, Y-C., Stout, C.D., Wong, C-H., Elder, J.H., and Torbett, B.E. AB2, an azide-alkyne click compound, is a potent inhibitor of a multidrug-resistant mutant protease arising from protease inhibitor selection. J. Med. Chem. 51:6263, 2008.


 

 
 

 

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