Daniel Salomon, M.D.

BIOSKETCH:

Dr. Salomon is an Associate Professor at The Scripps Research Institute (TSRI) in the Department of Molecular and Experimental Medicine. He is also a faculty member of the TSRI Graduate Program. He is the Co-Director of the Center for Organ and Cell Transplantation for Scripps Health at Scripps Green Hospital . He also serves as the Director of the Core Laboratory for TSRI's General Clinical Research Center and Co-Director of the GCRC DNA Microarray Core.

His undergraduate training was at Northwestern University (Chemistry) and graduate training at the Stritch-Loyola School of Medicine (Medicine, 1976). He did his internship, residency and was Chief Medical Resident at Cedars-Sinai Medical Center , University of California , Los Angeles (1976 to 1980). Nephrology and Transplantation Immunology fellowships were done at the Brigham and Women's Hospital, Harvard Medical School (1980 to 1984). In 1984 he became the Medical Director of the Kidney Transplant Program at the University of Florida and developed and directed the Heart Transplant Program from 1985 to 1990. In 1990, he moved to the Laboratory of Immunology at the NIH to concentrate on basic laboratory work in molecular immunology and transplantation. These studies have continued since 1993 at TSRI.

Dr. Salomon's laboratory work is focused on various aspects of cell transplantation, xenotransplantation, tissue engineering, therapeutic gene delivery and functional genomics. This work includes studies on the risk and virology of Porcine Endogenous Retrovirus (PERV), the use of lentiviral gene therapy to deliver proangiogenic and immunosuppressive therapeutics for tissue engineering, strategies to encapsulate pig islets for xenotransplantation and studies of the molecular signals involved in the maturation of endothelial progenitor cells during angiogenesis. A major effort is now underway to use the developing technologies of DNA gene chips, proteomics and complex trait genetics to diagnose acute and chronic rejection and guide the use of immunosuppressive drugs in kidney and liver transplant patients.

Presently, Dr. Salomon is the Chair of the Scientific Advisory Board of MicroIslet and has a collaborative research program with MicroIslet scientists. This research is to determine the potential of encapsulating pig islets for xenotransplantation and human islets for allotransplantation in patients with diabetes mellitus.

Dr. Salomon is a Special Government Employee of the U.S. FDA and chaired the Biological Response Modifiers Advisory Committee (BRMAC) from 1999-2003. He was a member of the U.S. Secretary of Health's Xenotransplantation Advisory Committee from its inception until 2003. Dr. Salomon is presently the Chair of the Steering Committee of the NIH National Islet Cell Resource Consortium, Chair of the American Society of Transplantation Cell Transplantation Committee, Chair of the American Society of Gene Therapy's Regulation and Clinical Trials Committee and a member of the NIH Transplantation, Tolerance and Tumor Immunology Study Section.



BIOSKETCH: Dr. Salomon is an Associate Professor at The Scripps Research Institute (TSRI) in the Department of Molecular and Experimental Medicine. He is also a faculty member of the TSRI Graduate Program. He is the Co-Director of the Center for Organ and Cell Transplantation for Scripps Health at Scripps Green Hospital . He also serves as the Director of the Core Laboratory for TSRI's General Clinical Research Center and Co-Director of the GCRC DNA Microarray Core. His undergraduate training was at Northwestern University (Chemistry) and graduate training at the Stritch-Loyola School of Medicine (Medicine, 1976). He did his internship, residency and was Chief Medical Resident at Cedars-Sinai Medical Center , University of California , Los Angeles (1976 to 1980). Nephrology and Transplantation Immunology fellowships were done at the Brigham and Women's Hospital, Harvard Medical School (1980 to 1984). In 1984 he became the Medical Director of the Kidney Transplant Program at the University of Florida and developed and directed the Heart Transplant Program from 1985 to 1990. In 1990, he moved to the Laboratory of Immunology at the NIH to concentrate on basic laboratory work in molecular immunology and transplantation. These studies have continued since 1993 at TSRI. Dr. Salomon's laboratory work is focused on various aspects of cell transplantation, xenotransplantation, tissue engineering, therapeutic gene delivery and functional genomics. This work includes studies on the risk and virology of Porcine Endogenous Retrovirus (PERV), the use of lentiviral gene therapy to deliver proangiogenic and immunosuppressive therapeutics for tissue engineering, strategies to encapsulate pig islets for xenotransplantation and studies of the molecular signals involved in the maturation of endothelial progenitor cells during angiogenesis. A major effort is now underway to use the developing technologies of DNA gene chips, proteomics and complex trait genetics to diagnose acute and chronic rejection and guide the use of immunosuppressive drugs in kidney and liver transplant patients. Presently, Dr. Salomon is the Chair of the Scientific Advisory Board of MicroIslet and has a collaborative research program with MicroIslet scientists. This research is to determine the potential of encapsulating pig islets for xenotransplantation and human islets for allotransplantation in patients with diabetes mellitus. Dr. Salomon is a Special Government Employee of the U.S. FDA and chaired the Biological Response Modifiers Advisory Committee (BRMAC) from 1999-2003. He was a member of the U.S. Secretary of Health's Xenotransplantation Advisory Committee from its inception until 2003. Dr. Salomon is presently the Chair of the Steering Committee of the NIH National Islet Cell Resource Consortium, Chair of the American Society of Transplantation Cell Transplantation Committee, Chair of the American Society of Gene Therapy's Regulation and Clinical Trials Committee and a member of the NIH Transplantation, Tolerance and Tumor Immunology Study Section.