PUBLICATIONS
Wang N.S., McHeyzer-Williams L.J., Okitsu S.L., Burris T.P., Reiner S.L., McHeyzer-Williams M.G. (2012) Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha. Nat Immunol 6: 604-11.PubMed Abstract
McHeyzer-Williams, M.G., Okitsu, S.L., Wang, N.S., McHeyzer-Williams, L..J. (2011) Molecular programming of B cell memory. Nat Rev Immunol. 12(1): 24-34. Review. PubMed Abstract
Pelletier, N., McHeyzer-Williams, L.J., Wong, K.A., Urich E., Fazilleau, N., McHeyzer-Williams, M.G. (2010) Plasma cells negatively regulate the follicular helper T cell program. Nature Immunology 11(12): 1110-8. PubMed Abstract
Ait-Azzouzene, D., Kono, D.H., Gonzalez-Quintial, R., McHeyzer-Williams, L.J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A.L., Skog, P., McHeyzer-Williams, M.G., Nemazee, D., Theofilopoulos, A.N. (2010) Deletion of IgG-switched autoreactive B cells and defects in Fas(Ipr) lupus mice. J. Immunol. 185(2):1015-27. PubMed Abstract
Milner, J.D., Fazilleau, N., McHeyzer-Williams, M.G. (2010) Cutting edge: lack of high affinity competition for peptide in poyclonal CD4+ responses unmasks IL-4 production. J. Immunol. 184(12):656-73. PubMed Abstract
Pelletier, N., McHeyzer-Williams, M.G. (2009) B cell memory: how to start and when to end. Nature Immunology 10(12):1233-5. PubMed
Todd, D.J., McHeyzer-Williams, L.J., Kowal, C., Lee A.H., Volpe B.T., Diamond, B., McHeyzer-Williams, M.G., Glimcher, L.H. (2009) XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J. Exp. Med. 206(10): 2151-9. PubMed Abstract
McHeyzer-Williams, M.G., Nussenzweig, M.C. (2009) Introduction to the section on lymphocyte activation and effector function. Curr. Opin. Immunol. 21(3): 241-3. PubMed
McHeyzer-Williams, L.J., Pelletier, N., Mark, L., Fazilleau, N., McHeyzer-Williams, M.G. (2009) Follicular helper T cells as cognate regulators of B cell immunity. Curr. Opin. Immunol. 21(3):266-73. Review. PubMed Abstract
Fazilleau, N., Mark, L., McHeyzer-Williams, L.J., McHeyzer-Williams, M.G. (2009) Follicular helper T cells: lineage and location. Immunity 30(3): 324-35. Review. PubMed Abstract
Fazilleau, N., McHeyzer-Williams, L.J., Rosen, H., McHeyzer-Williams, M.G. (2009) The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nature Immunology 10(4): 375-84. PubMed Abstract
Malherbe, L.P., Mark, L., Fazilleau, N.R., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2008) Vaccine adjuvants alter TCR-based selection thresholds. Immunity 28(5):698-709. PubMed Abstract
McHeyzer-Williams, M.G. B lymphocyte biology. (2008) Fundamental Immunology 6th Edition. Edited by William Paul for Lippincott Press. 289-311.
Fazilleau, N.R., Eisenbraun, M.D., Malherbe, L.P., Ebright, J.N., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2007) Lymphoid reservoirs of antigen-specific memory T helper cells. Nature Immunology 8:753-761. PubMed Abstract
Fazilleau, N.R., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2007) Local development of effector and memory T helper cells. Curr. Opin. Immunol. 19 (3) 259-267. Review. PubMed Abstract
McHeyzer-Williams, M.G. (2007) Local sentries for class switching. Nature Immunology 8: 230-2. PubMed
McHeyzer-Williams, L.J. and McHeyzer-Williams M.G. (2007) Memory B cell evolution: B cell biology. Adv Exp Med Bio. 596:31-45. Review. PubMed
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2006) Memory B cell development .The Autoimmune Diseases Eds. Noel Rose and Ian Mackay Fourth Edition 157-166.
McHeyzer-Williams, L.J., Malherbe, L.P. and McHeyzer-Williams, M.G. (2006) Helper T cell-regulated B Cell Immunity. Curr. Topics in Micro. and Immunol. 311: 83-107. Review.
PubMed Abstract
McHeyzer-Williams L.J., Malherbe L.P., McHeyzer-Williams M.G. (2006) Checkpoints in memory B-cell evolution. Immunol Rev. Jun;211:255-68. Review. PubMed Abstract
McHeyzer-Williams, M.G., McHeyzer-Williams, L.J., and Malherbe, L. (2006) B cells discriminate the rules of engagement. Immunity 24(2):125-7. PubMed Abstract
Alfonso, C., McHeyzer-Williams, M.G. and Rosen, H. (2006) CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors. Eur. J. Immunol. 36(1): 149-159. PubMed Abstract
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. Antigen-specific memory B cell development. (2005) Annual Reviews Immunol. Vol. 23:487-513. Review. PubMed Abstract
Malherbe L, Hausl C, Teyton L, McHeyzer-Williams MG. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. (2004) Immunity 21(5):669-79. PubMed Abstract
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. Developmentally-distinct Th cells control plasma cell production in vivo. (2004) Immunity 20:231-242. PubMed Abstract
McHeyzer-Williams L.J. and McHeyzer-Williams, M.G. (2004) Analysis of antigen-specific B-cell memory directly ex vivo. Methods Mol Biol. 271:173-88. PubMed Abstract
Rosen H., Alfonso, C., Surh, C.D. and McHeyzer-Williams, M.G. Rapid Induction of medullary thymocyte phenotypic maturation and inhibition of thymic egress at low nanomolar concentrations of S1P receptor agonist. (2003) Proc Natl. Acad. Sci USA 100: 10907-10912. PubMed Abstract
Shapiro-Shelef, M.A., Lin, K-I., McHeyzer-Williams, L.J., Liao, J., McHeyzer-Williams, M.G. and Calame, K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. (2003) Immunity 19:607-620. PubMed Abstract
McHeyzer-Williams, M.G., McHeyzer-Williams, L.J., Driver D.J., Panus, J.F., Bikan, G., Pogue-Caley, R.R. and Eisenbraun, M.D. (2003) Helper T cell-regulated B cell immunity. Microbes and Infection 5: 205-212. PubMed Abstract
McHeyzer-Williams, M.G. (2003) B cell as Effectors. Curr. Opin. Immunol. 15:354-361 PubMed Abstract
McHeyzer-Williams, M.G. (2003). B cell signaling and activation. In: Fundamental Immunology, 5th edition. W.E. Paul (Ed.) Lippincott Williams & Wilkins, Baltimore, MD. Chapter 7, 195-226
McHeyzer-Williams, L.J., Malherbe, L.P., Eisenbraun, M.D., Driver D.J. and McHeyzer-Williams, M.G. (2002). Development of antigen-specific helper T cell responses in vivo. Adv in Exp. Med and Biol., 512:11-20
Borron,P., Mostaghel E., Doyle, C., Walsh E., McHeyzer-Williams, M. and Wright J.R. (2002). Pulmonary surfactant proteins-A and –D directly suppress CD3+/CD4+ cell function. J. Immunol 15:5844-50. PubMed Abstract
Driver, D.J., McHeyzer-Williams, L.J., Cool, M., Stetson, D.B. & McHeyzer-Williams, M.G. (2001) Development and maintenance of a B220- memory B cell compartment. J. Immunol. 167(3): 1393-405. PubMed Abstract
McHeyzer-Williams, M.G., McHeyzer-Williams, L.J., Fanelli Panus, J., Bikah, G., Pogue-Caley, R.R., Driver, D.J., and Eisenbraun M.D. (2001) Antigen-specific immunity. Th cell-dependent B cell responses. Immunol. Res. 22(2-3): 223-36. PubMed Abstract
Pogue-Caley, R.R. and McHeyzer-Williams, M.G. (2001) Emergence of a cII-specific Th cell response. Eur. J. Immunol. 31(8): 2362-72.
PubMed Abstract
McHeyzer-Williams, L.J., Driver, D.J. and McHeyzer-Williams, M.G. (2000) The germinal center reaction. Curr. Opin. Hematol. 8:52-59. PubMed Abstract
Bikah, G.*, Pogue-Caley, R.R.*, McHeyzer-Williams, L.J. & McHeyzer-Williams, M.G. (2000) Regulating T helper cell immunity through antigen responsiveness and calcium entry. Nature Immunology 1(5):402-412. PubMed Abstract
McHeyzer-Williams, L.J., Cool, M., McHeyzer-Williams, M.G. (2000). Antigen-specific B cell memory: expression and replenishment of a novel B220- memory B cell compartment. J. Exp. Med. 191:1149-1165.
PubMed Abstract
Panus, J.F., McHeyzer-Williams, L.J. & McHeyzer-Williams, M.G. (2000) Antigen-specific T helper cell function: differential cytokine expression in primary and memory responses. J. Exp. Med. 6:1301-1316. PubMed Abstract
Lu, F.W.M., Yasutomo, K., Goodman, G.B., McHeyzer-Williams, L.J., McHeyzer-Williams, M.G., Germain, R.N., Ashwell, J.D. (2000). Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire. Immunity 12: 183-192 PubMed Abstract
Mikszta, J.A., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (1999). Antigen-driven selection of T cell receptors in vivo: related TCRa chains pair with diverse TCRb chains. J. Immunol. 163:5978-5988. PubMed Abstract
Ansel, K.M., McHeyzer-Williams, L.J., McHeyzer-Williams, M.G., Cyster, J.G. (1999) In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190 (8):1123-1134. PubMed Abstract
McHeyzer-Williams, L.J., Fanelli Panus, J., Mikszta, J.A., McHeyzer-Williams, M.G. (1999) Evolution of antigen-specific T cell receptors in vivo: Pre-immune and antigen-driven selection of preferred CDR3 motifs. J. Exp. Med. 189 (11):1823-1837. PubMed Abstract
Tedder, T.F., Zhuang, Y. and McHeyzer-Williams, M.G. (1999) The humoral immune response. In: Anderson, K.A. Ness, P.M. Eds. Scientific Basis of Transfusion Medicine: Implications for Clinical Practice. 2nd edition. WB Saunders Co., Philadelphia.
McHeyzer-Williams, M.G. and Ahmed, R. (1999). B cell memory and the long-lived plasma cell. Curr. Opin. Immunol. 11:172-179. PubMed Abstract
McHeyzer-Williams, M.G. and Davis, M.M. (1997) Isolation and molecular characterization of single antigen-specific TH cells. In: The Handbook of Experimental Immunology, 5th edition. L.A. Herzenberg, L.A. Herzenberg and D.M. Weir (Eds.) Blackwell Science, Cambridge.
McHeyzer-Williams, M.G. (1997) Antigen-specific B lymphocyte differentiation in vivo. Seminars in Immunology 9: 219-227. PubMed Abstract
Davis, M.M., Lyons, D.S., Altman, J.D., McHeyzer-Williams, M.G., Hampl, J., Boniface, J.J. and Chien, Y. (1997) T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure. Ciba Found Symp. 204:94-100. PubMed Abstract
McHeyzer-Williams, M.G. (1996) Visualizing immune responses in vivo. Curr. Opin. Immunol. 8:321-326. PubMed Abstract
Altman, J.D., Moss, P.A.H., Goulder, P.J.R., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J., Davis, M.M. (1996) Phenotypic analysis of antigen-specific T Lymphocytes. Science. 274:94-96.
PubMed Abstract
McHeyzer-Williams, M.G. Altman, J.D., and Davis, M.M. (1996) Tracking the T cell immune response in vivo. Curr. Opin. Immunol. 8: 278-284. PubMed Abstract
McHeyzer-Williams, M.G., Altman, J.D., and Davis, M.M (1996) Enumeration and characterization of memory cells in the TH compartment. Immunol. Rev. 50: 1-21
PubMed Abstract
Davis, M.M., McHeyzer-Williams,M.G. and Chien, Y. (1995) T-cell receptor V-region usage and antigen specificity: The cytochrome C model system. In: T-cell Receptor Use in Human Autoimmune Disease, J. Buxbaum and M. Davis (Eds.), Ann. of N.Y. Acad. Sci. 756:1-11. PubMed Abstract
McHeyzer-Williams, M.G. & Davis M.M. (1995) Antigen-specific helper T-cell development in vivo. Science. 268:106. PubMed Abstract
Ford, J.E., McHeyzer-Williams, M.G., and Lieber, M.L. (1995) Mechanistic properties of somatic hypermutation. Ann. of N.Y. Acad. Sci. 764:187-8 PubMed Abstract
Ford, J.E., McHeyzer-Williams, M.G., and Lieber, M.L. (1994) PCR recombination interferes with analysis of somatic mutation. Gene. 142: 279.PubMed Abstract
Ford, J.E., McHeyzer-Williams, M.G., andLieber, M.L. (1994) Analysis of individual immunoglobulin l light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation. Eur. J.Immunol. 24:181.
PubMed Abstract
McHeyzer-Williams, M.G., McLean, M.J., Lalor, P.A., Nossal, G.J.V. (1993)Antigen-driven B cell differentiation in vivo. J. Exp. Med. 178: 295. PubMed Abstract
Nossal, G.J.V., McHeyzer-Williams, M.G., Pulendran, B., McLean, M., Lalor P.A., and Karvelas, M. (1993) Immunological tolerance revisited in the molecular era (Ehrlich Lecture). In: Progress in Immunology VIII. J. Gergely, M. Benczur, A. Erdie, A. Falus, G. Fust, G. Medgyesi, G. Petranyi, E. Rajnavolgyi, (Eds.), Springer-Werlag, Berlin and Heidelberg, pp 3-9.
Troutt, A.B., McHeyzer-Williams, M.G., Pulendran, B. and Nossal, G.J.V. (1992) Ligation anchored PCR: A simple amplification technique with single-sided specificity. Proc. Natl. Acad. Sci. USA. 89: 9823 PubMed Abstract
Lalor, P.A., Nossal, G.J.V., Sanderson, R.D. and McHeyzer-Williams, M.G. (1992)Functional and molecular characterization of single NP-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to (4-hydroxy-3-nitrophenyl)acetyl (NP). Eur. J. Immunol. 22:3001. PubMed Abstract
McHeyzer-Williams, M.G., McLean, M.J., Nossal, G.J.V. and Lalor, P.A. (1992) The dynamics of T cell-dependent B cell responses in vivo. Immunol. and Cell Biol. 70:119. PubMed Abstract
McHeyzer-Williams, M.G., Nossal, G.J.V., Lalor, P.A. (1991) Molecular characterization of single memory B cells. Nature. 350:502. PubMed Abstract
McHeyzer-Williams, M.G. and Nossal, G.J.V. (1989) Inhibition of antibody-production at high cell density following mitogen stimulation and isotype switch in vitro. J. Immunol. Methods. 119:9. PubMed Abstract
McHeyzer-Williams, M.G. and Nossal G.J.V. (1988) Clonal analysis of autoantibody-producing cell precursors in the pre-immune B cell repertoire. J. Immunol. 141:4118. PubMed Abstract
PATENT
Altman, J.D., McHeyzer-Williams, M.G. and Davis, M.M. (1995) (File no: A-60471/BIR STAN-173). MHC-antigen complexes (tetramers) for detecting and purifying antigen-specific T cells.
